Photo Luminescence and Radiative Carrier Losses in Monolayer Transition Metal Dichalcogenides.

The carrier losses due to radiative recombination in monolayer transition metal dichalcogenides are studied using fully microscopic many-body models. The density- and temperature-dependent losses in various Mo- and W-based materials are shown to be dominated by Coulomb correlations beyond the Hartree-Fock level. Despite the much stronger Coulomb interaction in 2D materials, the radiative losses are comparable-if not weaker-than in conventional III-V materials. A strong dependence on the dielectric environment is found in agreement with experimental results.

Dual-wavelength channel GHz repetition rate mode-locked VECSEL cavities sourced from a common gain medium.

Mode-locked vertical external cavity semiconductor lasers are a unique class of nonlinear dynamical systems driven far from equilibrium. We present a novel, to the best of our knowledge, experimental result, supported by rigorous microscopic simulations, of two coexisting mode-locked V-cavity configurations sourced by a common gain medium and operating as independent channels at angle controlled separated wavelengths. Microscopic simulations support pulses coincident on the common gain chip extracting photons from a nearby pair of coexisting kinetic holes burned in the carrier distributions.

Work-life balance and online student engagement among registered nurses enrolled in online graduate nursing education: a mixed methods study.

BACKGROUND: There is a growing number of online nursing graduate degree programs to address the professional development needs of working nurses. Work-related antecedents of online student engagement in graduate nursing studies are under-explored in the literature. AIM: The aim of the study is to examine the relationship among demographic and work characteristics, work-life balance (WLB), and online student engagement (OSE) among registered nurses enrolled in online graduate studies. METHODS: This study design is convergent-parallel mixed methods, utilizing a survey approach to collect both quantitative and qualitative data. The target population is students of an online Master of Arts in Nursing program at a university in Cabanatuan City, Philippines. Respondents were recruited via email. Google Forms were used for data collection. Non-parametric, inferential statistical tests were used to examine relationships among variables. Inductive qualitative content analysis was used to draw insights from open-ended responses. RESULTS: A total of 173 graduate students responded to the survey. Quantitative results indicate high levels of WLB (Mdn = 4.8, IQR = 1.5) and OSE (Mdn = 3.7-4.0, IQR = 0.5-1.0). WLB was significantly lower among females (U = 3297.5, p < 0.01). Emotion OSE was significantly higher for respondents with managerial positions (U = 2987.5, p < 0.05). WLB had significant low to moderate positive correlations with the domains of OSE (r = 0.22 to 0.32, p < 0.01). Qualitative findings reveal various appraisals of online learning and factors influencing work-life-study balance, such as work, personal life, and school. CONCLUSION: Work-life balance facilitates better online student engagement among graduate nursing students and is influenced by time management, work (i.e. job environment and stressors), personal (i.e. home life and leisure activities), and university factors (i.e. curriculum, modality, and professors). IMPACT STATEMENT: Empirical evidence on the link between WLB and OSE can inform graduate nursing academics in developing initiatives to ensure the timely completion of the degree program.

Clinical performance and utility: A microsimulation model to inform the design of screening trials for a multi-cancer early detection test.

OBJECTIVES: Designing cancer screening trials for multi-cancer early detection (MCED) tests presents a significant methodology challenge, as natural histories of cell-free DNA-shedding cancers are not yet known. A microsimulation model was developed to project the performance and utility of an MCED test in cancer screening trials. METHODS: Individual natural history of preclinical progression through cancer stages for 23 cancer classes was simulated by a stage-transition model under a broad range of cancer latency parameters. Cancer incidences and stage distributions at clinical presentation in simulated trials were set to match the data from Surveillance, Epidemiology, and End Results program. One or multiple rounds of annual screening using a targeted methylation-based MCED test (GalleriⓇ) was conducted to detect preclinical cancers. Mortality benefit of early detection was simulated by a stage-shift model. RESULTS: In simulated trials, accounting for healthy volunteer effect and varying test sensitivity, positive predictive value in the prevalence screening round reached 48% to 61% in 6 natural history scenarios. After 3 rounds of annual screening, the cumulative proportions of stage I/II cancers increased by approximately 9% to 14%, the incidence of stage IV cancers was reduced by 37% to 46%, the reduction of stages III and IV cancer incidences was 9% to 24%, and the reduction of mortality reached 13% to 16%. Greater reductions of late-stage cancers and cancer mortality were achieved by five rounds of MCED screening. CONCLUSIONS: Simulation results guide trial design and suggest that adding this MCED test to routine screening in the United States may shift cancer detection to earlier stages, and potentially save lives.

