[Markers of periodontal diseases and sensitivity to taromentine in patients with aggressive periodontitis].

The aim of the research was to study sensitivity of specific microorganisms from the periodontal pockets of patients with rapidly progressive periodontal disease to Taromentine. 95 patients aged 21 to 35 years (50 women (52,6+/-33,62) and 45 men (47,36+/-3,62)) with rapidly progressive form of periodontal desease were observed. Porphiromonas gingivalis was identifide in 83 out of 95 patients (87,36+/-2,06). Prevotella intermedia - in 31 patients (32,6+/-2,750); Actinobacillus actinomycetemcomitans - in 23 patients (24,2+/-2,050); Bacteroides forsythus - in 19 patients (20,0+/-2,360); Treponema denticola - in 16 patients (16,84+/-2,190); Candida - in 11 patients (11,57+/-1,80). The sensitivity of all cultures to Taromentine was investigated: 134 (77,9+/-1,89) out of 183 identified markers demonstrated sensitivity to Taromentine. Demostrated sensitivity to Taromentine: 64 (37,2+/-1,06) out of 83 identified cultures of Porphiromonas gingivalis, 24 (13,95+/-1,85) out of 31 identified cultures of Prevotela intermedia, 18 (10,47+/-1,05) out of 23 identified cultures of Actinobacillus actinomycetemcomitans, 15 (8,7+/-1,86) out of 19 identified cultures of Bacteroides forsythus, and 13 (7,84+/-1,09) out of 16 identified cultures of Treponema denticola. Totally 38 (22,1+/-1,59) out of 172 identified periodontal markers demonstrated resistence to Taromentine. The results of analysis showed that Taromentine could be recommended in complex treatment of periodontal diseases.

[Etiologic factors in development of inflammatory diseases (cheilitis) of the lips].

Last years the number of patients affected with lips' pathologies has been significantly increased that could be caused by different exogenic (chemical, biological, pharmacological and toxic substances etc.) and endogenic factors. Therefore, considering the above-mentioned etiologic factors, the aim of our study was identification and differentiation of different types of Cheilitis and basing on the study of their pathogenesis, to perform differential diagnostics and to systematize them. In certain cases, cheilitis appeared to be the early manifestations of diseases of different organs or organ systems on lips, laying the great responsibility on the Doctor-Stomatologists, who together with the other appropriate specialists is obliged to perform diagnostics of general (background) diseases in time; to make differential diagnostics and to plan the further and target therapy.

[Content and metabilism of nitric oxide in substrates of oral cavity and their role in pathogenesis of periodontite disease].

Content and metabolism of free NO in saliva, fluids of periodontal pockets and gingival tissue has been investigated by EPR (electron paramagnetic resonance) method with the use of nitric oxide spin-trap in patients suffering from periodontitis. It was found that increased generation of nitric oxide at early stages of periodontitis is of protective nature. However, at serious disorders of mitochondrial respiration and exaggerated formation of generators of reactive oxygen, nitric oxide converts into citotoxic peroxinitrite leading to destruction of parodontal tissue; part of free nitric oxide produces FeSNO, which in turn, supports and decreases content of free NO in gingival tissue. As a result, decreases local antimicrobial protection, hemocirculation, tissue nutrition, progresses inflammation. Periodontitis decreases local immunity due to NO deficiency in gingival tissue. Reduced content of NO in gingival tissue decreases regeneration ability of cells, which in turn, leads to deterioration on gingival tissue.

[Antibacterial nature of medicinal ointments, based on Georgian mineral waters in treatment of generalized periodontitis].

The goal of the work was to determine antibacterial nature of the medicinal ointments (N1 - "Achtala"; N2 - "Sairme", N3 - "Tschaltubo", N4 "Amagleba") based on Georgian mineral waters and containing bio-active extracts. The goal of the work was to determine antibacterial nature of the medicinal ointments (N1 - "Achtala"; N2 - "Sairme", N3 - "Tschaltubo", N4 "Amagleba") based on Georgian mineral waters and containing bio-active extracts. The investigation was done in purpose to determine microbial structure of oral cavity of the 80 patients with chronic generalized periodontitis, as a result was confirmed, that microbial structure of these patients was rather heterogeneous and is presented by different aerobe, microaerophil and anaerobe microbial flora. The sensitivity, resistance, of isolated microorganisms, was studied to modern groups of antibiotics. Results of investigations are: high antibacterial activities of ointments, prepared on mineral waters of Georgia. So, it can be recommended for usage in treatment schedule for patients with chronic generalized periodontitis.

[Role of various etiologic factors in the development of burning mouth syndrome].

Burning mouth syndrome (BMS) has been comparatively recently isolated as the separate nosologic diagnosis. This disease is characterized by the feeling of burning, dryness, numbness, pricking and seldom by pain in the tongue or mouth cavity area (palate, lips, alveoli) without any changes in mucous membrane. Absence of visible causes of the disease complicates its treatment and makes the patients to address the physicians of various profiles, often without any result. All the above stated made the authors to define the etiologic factors of various clinical versions of BMS and to carry out their differential diagnostics along with the development of pathogenetic therapy of BMS. 30 women of 40 to 70 year of age were examined. According to the anamnesis, BMS was developing gradually and in most cases it was associated with the aggravation of the existing disease (hypertension, diabetes mellitus, aggravation of climacteric state) or with deterioration of psycho-emotional sphere due to conflicting situation. The carried out studies enabled the authors to select and divide patients with BMS into groups according to clinical values and the etiologic factors. In most cases diverse clinical versions of the burning mouth syndrome are cause-and-effect expressions of various somatic diseases, the timely determination and adequate therapy of which give the best results in the struggle against BMS.