1.
Bioorg Med Chem Lett
; 21(1): 220-4, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21130649
RESUMO
Starting with a subtle blood glucose-lowering effect of a TGF-ß inhibitor, we designed and synthesized a series of benzoylpyrrole-based carboxylic acids as PPARs activators. Among these compounds, 10sNa exhibited favorable blood glucose-lowering effect without body weight gain. We assume that the beneficial effect of 10sNa is attributed to not only its compound PPARα agonistic activity but also its PPARγ partial agonistic activity.