RESUMO
The plasma levels of interleukin (IL)-1 beta, and IL-6, and IL-10 were studied in 46 patients with acute viral hepatitis B and in 18 patients with acute viral hepatitis C at the peak of the disease during early and late convalescence. There was a significant increase in the levels of IL-1 beta and IL-6 and a reduction in the concentrations of IL-10, which was most evident at the peak of the disease in patients with acute viral hepatitis C as compared with those with hepatitis B.
Assuntos
Hepatite B/sangue , Hepatite C/sangue , Interleucina-10/sangue , Interleucina-1beta/sangue , Interleucina-6/sangue , Doença Aguda , HumanosRESUMO
AIM: To study the activity of antioxidative defense enzymes and the total plasma antioxidative activity in patients with viral hepatitis B, C, and mixed hepatitis B + C. MATERIALS AND METHODS: 77 patients with viral hepatitis B, 90 with viral hepatitis C, and 25 with mixed hepatitis B + C were followed up. The activity of superoxide dismutase and catalase of leukocytes, and the total plasma antioxidative activity were determined at the peak of the disease, alleviation of clinical symptoms, and before discharge from hospital. RESULTS: At the peak of the disease, the patients with viral hepatitides showed suppressed activities of superoxide dismutase and catalase of leukocytes and suppressed total plasma antioxidative activity with increased these parameters by early convalescence, but without their normalization. There were the most pronounced changes in patients with severe mixed hepatitis B + C. CONCLUSION: The changes found in the body's antioxidative defense have been ascertained to depend on the etiology, stage, and severity of viral hepatitis.
Assuntos
Catalase/metabolismo , Hepatite Viral Humana/enzimologia , Superóxido Dismutase/metabolismo , Doença Aguda , Adolescente , Adulto , Idoso , Catalase/sangue , Hepatite B/enzimologia , Hepatite B/virologia , Hepatite C/enzimologia , Hepatite C/virologia , Hepatite Viral Humana/sangue , Hepatite Viral Humana/virologia , Humanos , Leucócitos/enzimologia , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Superóxido Dismutase/sangueRESUMO
Serum MDA level and concentration of superoxide anion in leukocytes were measured in patients with acute hepatitis B and C at the peak of the disease, during regression, and during early convalescence. The concentration of active oxygen forms in leukocytes was maximum at the peak of the disease and decreased before discharge from the hospital.
