[Translated article] Comparative study of deep lipomas and atypical lipomatous tumours: Malignancy risk factors.

BACKGROUND AND OBJECTIVES: The diagnostic suspicion of an atypical lipomatous tumour (ALT) is difficult. The aim of this study is to delve into the most controversial diagnostic aspects of the subject. MATERIAL AND METHOD: Observational, longitudinal and retrospective study of a series of 96 deep adipose tumours (75 lipomas and 21 TLA) from 2006 to 2016: demographic, clinical, imaging and pathological variables were analysed and compared, as well as other variables related to treatment and oncological outcomes of the patients. A descriptive analysis of the collected variables was performed for the statistical study. To evaluate the potential predictor variables of malignancy, a multivariate logistic regression analysis was performed, including those that were statistically significant in the univariate analysis. RESULTS: Older age at diagnosis, lower limb location and larger size were significantly more frequent in ALTs. MRI findings showed no statistically significant differences between the two groups. In multivariate analysis, the same clinical variables were confirmed as predictors of malignancy. In the ROC curve, an optimal cut-off point of 134.0mm was used as a predictor of malignancy. CONCLUSIONS: Advanced age, location in the lower limbs and larger size are risk factors for malignancy in the differential diagnosis of deep lipomas and atypical lipomatous tumours. No radiological variable on MRI reached significance as a predictor of malignancy in our series.

Comparative study of deep lipomas and atypical lipomatous tumours: Malignancy risk factors. / Estudio comparativo de lipomas profundos y tumor lipomatoso atípico. Factores pronósticos de malignidad.

BACKGROUND AND OBJECTIVES: The diagnostic suspicion of an atypical lipomatous tumour (ALT) is difficult. The aim of this study is to delve into the most controversial diagnostic aspects of the subject. MATERIAL AND METHOD: Observational, longitudinal, and retrospective study of a series of 96 deep adipose tumours (75 lipomas and 21 TLA) from 2006 to 2016: demographic, clinical, imaging and pathological variables were analysed and compared, as well as other variables related to treatment and oncological outcomes of the patients. A descriptive analysis of the collected variables was performed for the statistical study. To evaluate the potential predictor variables of malignancy, a multivariate logistic regression analysis was performed, including those that were statistically significant in the univariate analysis. RESULTS: Older age at diagnosis, lower limb location and larger size were significantly more frequent in ALTs. MRI findings showed no statistically significant differences between the two groups. In multivariate analysis, the same clinical variables were confirmed as predictors of malignancy. In the ROC curve, an optimal cut-off point of 134.0 mm was used as a predictor of malignancy. CONCLUSIONS: Advanced age, location in the lower limbs and larger size are risk factors for malignancy in the differential diagnosis of deep lipomas and atypical lipomatous tumours. No radiological variable on MRI reached significance as a predictor of malignancy in our series.

Osteochondromas of the Proximal Humerus. Diagnostic and Therapeutic Management. / Osteocondromas del extremo proximal del húmero. Manejo diagnóstico y terapéutico.

OBJECTIVE: 1) To recall the epidemiology and signs of osteochondromas of the proximal humerus (OPH); 2) determine treatment indications; 3) and make recommendations for surgical treatment. METHODS: Retrospective, observational and longitudinal study of 20 solitary and 12 multiple osteochondromas of the proximal humerus. We analyzed the epidemiological, clinical and imaging characteristics and treatment results with an average time of follow-up of the operated cases of 45 months. RESULTS: Eleven (55%) males and 9(45%) females with an average age of 21 years presented solitary osteochondromas. Twelve (60%) cases were operated on at a mean age of 23 years because they were symptomatic or, in one case, malignancy was suspected. Two solitary osteochondromas could have spontaneously regressed. Multiple osteochondromas were found in 11(92%) males and one (8%) female of whom 3required surgery. There were no complications or recurrences. Functional outcome was excellent in all patients. DISCUSSION: Osteochondromas of the proximal humerus are relatively common, although most publications are case reports or short series. CONCLUSIONS: Osteochondromas of the proximal humerus do not differ from those in other locations. Symptomatic cases and those in which malignancy is suspected would be operated, the former preferably at the end of growth. The surgical treatment is summarized in planning the approach, using CT and/or MRI, extraperiosteal en bloc resection, and eventual bone reconstruction, ideally with allograft.