Circulating cell-free messenger RNA secretome characterization of primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease characterized by multifocal bile duct strictures. To date, underlying molecular mechanisms of PSC remain unclear, and therapeutic options are limited. METHODS: We performed cell-free messenger RNA (cf-mRNA) sequencing to characterize the circulating transcriptome of PSC and noninvasively investigate potentially bioactive signals that are associated with PSC. Serum cf-mRNA profiles were compared among 50 individuals with PSC, 20 healthy controls, and 235 individuals with NAFLD. Tissue and cell type-of-origin genes that are dysregulated in subjects with PSC were evaluated. Subsequently, diagnostic classifiers were developed using PSC dysregulated cf-mRNA genes. RESULTS: Differential expression analysis of the cf-mRNA transcriptomes of PSC and healthy controls resulted in identification of 1407 dysregulated genes. Furthermore, differentially expressed genes between PSC and healthy controls or NAFLD shared common genes known to be involved in liver pathophysiology. In particular, genes from liver- and specific cell type-origin, including hepatocyte, HSCs, and KCs, were highly abundant in cf-mRNA of subjects with PSC. Gene cluster analysis revealed that liver-specific genes dysregulated in PSC form a distinct cluster, which corresponded to a subset of the PSC subject population. Finally, we developed a cf-mRNA diagnostic classifier using liver-specific genes that discriminated PSC from healthy control subjects using gene transcripts of liver origin. CONCLUSIONS: Blood-based whole-transcriptome cf-mRNA profiling revealed high abundance of liver-specific genes in sera of subjects with PSC, which may be used to diagnose patients with PSC. We identified several unique cf-mRNA profiles of subjects with PSC. These findings may also have utility for noninvasive molecular stratification of subjects with PSC for pharmacotherapy safety and response studies.

The double-edged impact of Internet use on mental health outcomes among Filipino university students: the mediating role of online social support.

Introduction: Evidence supports both the positive and negative effects of Internet use on mental health outcomes, but it remains unclear on the role of online social support in this relationship. This study examined the link between daily hours of general Internet use and bidimensional mental health (BMMH) through the pathway of online social support (OSSS). Methods: Drawing from a sample of 247 Filipino university students, this cross-sectional study tested two simple mediation models that considered mental wellbeing and psychological distress as outcome variables. Results: Findings show that the total effect of Internet use is positive and negative for mental wellbeing and psychological distress, respectively. Online social support mediated the favorable effects of Internet use on BMMH outcomes. However, the introduction of OSSS as a mediator yielded residual direct effects with opposing signs for both models. The resultant inconsistent mediation in the models signifies the double-edged impact of Internet use on mental health, with favorable effects transmitted through online social support. Discussion: Findings highlight the importance of online social support as a pathway to harness the positive effects of Internet on mental health. Recommendations to improve online social support for students are discussed herein.

High-harmonic generation from a subwavelength dielectric resonator.

