[Diagnostic value of chromato-mass-spectrometry in patients with drug-induced jaws osteonecrosis]. / Kliniko-diagnosticheskoe znachenie khromato-mass-spektrometrii pri medikamentoznom osteonekroze cheliustei.

In patients with drag-induced jaw osteonecrosis which developed in cancer patients due to administration of bisphosphonates for metastases, the microflora of the oral cavity was examined by chromatography-mass spectrometry (HMS). The method of HMS can be used as an additional method of diagnostics in complex clinical cases with ineffective treatment.

[The expression of TLR4 and HBD3 in epithelial cells of oral mucosa by surgical treatment of periodontitis]. / Ekspressiya genov TLR4 i HBD-3 v epitelial'nykh kletkakh slizistoi obolochki pri khirurgicheskom lechenii parodontita.

The expression of TLR4 and HBD3 in epithelial cells of the oral cavity was studied using polymerase chain reaction in real-time in patients with inflammatory and destructive periodontal lesions before and after surgery using osteoplastic material. Analysis of TLR4 and HBD3 expression in epithelial cells demonstrates the key role of the innate immune factors in the pathogenesis of inflammatory and destructive periodontal lesions. TLR4 gene expression was increased 1.5-7.0 times and HBD3 1.5-5.0 times compared to healthy individuals. Surgical treatment resulted in an effective rehabilitation and normalization of innate immunity.