Circuito de asistencia a pacientes con sarcomas de partes blandas de las extremidades: un tortuoso y lento camino hasta las unidades de referencia / Health care circuit for patients with soft tissue sarcomas of the extremities. A tortuous and slow road to referral units

Objetivo: Analizar los tiempos de espera transcurridos desde que los sarcomas de partes blandas (SPB) se hacen sintomáticos hasta su tratamiento específico en nuestra Unidad de Tumores Músculo-Esqueléticos (UTME) para proponer estrategias de mejora en los circuitos de derivación. Material y métodos: Estudio observacional, longitudinal y ambispectivo de una cohorte de 61 pacientes con SPB vírgenes obtenidos e identificados de forma continúa del registro de pacientes de la UTME. Se analizó la relación entre diferentes tiempos transcurridos desde que la enfermedad se hizo sintomática hasta la primera consulta en la UTME, y diversas variables ligadas a la persona, tumor y circuito asistencial. Se usó un nivel de significación _ = 0,05. Resultados: El tamaño medio de los sarcomas fue de 11,3 cm. Treinta y seis pacientes (59%) siguieron el circuito habitual del Sistema Nacional de Salud en nuestro país. El tiempo medio transcurrido desde que la enfermedad se hizo sintomática hasta la primera consulta médica fue superior a 9,5 meses; y el que transcurrió desde esta hasta la primera en nuestra UTME fue de casi 8,5 meses. Algunas variables independientes mostraron relación estadísticamente significativa con las variables dependientes analizadas. Discusión: El estudio muestra que la asistencia a los pacientes con SPB de las extremidades en nuestro medio está muy lejos de los tiempos que transcurren en los países de nuestro entorno. Conclusiones: Parece fundamental la necesidad de concienciar a la población sobre la enfermedad y recordarla entre los profesionales sanitarios, al igual que la existencia de un circuito de derivación que es necesario utilizar (AU)

Objective: To analyse the waiting periods elapsed since soft tissue sarcomas become symptomatic until their specific treatment in our unit, and to determine new strategies for the improvement of referral circuits. Material and methods: This is an ambispective observational study of a cohort of 61 patients, with previously untreated soft tissue sarcomas, obtained from our Musculoskeletal Tumors Database. Several variables related to the patient, tumour, and health care circuit were analysed, as well as the different periods between the initial symptoms of the disease and the first consultation in our unit. The significance level was _=0.05. Results: The mean size of the sarcomas was 11.3 cm. Thirty-six patients (59%) followed the usual circuit of the National Health System in Spain. The time elapsed since the disease became symptomatic until the first medical consultation was greater than 9.5 months, and nearly another 8.5 months to the consultation in our specific unit. Statistically significant relationships were found between the independent and dependent variables. Discussion: The study shows that the care of patients with soft tissue sarcomas in our environment is far away from the times of care in our neighbouring countries. Conclusions: It is essential to make the population and health professionals aware of this disease, as well as to remember that there is a referral circuit that must be used (AU)

[Health care circuit for patients with soft tissue sarcomas of the extremities. A tortuous and slow road to referral units]. / Circuito de asistencia a pacientes con sarcomas de partes blandas de las extremidades: un tortuoso y lento camino hasta las unidades de referencia.

OBJECTIVE: To analyse the waiting periods elapsed since soft tissue sarcomas become symptomatic until their specific treatment in our unit, and to determine new strategies for the improvement of referral circuits. MATERIAL AND METHODS: This is an ambispective observational study of a cohort of 61 patients, with previously untreated soft tissue sarcomas, obtained from our Musculoskeletal Tumors Database. Several variables related to the patient, tumour, and health care circuit were analysed, as well as the different periods between the initial symptoms of the disease and the first consultation in our unit. The significance level was α=0.05. RESULTS: The mean size of the sarcomas was 11.3 cm. Thirty-six patients (59%) followed the usual circuit of the National Health System in Spain. The time elapsed since the disease became symptomatic until the first medical consultation was greater than 9.5 months, and nearly another 8.5 months to the consultation in our specific unit. Statistically significant relationships were found between the independent and dependent variables. DISCUSSION: The study shows that the care of patients with soft tissue sarcomas in our environment is far away from the times of care in our neighbouring countries. CONCLUSIONS: It is essential to make the population and health professionals aware of this disease, as well as to remember that there is a referral circuit that must be used.

[Intramuscular lipomas: Large and deep benign lumps not to underestimated. Review of a series of 51 cases]. / Lipomas intramusculares: bultos benignos grandes y profundos. Revisión de una serie de 51 casos.