Higher-order optical harmonics entered the realm of nanostructured solids being observed recently in optical gratings and metasurfaces with a subwavelength thickness. Structuring materials at the subwavelength scale allows us toresonantly enhance the efficiency of nonlinear processes and reduce the size of high-harmonic sources. We report the observation of up to a seventh harmonic generated from a single subwavelength resonator made of AlGaAs material. This process is enabled by careful engineering of the resonator geometry for supporting an optical mode associated with a quasi-bound state in the continuum in the mid-infrared spectral range at around λ = 3.7 µm pump wavelength. The resonator volume measures ~0.1 λ3. The resonant modes are excited with an azimuthally polarized tightly focused beam. We evaluate the contributions of perturbative and nonperturbative nonlinearities to the harmonic generation process. Our work proves the possibility to miniaturize solid-state sources of high harmonics to the subwavelength volumes.

Coulomb enhancement of high harmonic generation in monolayer transition metal dichalcogenides.

High harmonic generation (HHG) in monolayer MoS2 is studied using fully microscopic many-body models based on the semiconductor Bloch equations and density functional theory. It is shown that Coulomb correlations lead to a dramatic enhancement of HHG. In particular, near the bandgap, enhancements of two orders of magnitude or more are observed for a wide range of excitation wavelengths and intensities. For excitation at excitonic resonances, strong absorption leads to spectrally broad sub-floors of the harmonics that is absent without Coulomb interaction. The widths of these sub-floors depend strongly on the dephasing time for polarizations. For times of the order of 10 fs the broadenings are comparable to the Rabi energies and reach one electronvolt at fields of approximately 50 MV/cm. The intensities of these contributions are approximately four to six orders below the peaks of the harmonics.

Student nurses' perceptions and experiences in caring for people living with HIV/AIDS: a qualitative study.

BACKGROUND: Caring for people living with HIV/AIDS (PLWHA) requires clinical experience and quality care delivery skills. This study aimed to explore the perceptions and experiences of nursing students in caring for PLWHAs. METHODS: This qualitative descriptive study interviewed 18 student nurses who had cared for PLWHAs from 14 tertiary hospitals across 7 provinces in China through semi-structured telephone interviews. RESULTS: Two themes emerged from the narratives: student nurses' perceptions and attitudes toward PLWHAs and student nurses' practical experiences with PLWHAs. Five theme clusters were revealed, namely "negative attitudes held before the care-giving," "a series of psychological struggles in care-giving," "favorable attitudes increased after the care-giving," "consensus on care delivery for PLWHAs," and "considerations regarding contamination reduction." CONCLUSIONS: Findings shed light on the development and changes in student nurses' perspectives on PLWHAs throughout their clinical experiences. Student nurses' perceptions and attitudes toward PLWHAs progressed through three distinct stages, and positive changes were observed after care-giving. Participants' perceptions and practical experiences with patients with AIDS enable patients to receive fair and high-quality care and provide valuable insights for nursing educators better prepare HIV nurses.

Global utilization of online information for substance use disorder: An infodemiological study of Google and Wikipedia from 2004 to 2022.

