1.
Antibiot Khimioter
; 35(8): 12-3, 1990 Aug.
Artigo
em Russo
| MEDLINE
| ID: mdl-2176073
RESUMO
A simple method for synthesis of S-sulfoxides of penicillanic acid and 6 alpha-bromo- and 6 alpha-chloropenicillanic acids is described. The S-sulfoxides were synthesized by the respective oxidation with 30% hydrogen peroxide at 0 degrees C in the absence of solvents. 1 mol of penicillanic acid and 1.5 to 2 mol of 6 alpha-bromo- or 6 alpha-chloropenicillanic acid were required. The yields of S-sulfoxides of 6 alpha-bromo- and 6 alpha-chloropenicillanic acids amounted to 55 and 50%, respectively, based on 6-aminopenicillanic acid. The yield of penicillanic acid S-sulfoxide was 80% based on penicillanic acid. The purity of the compounds was more than 95%.
Assuntos
Peróxido de Hidrogênio/farmacologia , Ácido Penicilânico/síntese química , Sulfóxidos/síntese química , Inibidores de beta-Lactamases , Ácido Penicilânico/química , Espectrofotometria Infravermelho/métodos , Sulfóxidos/química
2.
Pharmazie
; 43(5): 363, 1988 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3174815
3.
Pharmazie
; 40(10): 730, 1985 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4080791