[The clinico-pathogenetic importance of evaluating monocyte phagocytic activity in viral hepatitis in children]. / Kliniko-patogeneticheskoe znachenie otsenki fagotsitarnoi aktivnosti monotsitov pri virusnykh gepatitakh u detei.

The phagocytic activity of blood monocytes in healthy donors and in children having virus hepatitis was studied. The cytological analysis of preparations made it possible to identify several variants of phagocytosis. Monocytes in children having the moderate form of acute virus hepatitis at the primary stage of the disease proved to be most active. The phagocytic activity of monocytes was low in chronic virus hepatitis. The treatment of children having acute virus hepatitis B with recombinant alfa-2 interferon restored the capacity of monocytes to phagocytose zymosan, which preceded the clinical manifestations of remission.

[Comparative aspects of the changes in lipid metabolism indicators in lymphocyte and erythrocyte membranes in children with diabetes mellitus]. / Sravnitel'nye aspekty izmenenii pokazatelei metabolizma lipidov v membranakh limfotsitov i éritrotsitov u detei, bol'nykh sakharnym diabetom.

Lipid metabolism in lymphocytes was compared to that in the blood serum and red blood cells. 50 children aged 7 to 15 years suffering from insulin-dependent diabetes mellitus (IDDM) in the phase of decompensation without ketosis were examined. The patients were treated at hospital. 12 healthy children of the same age made up the control group. The changes in the lipid composition of red blood cells were shown to follow "passively" the changes occurring in the lipid composition of the blood serum. On the contrary, the changes in the lipid composition of lymphocyte membranes in IDDM are of "active" nature and may be caused by the displacement of the metabolic changes in lipid to a new pathological level. The changes in the lipid composition of lymphocyte membranes, seen in the phase of IDDM decompensation are one of the main factors responsible for the lowering of lymphocyte function that determines the formation of immunodeficiency followed by the superaddition of infectious diseases.

[Changes in the lipid composition of the lymphocyte membranes and in the reactions of the lymphocytic Fc receptors in obesity]. / Izmeneniia lipidnogo sostava membran limfotsitov i reaktsii limfotsitarnykh Fc-retseptorov pri ozhirenii.

The paper is concerned with a study of a response of lymphocytic Fc receptors (FcR) to modulators regulating their expression (prostaglandins E2 and F2, 2 X 10(-9) M, isoproterenol 10(-5), 10(-6) M) as compared to changes in the lymphocyte membrane lipid composition of patients with obesity of II-III degree with a high blood cholesterol level up to 9-10 nmol/l. Two groups were distinguished among obese patients: "areactive" in which lymphocytic FcR did not respond to modulators, and "reactive" in which FcR responded at least to one of 4 utilized modulators. Research into the lipid spectrum of lymphocytic membranes revealed a significant decrease in the concentration of nonesterified fatty acids in membranes of "areactive" lymphocytes to 4 +/- 0.6% (against the normal level of 8.9 +/- 0.7%). In order to make up completely for immunodeficiency in obesity, lipotropic agents and food rich in polyunsaturated fatty acids could be recommended.

[Analysis of the cellular interaction of 2 transplantable lines in mixed culture]. / Analiz vzaimodeistviia kletok dvukh perevivaemykh linii v smeshannoi kul'ture.

A relationship between two transformed cell lines (L and HEp-2) has been studied at different population densities. L cells were inhibited at a low, but not at a high density. We noted specific cell structures in mixed culture at a low density. Crowded cells did not form such structures at the same conditions. Possible alterations of L cells are discussed.