RESUMO
A nationally derived consensus-based core competency set provides perinatal and neonatal nurses a template to guide emergency preparedness and disaster response educational and training activities. Moreover, this consensus-based core competency set allows for the identification and incorporation of measurable objectives that address the learning needs of nurses as well as the unique needs of pregnant women, new mothers, and infants during public health emergencies and disaster events.
Assuntos
Competência Clínica , Consenso , Planejamento em Desastres/organização & administração , Enfermagem Neonatal/organização & administração , Papel do Profissional de Enfermagem , Assistência Perinatal/organização & administração , Planejamento em Saúde Comunitária/organização & administração , Medicina de Desastres/educação , Feminino , Humanos , Comunicação Interdisciplinar , Modelos de Enfermagem , Enfermagem Neonatal/normas , Gravidez , Gestão de Riscos , Estados UnidosRESUMO
The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective ligand for SERT over other monoamine transporters. In this study, a novel library of structurally diverse 4-MTA analogues were synthesised with or without N-alkyl and/or C-alpha methyl or ethyl groups so that their potential SERT-dependent antiproliferative activity could be assessed. Many of the compounds displayed SERT-binding activity as well as cytotoxic activity. While there was no direct correlation between these two effects, a number of derivatives displayed anti-tumour effects in lymphoma, leukaemia and breast cancer cell lines, showing further potential to be developed as possible chemotherapeutic agents.
