[Clinical and some biochemical features of rhinosinusitis of different etiology]. / Klinicheskie i nekotorye biokhimicheskie osobennosti rinosinusitov razlichnoi étiologii.

Identified pathogens, and studied the features of the clinical picture, the level of antioxidant activity, the number of TBA-active products, cytokines, chaperones proteins and antibodies against them in the serum of patients with fungal, viral, bacterial rhinosinusitis (RS) were studied. Most RS of viral nature are caused by rhinoviruses, in turn, the causative agent of bacterial RS, most often acts as a polyflora (S. epidermidis, S. aureus, Pseudomonas aeruginosa). In the group of fungal RS prevailed A. fumigatus. It is noted that a more severe clinical picture in patients bacterial RS; it was manifested by a prolonged course, more pronounced nasal congestion, smell impairment and frequent relapses of the disease. High levels of LPO and a decrease in serum antioxidant activity were established for all studied infectious RS with a maximum imbalance in the LPO-AOP system in fungal forms; shift of the cytokine profile towards pro-inflammatory factors (IL-1b, IL-2, IL-8, IL-6) was registered in bacterial and viral RS and towards the values of anti-inflammatory IL-4 - in fungal RS. The increased amount of chaperone proteins was seen in bacterial RS; high concentration of antibodies against them was noted in fungal and viral RS.

[Influence of exam stress on the development of endothelial dysfunction and the formation of platelet-leukocyte coagregates].

The aim of this work was to study the qualitative and quantitative composition of circulating endotheliocytes, P-selectin-associated leukocyte and platelet of coogregation blood levels of endothelin, interleukin-6 students on the background of exam stress. The research was made on the group conditionally healthy volunteers aged MT 18.3 ± 1 years that before participating in the study had a medical examination (n = 15). Blood sampling was made three times: 1--three months before the session (in a normal school day, two hours after training sessions), 2--for 25 ± 10 min before the exam, 3 - 15 ± 10 min after the exam. Approved the development of endothelial dysfunction in the background of exam stress, manifested by increased levels of circulating endothelial cells and endothelin. The total number of leukocyte and platelet of coogregation during the semester, before and after the exam has not changed, while there was an increase outlets, due to the expression of P-selectin on red blood cells before the exam and precipitous decline after the exam.