INTRODUCTION: The increasing number of people who use drugs (PWUDs) can be attributed to the rising online sales of drugs and other related substances. Information on drugs and drug markets has also become easily accessible in web-search engines and social media. Aside from providing direct care, nurses have essential roles in preventing substance use disorder. These roles include health education, liaison, and researcher. Thus, nurses must examine and utilize the Internet, where information and transactions related to these substances are increasing. DESIGN/METHODS: This study utilized an infodemiological design in exploring the worldwide information utilization for substance use disorder. Data were gathered from Google Trends and Wikimedia Pageview. The data included relative search volumes (RSV), top and rising related queries and topics, and Wikipedia page views between 2004 and 2022. After describing the data, autoregressive integrated mean averaging (ARIMA) models were used to predict future utilization of online information from Google and Wikipedia. RESULTS: Google trends ranked 37 countries based on the search volumes for substance use disorder. Ethiopia, Finland, the United States, Kenya, and Canada have the highest RSVs, while the lowest-ranked country is Turkey, followed by Mexico, Spain, Japan, and Indonesia. Google searches for substance use disorder-related information increased by more than 900% between 2004 and 2022. In addition, Wikipedia page views for substance use disorder-related information increased by almost 200% between 2015 and 2022. Based on the ARIMA models, RSVs and page views are predicted to increase by about 150% and 120% by December 2025. Top and rising search-related topics and queries revealed that the public increasingly utilized online information to understand specific substances and the possible mental health comorbidities related to substance use disorders. Their recent concerns revolved around diagnostics, specific substances, and specific disorders. CONCLUSION: The Internet can be of paradoxical use in substance use disorder. It has been previously reported to be increasingly used in drug trades, contributing to the increasing prevalence of substance use disorder. Likewise, the present study's findings revealed that it is increasingly utilized for substance use disorder-related information. Thus, nurses and other healthcare professionals should ensure that online information regarding substance use disorders is accurate and up-to-date. CLINICAL RELEVANCE: Nurse informaticists can form and lead Internet- and social-media-based health teams that perform national infodemiological investigations to assess online information. In doing so, they can inform, expand, and contextualize ehealth substance use education and strengthen the accessibility and delivery of substance use healthcare. In addition, public health nurses can collaborate to engage patients and communities in identifying harmful substance use disorder information online and creating culturally-appropriate messages that will correct misinformation and improve ehealth literacy, specifically in substance use disorder.

Capacitation of essential school workers in compliance with Philippine COVID-19 guidelines:A qualitative study

Introduction@#Organizations, including higher education institutions (HEIs), have been mandated to protect employees from the threats of the COVID-19.@*Objective@#This study sought to describe the perceptions of essential school workers (ESWs) of selected HEIs in the southern Manila area in terms of how they were capacitated in compliance with national guidelines.@*Methods@#A total of seven HEIs participated in this qualitative study. Focus group discussions (FGDs) were conducted among four sectors of ESWs: security, maintenance, health services, and office staff. Thematic analysis was used to draw insights from the narratives of the FGDs.@*Results@#Three themes emerged from the FGDs: material capacitation, programmatic capacitation, and issues and challenges.@*Conclusion@#This study highlights that from the perspective of ESWs, HEIs in the southern Manila area exert efforts to comply with IATF guidelines through various expressions of material and programmatic capacitation to protect them from the threat of COVID-19. However, results also demonstrate challenges that deter full compliance and consistent implementation of the guidelines across institutions.

Professional commitment and willingness to care for people living with HIV among undergraduate nursing students: The mediating role of empathy.

BACKGROUND: As future registered nurses, undergraduate students play a vital role in integrated care for acquired immunodeficiency syndrome; hence, there is a need to examine factors that can increase their willingness to care for persons with such conditions. OBJECTIVE: This study examined the relationship among nursing professional commitment, empathy, and willingness to care for people living with human immunodeficiency virus and acquired immunodeficiency syndrome among undergraduate student nurses, and the mediating role of empathy in this relationship. DESIGN: Quantitative, cross-sectional design. SETTINGS: Nursing schools from five provinces of China, including Hunan, Jiangxi, Guangxi, Henan, and Hebei. PARTICIPANTS: A total of 747 undergraduate student nurses were recruited via cluster sampling. METHODS: Online survey was used to collect data. Nursing Willingness Questionnaire, Professional Commitment Scale, and Jefferson Scale of Empathy were the scales used to measure the variables. Structural equation modeling was used to determine significant relationships. RESULTS: Respondents' professional commitment and empathy demonstrated moderate positive associations with willingness to care. Empathy demonstrated a 21 % mediating effect on the effect of professional commitment and willingness to care (p < 0.05). CONCLUSIONS: Findings highlight the enabling role of professional commitment and empathy in improving undergraduate student nurses' willingness to care for persons living with human deficiency virus. Nurse educators can help improve the impact of students' professional commitment on their willingness by using educational strategies that enhance their empathy.

