1.
Org Lett
; 13(13): 3360-3, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21615128
RESUMO
Total synthesis of the proposed structure 2 for phomopsin B was achieved by using an intramolecular olefin metathesis as a key step. The spectral data, however, did not match with those of the natural product reported. Re-examination of the reported NMR data led to the structural revision of phomopsin B to known dothiorelone A 18. The R configuration of dothiorelone A was determined by total synthesis through a cross-metathesis with a chiral olefin 19.