OBJECTIVE: To review a poorly studied pathology in the scientific literature. MATERIAL AND METHODS: An observational, longitudinal and ambispective study of a series of 51 intramuscular lipomas in 50 patients. The frequency distribution of qualitative variables, and the median and the interquartile range (IQR) for continuous variables were calculated. The relationship between the size of the lipomas (recoded into two values) and the study variables were analyzed using the Fisher exact test. RESULTS: Men made up 62% of the series, and the median age was 61 years, with 55% of the total being overweight. About half of the patients were diagnosed in the upper limb. More than three-quarters (78%) were strictly intramuscular lipomas. Location, clinical and image presentation, treatment and results are described. DISCUSSION: Intramuscular lipomas have their own particular characteristics. Nevertheless, MRI is sometimes unable to distinguish them from well differentiated liposarcomas. Using size as the only criterion for referring a patient with a soft tissue injury to a reference center is still debatable. CONCLUSIONS: Patients with intramuscular lipomas, although they may be typical in their presentation, especially when they are large and show findings that can be confused with a well-differentiated low grade liposarcoma, should be treated in experienced centers.

Colitis colágena. Estudio clinicopatológico de 18 casos / Collagenous colitis. Clinicopathological study of 18 cases

Introducción. La colitis colágena (CC) es una entidad poco frecuente y de buen pronóstico que desde un punto de vista clínico pertenece al grupo de las diarreas crónicas acuosas. Objetivo. Analizar las características epidemiológicas, clínicas y evolutivas de un grupo de 18 pacientes diagnosticados de CC, así como la respuesta al tratamiento. Material y métodos. Se realiza un estudio retrospectivo de las biopsias endoscópicas de colon realizadas en el Hospital de León durante 5 años, seleccionándose las que cumplen los criterios histológicos de CC. Resultados. Se obtiene un total de 18 casos con una incidencia de 1,25/10 5 habitantes/año. La edad media era de 66,7 años, sin encontrarse diferencias de sexo. El tiempo hasta el diagnóstico fue de 10 meses y existe una posible relación con la toma de antiinflamatorios no esteroideos (46%), lansoprazol (42,8%), tabaquismo (41,6%), así como con enfermedades autoinmunes (30,7%). Hubo respuesta favorable al tratamiento con mesalazina en 2 de los 3 pacientes tratados con ésta y los 2 pacientes tratados con budesonida evolucionaron de forma favorable. Conclusiones. Es importante la toma de múltiples biopsias de colon ante un caso de diarrea crónica acuosa para realizar el diagnóstico de la CC, aun cuando la endoscopia sea normal. En la etiología pueden estar implicados ciertos fármacos y enfermedades autoinmunes

Introduction. Collagenous colitis (CC) is an uncommon disease with a favorable prognosis. It is included in the group of chronic watery diarrheas. Objective. To study epidemiological and clinical characteristics of CC, as well as its course and response to the treatment. Material and methods. This is a descriptive, retrospective study of the endoscopic colon biopsies performed in Hospital de León during 5 years. Those biopsies that fulfilled the histological criteria of CC were selected. Results. A total of 18 cases with an incidence of 1.25/10 5 inhabitants/year was obtained. Mean age was 66.7 years. There was no difference between both genders. The period of time to diagnosis was long (10 months). A possible association with intake of some drugs, as non-steroidal antiinflamatory drugs (46%) and lansoprazole (42.8%), and smoking (41.6%), as well as autoimmune disease (30.7%) was found. There was a good response to the treatment with mesalazine in 2 of 3 patients who received this treatment. The clinical course was also favorable for the 2 patients treated with budesonide. Conclusion. It is important to take multiple biopsies of the colon in order to diagnose CC when there is a case of chronic watery diarrhea even when the colonoscopy is normal. Certain drugs and autoimmune diseases may be involved in the etiology

[Collagenous colitis. Clinicopathological study of 18 cases]. / Colitis colágena. Estudio clinicopatológico de 18 casos.

INTRODUCTION: Collagenous colitis (CC) is an uncommon disease with a favorable prognosis. It is included in the group of chronic watery diarrheas. OBJECTIVE: To study epidemiological and clinical characteristics of CC, as well as its course and response to the treatment. MATERIAL AND METHODS: This is a descriptive, retrospective study of the endoscopic colon biopsies performed in Hospital de León during 5 years. Those biopsies that fulfilled the histological criteria of CC were selected. RESULTS: A total of 18 cases with an incidence of 1.25/10(5) inhabitants/year was obtained. Mean age was 66.7 years. There was no difference between both genders. The period of time to diagnosis was long (10 months). A possible association with intake of some drugs, as non-steroidal antiinflammatory drugs (46%) and lansoprazole (42.8%), and smoking (41.6%), as well as autoimmune disease (30.7%) was found. There was a good response to the treatment with mesalazine in 2 of 3 patients who received this treatment. The clinical course was also favorable for the 2 patients treated with budesonide. CONCLUSION: It is important to take multiple biopsies of the colon in order to diagnose CC when there is a case of chronic watery diarrhea even when the colonoscopy is normal. Certain drugs and autoimmune diseases may be involved in the etiology.