More than a year into the pandemic: Do higher education students still practice protective behaviors against COVID-19?

BACKGROUND: The exponential increase of cases and the emergence of the new COVID-19 variants continue to be a challenge. It remains crucial to assess whether or not minimum health standards against COVID-19 are consistently followed. This study determined the higher education students' practice of protective measures against COVID-19 of more than a year into the pandemic. MATERIALS AND METHODS: A questionnaire web survey, cross-sectional study was conducted among higher education students (n = 2309) of a public university in the Philippines. Data were analyzed using the SPSS software. RESULTS: Results indicated that students generally had a high practice of COVID-19 preventive measures. However, only 45.9% always practice physical distancing measures, and only 35.9% always seek information related to COVID-19 after more than a year into the pandemic. Female, married, graduate level, with a monthly family income of PHP 10,000 and above, and personal knowledge of someone who tested for COVID-19 had a significantly higher practice of COVID-19 protective measures. Older age, higher general self-reported health status, and higher intention to comply with recommended protective health behaviors were significantly correlated with higher practice of preventive measures against COVID-19. CONCLUSION: After more than a year of being into the pandemic, students still practice preventive health behaviors, however, this is not done consistently. As the pandemic is still not over in the country and many parts of the world, continuous monitoring and a reminder to practice minimum protective health protocols are needed to mitigate and prevent the spread of COVID-19.

Predicting nursing students' intention to attend face-to-face classes on school reopening: A theory of planned behavior application.

BACKGROUND: The COVID-19 pandemic has resulted in school closures and the reopening of schools is considered to be a possible approach to start reversing learning deficits. However, the literature is scarce on the determinants of intention to attend face-to-face classes among nursing students. METHOD: This cross-sectional study examined students' intention to attend limited face-to-face classes on school reopening, and its association among the core constructs of the Theory of Planned Behavior. Undergraduate nursing students of one university in the Philippines (n = 322) answered an online questionnaire. Predictor variables were determined by multiple linear regression analysis. RESULTS: Results demonstrated that nursing students had a high intention (4.47 of 5) to attend limited face-to-face classes. First- and second-year students had significantly higher intention to attend limited face-to-face classes than third- and fourth-year nursing students. Multiple regression analysis suggested that attitude (ß = .127, p = .001), subjective norm (ß = .400, p = .000), and perceived behavioral control (ß = .326, p = .000) positively predicted students' intention to attend face-to-face classes. CONCLUSION: As many schools prepare for the gradual reopening of campuses, the different beliefs of students may be considered by nursing schools to better understand students' intention for face-to-face instruction.

On the importance of electron-electron and electron-phonon scatterings and energy renormalizations during carrier relaxation in monolayer transition-metal dichalcogenides.

Anab initiobased fully microscopic many-body approach is used to study the carrier relaxation dynamics in monolayer transition-metal dichalcogenides. Bandstructures and wavefunctions as well as phonon energies and coupling matrix elements are calculated using density functional theory. The resulting dipole and Coulomb matrix elements are implemented in the Dirac-Bloch equations to calculate carrier-carrier and carrier-phonon scatterings throughout the whole Brillouin zone (BZ). It is shown that carrier scatterings lead to a relaxation into hot quasi-Fermi distributions on a single femtosecond timescale. Carrier cool down and inter-valley transitions are mediated by phonon scatterings on a picosecond timescale. Strong, density-dependent energy renormalizations are shown to be valley-dependent. For MoTe2, MoSe2and MoS2the change of energies with occupation is found to be about 50% stronger in the Σ and Λ side valleys than in theKandK' valleys. However, for realistic carrier densities, the materials always maintain their direct bandgap at theKpoints of the BZ.

Nonlinear localization of high energy long wave laser pulses in fully correlated 3D turbulence.

