[TSH secretion stimulated by thyroliberin in patients with hypothyroidism receiving 1,25-hydroxyvitamin D3]. / Sekrecja TSH stymulowana tyreoliberyna u chorych z niedoczynnoscia tarczycy otrzymujacych 1,25 (OH)2 witamine D3.

The effect of 1,25-hydroxy vitamin D3 on the secretion of TSH was studied in 49 patients with primary hypothyroidism. The vitamin D3 metabolite did not cause any significant changes in the secretion of TSH both basal and stimulated with TRH in patients with untreated hypothyroidism. In those treated with the synthetic L-thyroxine it produced a significant increase in basal TSH secretion.

[Association of primary autoimmune hypothyroidism with Addison's anemia]. / Wspólistnienie pierwotnej autoimmunologicznej niedoczynnosci tarczycy i choroby Addisona-Biermera.

Intestinal absorption of vitamin B12 as measured by the Schillin test was studied in 50 patients with primary hypothyroidism of autoimmune origin. The impaired absorption of vitamin B12 was found in 24% of the patients studied, and in 6% a clinically evident form of pernicious anemia was diagnosed. The patients with hypothyroidism and simultaneous defect in absorption of vitamin B12 were characterized by more frequent occurrence of the high titer of antithyroid microsomal antibodies, higher blood serum concentration of TSH and lower blood content of hemoglobin as compared with hypothyroid patients having normal intestinal absorption of vitamin B12.

[Effect of propranolol on electrophysiologic features of the heart in patients with hyperthyroidism]. / Wplyw propranololu na wlasciwosci elektrofizjologiczne serca u chorych z nadczynnoscia tarczycy.

The effect of increasing doses of intravenously administered propranolol on electrophysiological features of heart was studied in 17 patients with untreated hyperthyroidism by using the transesophageal stimulation method. A positive and dose-dependent effect of propranolol on the studied parameters was found with the normalization of the majority of disturbances taking place after the administration of 6 mg of propranolol. This dose was safe and well tolerated by the patients. The sensitivity of the auriculo-ventricular junction to propranolol was less pronounced during the stimulated rhythm than during the sinus rhythm.

[Effect of various beta-adrenolytic drugs on heart rate and changes in left-ventricular systolic time intervals in patients with hyperthyroidism and simple goiter]. / Wplyw róznych leków beta-adrenolitycznych na czestosc akcji serca i zachowanie sie podokresów skurczu lewej komory serca u chorych z nadczynnoscia tarczycy oraz wolem obojetnym.

The effects of a short-term application of various beta-adrenolytic drugs on heart rate and on the changes in subperiods of left ventricle contraction have been studied in 71 patients with untreated hyperthyroidism and in 72 patients with simple goiter. The following drugs were used: propranolol, metoprolol, atenolol, pindolol, nadolol and acebutolol. It was found that those betaadrenolytic drugs which have no sympathomimetic action cause a significant decrease in heart rate both in patients with hyperthyroidism and in those with simple goiter. The effect of these drugs on heart rate was not related to the changes in blood serum concentrations of thyroxine and triiodothyronine. None of the drugs tested influenced appreciably the contraction subperiods of left heart ventricle, both in the patients with hyperthyroidism and in those with simple goiter.

[Hypercalciuria in patients with diabetes mellitus type 1 and 2--studies of its pathogenesis using the oral calcium tolerance test]. / Hiperkalciuria u chorych na cukrzyce typu I i II--badania nad patogeneza z zastosowaniem testu doustnego obciazenia wapniem.

The study was aimed at the evaluation of changes in the urinary excretion of calcium in patients with diabetes of type I and II. The investigations were carried out in 34 patients with type I diabetes, 28 patients with type II diabetes and 30 control subjects having the normal glucose tolerance. The oral calcium tolerance test according to Pak was performed in all the patients and the controls. Besides normocalciuria, also hypercalciuria of renal origin, as well as hipercalciuria resulting from an elevated intestinal absorption of calcium have been found in diabetic patients. These disturbances occurred much more frequently in patients with type I diabetes, especially in those of age below 40.

[Effect of various beta-adrenolytic drugs and calcium channel blocker (nifedipine) on selected indicators of calcium-phosphorus metabolism in patients with hyperthyroidism and simple goiter]. / Wplyw róznych leków beta-adrenolitycznych oraz blokera kanalu wapniowego (nifedypiny) na zachowanie sie wybranych wskazników przemiany wapniowo-fosforanowej u chorych z nadczynnoscia tarczycy i wolem obojetnym.

The study was aimed at evaluation of the effect of short-term treatment with one of the six beta adrenolytic drugs (propranolol, metoprolol, atenolol, pindolol, nadolol, acebutolol) and calcium antagonist nifedipine on the values of several parameters of calcium-phosphorus metabolism in 81 patients with hyperthyroidism (14 patients with Graves' disease, and 67 patients with toxic nodular goiter), and 82 patients with simple goiter. The patients studied have been divided into seven groups, each receiving one of the investigated drugs during four days. A significant decrease in the urinary excretion of hydroxyproline was found only in the patients with hyperthyroidism receiving propranolol. This effect of propranolol on hydroxyprolinuria was not related to the degree of lowering of serum T3 concentration observed in these patients.