RESUMO
An investigation of immediate and long-term results of treatment of 2028 patients with cancer of the lung (in 1267 patients the surgical treatment was combined with the radiation component) has shown that the combined treatment is indicated to patients with the II-III stages of lung cancer.
Assuntos
Neoplasias Pulmonares/cirurgia , Pulmão/cirurgia , Pneumonectomia , Humanos , Pulmão/efeitos da radiação , Neoplasias Pulmonares/radioterapia , Cuidados Pós-Operatórios , Cuidados Pré-Operatórios , Doses de RadiaçãoRESUMO
Histological, histochemical and ultrastructural analysis of a rare benign tumour of peritoneum, called "cystic mesothelioma", is performed. Cystic mesothelioma is characterized histologically by a combination of cystic, papillary and adenomatoid structures; mesothelial cell signs are seen ultrastructurally.
Assuntos
Mesotelioma/patologia , Neoplasias Peritoneais/patologia , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
To assess the effect of the fungicide hexachlorobenzene (HCB) on lysosomal membrane stability in rabbits, the authors determined the activity of two lysosomal enzymes (beta-N-acetylglucosaminidase, CP 3.2.1.30 and alpha-mannosidase, CP 3.2.1.24) in the blood serum, and free unsedimentable activity of the former enzyme in liver homogenates. The activities of beta-N-acetylglucosaminidase and alpha-mannosidase were found to be enhanced on the 7th and 50th days after daily administration of HCB in doses 280 and 105 mumol/kg body mass, respectively. In chronic experiments, there was also an increase in free and unsedimentable activity of beta-N-acetylglucosaminidase in liver homogenates. Increased permeability of lysosomal membranes due to HCB indicates that lysosomes and acid hydrolases are implicated in the pathogenesis of intoxication under consideration.
Assuntos
Permeabilidade da Membrana Celular/efeitos dos fármacos , Clorobenzenos/intoxicação , Hexaclorobenzeno/intoxicação , Membranas Intracelulares/efeitos dos fármacos , Lisossomos/efeitos dos fármacos , Animais , Lisossomos/enzimologia , Masculino , Coelhos , Fatores de TempoRESUMO
Thirty patients suffering from chronic kidney disease were examined for urinary, fecal and total plasma porphyrins. Twenty patients had nitrogen retention whereas the remaining ten patients displayed normal values. Urinary coproporphyrin excretion and total plasma porphyrin levels were comparatively less pronounced in patients with nitrogen retention. Such changes in porphyrin metabolism could be explained by a diminished capacity for kidney excretion. It is concluded that the total amount of porphyrins synthesized in the body is decreased as a result of nitrogen retention.