We study the interplay between three-dimensional (3D) fully correlated optical turbulence and nonlinearity in time and 3D space resolved long-wavelength infrared pulsed beam propagation. Here the average self-trapped beam waist exceeds the inner scale in contrast to near-infrared filaments, and we find that their nonlinear self-channeling remains robust even in the presence of strong turbulence. More surprisingly, our simulation results invite a conjecture that in regimes where diffraction and nonlinearity are roughly balanced, turbulence can result in a tighter localization of the nonlinear beam core.

Applicability of multipole decomposition to plasmonic- and dielectric-lattice resonances.

Periodic nanoparticle arrays have attracted considerable interest recently since the lattice effect can lead to spectrally narrow resonances and tune the resonance position in a broad range. Multipole decomposition is widely used to analyze the role of the multipoles in the resonance excitations, radiation, and scattering of electromagnetic waves. However, previous studies have not addressed the validity and accuracy of the multipole decomposition around the lattice resonance. The applicability of the exact multipole decomposition based on spherical harmonics expansion has not been demonstrated around the lattice resonance with the strong multipole coupling. This work studies the two-dimensional periodic arrays of both plasmonic and dielectric nanospheres and compares the multipole decomposition results with the analytic ones around their lattice resonances. We study both the effective polarizabilities of multipoles and the scattering spectra of the structures. The analytical results are calculated from the coupled dipole-quadrupole model. This study demonstrates that the exact multipole decomposition agrees well with the numerical simulation around lattice resonances. Only a small number of multipoles are required to represent the results accurately.

Supposedly identical microplastic particles substantially differ in their material properties influencing particle-cell interactions and cellular responses.

Microplastics and its putative adverse effects on environmental and human health increasingly gain scientific and public attention. Systematic studies on the effects of microplastics are currently hampered by using rather poorly characterised particles, leading to contradictory results for the same particle type. Here, surface properties and chemical composition of two commercially available nominally identical polystyrene microparticles, frequently used in effect studies, were characterised. We show distinct differences in monomer content, ζ-potentials and surface charge densities. Cells exposed to particles showing a lower ζ-potential and a higher monomer content displayed a higher number of particle-cell-interactions and consequently a decrease in cell metabolism and proliferation, especially at higher particle concentrations. Our study emphasises that no general statements can be made about the effects of microplastics, not even for the same polymer type in the same size class, unless the physicochemical properties are well characterised.

PARACENTRAL ACUTE MIDDLE MACULOPATHY AS A PRESENTING SIGN OF CENTRAL RETINAL ARTERY OCCLUSION IN SICKLE CELL DISEASE TREATED WITH TISSUE PLASMINOGEN ACTIVATOR.

PURPOSE: We report the case of a 27-year-old monocular woman with a history of sickle cell disease who received intra-arterial tissue plasminogen activator (tPA) after presenting with acute painless vision loss secondary to incomplete central retinal artery occlusion presenting as paracentral acute middle maculopathy in her left eye. METHODS: Ultrawidefield fundus photography, ultrawidefield fluorescein angiography, en face optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) were obtained and reviewed, followed by cerebral angiography and infusion of intra-arterial tissue plasminogen activator. RESULTS: A patient with a history of sickle cell disease presented with a new onset of a dense central scotoma, and the visual acuity diminished to 20 of 200 from baseline 20 of 20 in her left eye. Fluorescein angiogram was nondiagnostic. Optical coherence tomography revealed perifoveal hyper-reflective bands in the inner nuclear layer in a pattern characteristic of paracentral acute middle maculopathy. The patient received intra-arterial tissue plasminogen activator through her left ophthalmic artery shortly after presentation, resulting in a gradual restoration of the visual acuity to 20 of 20 in the three months after the procedure. CONCLUSION: This is the first report describing the use of intra-arterial tissue plasminogen activator to treat incomplete central retinal artery occlusion presenting as a paracentral acute middle maculopathy lesion in a patient with sickle cell disease.