[Xanthogranulomatous cystitis: report of a case]. / Cistitis xantogranulomatosa: presentación de un caso.

OBJECTIVE: To report a case of xanthogranulomatous cystitis, a rare disease especially in the western countries (12 of the 16 cases reported were Japanese and Korean). METHODS: A case of xanthogranulomatous cystitis in a 34-year-old female is presented. Patient evaluation included histological, histochemical and immunohistochemical studies. RESULTS/CONCLUSIONS: The lesion was localized to the bladder dome, anatomically related with the urachus. It consisted of collections of histiocytes with lymphoplasmocytic infiltrate. The adhesions observed in the omentum in this case indicate a possible relationship with a previous inflammatory process. Surgery is advocated in most of the cases with good results.

Embolization of mesothelial cells in lymphatics: the route to mesothelial inclusions in lymph nodes?

AIMS: To provide evidence that lymphatic embolization is the mechanism for mesothelial inclusions in lymph nodes. METHODS AND RESULTS: A 60-year-old man with alcoholic cirrhosis and ascites had an umbilical hernia resected. The herniorrhaphy specimen contained numerous dermal and submesothelial lymphatic vessels filled by cells similar to the cells that lined the hernia sac. Most of the cells in lymphatics were submesothelial reactive cells, whose cytoplasm stained with antibodies against cytokeratins (AE1-AE3; 8, 18), smooth muscle actin, vimentin, desmin and tissue polypeptide antigen (TPA). Some cells seemed to be superficial mesothelial cells, being positive with high molecular weight anticytokeratin antibody 34 beta E12. On ultrastructural study submesothelial cells with intermediate cytoplasmic filaments, rough endoplasmic reticulum and primitive cell junctions, and scanty superficial mesothelial cells with microvilli, tonofilaments and desmosomes were found in the lymphatics. CONCLUSIONS: Lymphatic dissemination of mesothelial and submesothelial cells is an uncommon and not well known phenomenon. Lymphatic dissemination is probably the route by which the mesothelial cells reach the lymphatic nodes. These cells may be mistaken for malignant cells.

[Squamous carcinoma of the esophagus with extensive pagetoid dissemination]. / Carcinoma escamoso de esófago con extensa diseminación pagetoide.

A case of squamous carcinoma of the esophagus with pagetoid spreading in a 59-year-old male in presented. Signs of glandular differentiation (PAS-diastase, Alcian blue) and CEA were negative in the Paget-like cells. Pagetoid spreading of squamous carcinoma and true Paget's disease are very similar histologically and very rare in the esophagus (only 6 cases reported) and they must be differentiated from each other. Paget's disease demonstrates glandular differentiation and the cells are CEA positive. The absence of glandular differentiation in the Paget-like cells of pagetoid spreading versus Paget's disease may be a good criteria to differentiate these diseases.

Atrial rupture and sudden death following atrial infarction.

We present a sudden-death case secondary to a right atrial rupture, occurring as a result of a myocardial infarction with very subtle clinical and electrocardiographical signs. This atrial infarction case illustrates the difficulty of diagnosis and also the serious consequences that can result from this medical condition. We review other potential complications which, in clinical practise, are not always attributed to their true origin.

[Postoperative fusiform cell nodule. Relationship with other benign fibrous proliferations]. / Nódulo de células fusiformes postquirúrgico. Relación con otras proliferaciones fibrosas benignas.

We report on a patient who developed postoperative spindle cell nodule one month following TURP for prostatic adenocarcinoma. The foregoing was compared with other benign fibrous lesions from our records: one case of nodular fasciitis and one case of proliferative myositis. Although they were all well-defined and clinically distinct disease entities, a very close relationship concerning their origin was demonstrated histologically and immunohistochemically.

[Synchronous metastasis of renal adenocarcinoma to gallbladder and ipsilateral adrenal gland]. / Metástasis en vesícula biliar y suprarrenal ipsilateral sincrónica de adenocarcinoma renal.

Herein we describe a patient in whom a renal mass had been detected. He had no previous urological symptoms or signs, but had undergone laryngectomy in 1989 for well-differentiated squamous cell carcinoma of the glottic region. The radiological and ultrasound evaluations disclosed a right renal mass, a mass in the ipsilateral adrenal gland and a polypoid mass in the gallbladder. The patient underwent radical nephrectomy, adrenalectomy and cholecystectomy. The surgical specimens of the gallbladder and adrenal gland showed histological evidence of clear cell carcinoma with the same characteristics as those of the primary renal tumor.