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Cells ; 9(9)2020 09 16.
Artigo em Inglês | MEDLINE | ID: mdl-32947824

RESUMO

Background: Staging of atrial fibrillation (AF) is essential to understanding disease progression and the accompanied increase in therapy failure. Blood-based heat shock protein (HSP) levels may enable staging of AF and the identification of patients with higher risk for AF recurrence after treatment. Objective: This study evaluates the relationship between serum HSP levels, presence of AF, AF stage and AF recurrence following electrocardioversion (ECV) or pulmonary vein isolation (PVI). Methods: To determine HSP27, HSP70, cardiovascular (cv)HSP and HSP60 levels, serum samples were collected from control patients without AF and patients with paroxysmal atrial fibrillation (PAF), persistent (PeAF) and longstanding persistent (LSPeAF) AF, presenting for ECV or PVI, prior to intervention and at 3-, 6- and 12-months post-PVI. Results: The study population (n = 297) consisted of 98 control and 199 AF patients admitted for ECV (n = 98) or PVI (n = 101). HSP27, HSP70, cvHSP and HSP60 serum levels did not differ between patients without or with PAF, PeAF or LSPeAF. Additionally, baseline HSP levels did not correlate with AF recurrence after ECV or PVI. However, in AF patients with AF recurrence, HSP27 levels were significantly elevated post-PVI relative to baseline, compared to patients without recurrence. Conclusions: No association was observed between baseline HSP levels and the presence of AF, AF stage or AF recurrence. However, HSP27 levels were increased in serum samples of patients with AF recurrence within one year after PVI, suggesting that HSP27 levels may predict recurrence of AF after ablative therapy.


Assuntos
Fibrilação Atrial/diagnóstico , Fibrilação Atrial/genética , Cardioversão Elétrica/métodos , Proteínas de Choque Térmico/genética , Chaperonas Moleculares/genética , Veias Pulmonares/cirurgia , Adulto , Idoso , Fibrilação Atrial/fisiopatologia , Fibrilação Atrial/cirurgia , Biomarcadores/sangue , Estudos de Casos e Controles , Chaperonina 60/sangue , Chaperonina 60/genética , Progressão da Doença , Feminino , Expressão Gênica , Proteínas de Choque Térmico HSP70/sangue , Proteínas de Choque Térmico HSP70/genética , Proteínas de Choque Térmico/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Proteínas Mitocondriais/sangue , Proteínas Mitocondriais/genética , Chaperonas Moleculares/sangue , Recidiva
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