[The dynamics of biochemical blood indicators in patients with hemophilia and posttransfusion hepatitis receiving hepatotropic therapy].

The sample of 128 patients with hemophilia aged from 1 to 71 years (Me 32) was examined. The study established that 109 patients (85.2%) had hemophilia A and 19 patients (14.8%) had hemophilia B. In 77 adult patients (60%) markers of viruses of hepatitis C and B were detected and the signs of disorders of liver functions were established in 64% out of them. These signs included reliable increasing of levels of AST and ALT, total and conjugated bilirubin, urea and creatinine and absence of any clinical manifestations. The detected alterations served as a background for implementation of hepatotropic therapy with pharmaceutical Heptral. The ademetionin is the reactant of preparation. After two weeks of intravenous application of Heptal the tendency to normalization of content of bilirubin was established. The significant decrease of activity of aminotransferases was detected, nevertheless their levels still overridden physiological standard. This situation required to prescribe pharmaceutical and to continue treatment in out-patient conditions. The continuous repair of functional activity of hepatic cells requires further search of more effective schemes of therapy.

[The IgG subclasses in patients with inhibitory form of hemophilia infected and noninfected with viruses].

The sample consisted of 102 patients with hemophilia infected and non-infected with hepatitis viruses. It is established that in case of inhibitory form of hemophilia concentration of IgG increases at the expense of subclass II and in case of non-inhibitory form of hemophilia valuable increase of concentration of IgG occurs at the expense of subclasses I, II and III under concomitant chronic hepatitis. No significant differences between these groups in levels of antibodies to factors VIII and IX is established.

[Evaluation of methods of studying hemostasis]. / Otsenka nekotorykh metodov issledovaniia gemostaza.

Comparative assessment of the methods for studies of platelet aggregation, used in the USSR and in Hungary, has demonstrated the usefulness and reproducibility of both. The reagents manufactured by Reanal (Hungary) are characterized by a higher sensitivity, inducing a more distinct and rapid formation of aggregates. This fact is of particular importance when no aggregometers are available and the 'snow whirl' is assessed visually. Another advantage of the Hungarian aggregants is the presence of the whole set of reagents in the kit and standardization of these reagents. Assessment of the activated partial thromboplastin time of mixed donor native plasma with the use of the Soviet native partial thromboplastin stored frozen and with the use of the Reanal reagent has demonstrated a high variability of the results; this may be explained by the employment of nonstandard reference plasma. The advantages of the imported lyophilized reagent are a year's shelf life and the possibility of transportation.