RESUMO
The subjects of the study were 14 patients with bronchial asthma (BA) and 11 patients with chronic obstructive pulmonary diseases (COPD). A special diagnostic approach, including spirography with a broncholytic test after inhalation loading (IL), was developed and applied to these patients in order to optimize diagnostics and differentiation diagnostics of BA. IL included the use of hypertonic sodium chloride solution inhalation. The control group consisted of 10 patients with non-obstructive chronic bronchitis and 22 healthy individuals. The results show that bronchial reaction to IL is different in patients with BA and COPD, and demonstrate that this diagnostic approach is appropriate when evaluating the peculiarities of bronchial patency. This allows more accurate diagnostics and differential diagnostics of BA and COPD, optimization of patient grouping for scientific studies, including genetic ones, and is interesting from the perspective of therapy prediction in patients with these diseases.
Assuntos
Asma/diagnóstico , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Testes de Provocação Brônquica/métodos , Bronquite Crônica/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Modelos Biológicos , Cloreto de Sódio/uso terapêutico , Espirometria , Fatores de TempoRESUMO
The first derivative of the integral tetrapolar rheogram of the body, body impedance recording, was found to show changes in blood flow in the arterial compression chamber. Evidence was given for a close relation of the distance between the electrodes while recording an integral rheogram of the body and the examinees' height. The relation of the distance to the examinees' height was equal in males and females and proved to be lower than that previously applied. For calculation of the stroke blood volume from the body impedance recording, the Kubicek equation was proposed to be used by introducing the height of an examinee instead of the distance between measuring electrodes. There was a good coincidence of results while calculating the stroke volume by impedance recording and Doppler echocardiography.
Assuntos
Pletismografia de Impedância , Volume Sistólico , Adolescente , Adulto , Estatura , Ecocardiografia Doppler , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Cardiovasculares , Fatores SexuaisRESUMO
A study was made of dynamics of the content of colony-forming units (CFU) in the spleen and the bone marrow of the nonirradiated F1 (CBA times C57BL) mice to which polysaccharide (PS) from typhoid bacilli was administered. A method of exogenous colony formation was used in this work. A single PS administration increased the CFU count in the bone marrow (2-2 1/2 times) and in the spleen (3 times). Repeated (6- and 9- time) administration of PS was not more effective than a single one. Apparently PS acted as an inductor which caused proliferation of the stem hemopoietic cells and maintained this process for a definite period of time automatically.
Assuntos
Células-Tronco Hematopoéticas/efeitos dos fármacos , Polissacarídeos Bacterianos/farmacologia , Salmonella typhi/análise , Animais , Medula Óssea/efeitos dos fármacos , Células da Medula Óssea , Divisão Celular/efeitos dos fármacos , Células Clonais , Hibridização Genética , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Baço/citologiaRESUMO
The effect of bacterial polysaccharide on the number of spleen cells producing antibodies against sheep's red cells was investigated in irradiated and unirradiated mice. The polysaccharide increased the number of antibody-producing cells both in lethally irradiated (psi rays) and in unirradiated mice, unimmunized with sheep's red cells. This increase was connected with the stimulation of proliferative processes in the recipient by the polysaccharide.
