Sisterhood predicts similar neural processing of a film.

Relationships between humans are essential for how we see the world. Using fMRI, we explored the neural basis of homophily, a sociological concept that describes the tendency to bond with similar others. Our comparison of brain activity between sisters, friends and acquaintances while they watched a movie, indicate that sisters' brain activity is more similar than that of friends and friends' activity is more similar than that of acquaintances. The increased similarity in brain activity measured as inter-subject correlation (ISC) was found both in higher-order brain areas including the default-mode network (DMN) and sensory areas. Increased ISC could not be explained by genetic relation between sisters neither by similarities in eye-movements, emotional experiences, and physiological activity. Our findings shed light on the neural basis of homophily by revealing that similarity in brain activity in the DMN and sensory areas is the stronger the closer is the relationship between the people.

Regionally specific cortical lateralization of abstract and concrete verb processing: Magnetic mismatch negativity study.

The neural underpinnings of processing concrete and abstract semantics remain poorly understood. Previous fMRI studies have shown that multimodal and amodal neural networks respond differentially to different semantic types; importantly, abstract semantics activates more left-lateralized networks, as opposed to more bilateral activity for concrete words. Due to the lack of temporal resolution, these fMRI results do not allow to easily separate language- and task-specific brain responses and to disentangle early processing stages from later post-comprehension phenomena. To tackle this, we used magnetoencephalography (MEG), a time-resolved neuroimaging technique, in combination with a task-free oddball mismatch negativity (MMN) paradigm, an established approach to tracking early automatic activation of word-specific memory traces in the brain. We recorded the magnetic MMN responses in 30 healthy adults to auditorily presented abstract and concrete action verbs to assess lateralization of word-specific lexico-semantic processing in a set of neocortical areas. We found that MMN responses to these stimuli showed different lateralization patterns of activity in the upper limb motor area (BA4) and parts of Broca's area (BA45/BA47) within ∼100-350 ms after the word disambiguation point. Importantly, the greater leftward response lateralization for abstract semantics was due to the lesser involvement of the right-hemispheric homologues, not increased left-hemispheric activity. These findings suggest differential region-specific involvement of bilateral sensorimotor systems already in the early automatic stages of processing abstract and concrete action semantics.

The role of engagement and arousal in emotion regulation: an EEG study.

Cognitive reappraisal and expressive suppression are well-studied strategies of emotion regulation (ER). However, the results on their physiological basis are controversial. While in some studies, ER was accompanied by the inhibition of the nervous system, others suggested that ER even might increase arousal and engagement. We calculated the inter-subject correlation (ISC) and indices of engagement, valence and arousal of EEG during suppression, reappraisal, or natural watching of neutral and negative videos. First, both suppression and reappraisal provoked a higher ISC in comparison with watching negative or neutral videos. We consider this as a marker of engagement to the task and feedback processing required for ER. Second, the engagement index was lower during ER compared to watching negative videos in central electrodes, whereas both strategies provoked a higher engagement in frontal electrodes. Third, the arousal index of EEG was higher during all negative conditions; therefore, regulation required a certain level of arousal. In summary, different EEG measures seem to be sensitive to different aspects of ER.

Visual Stimuli Modulate Local Field Potentials But Drive No High-Frequency Activity in Human Auditory Cortex.

Neuroimaging studies suggest cross-sensory visual influences in human auditory cortices (ACs). Whether these influences reflect active visual processing in human ACs, which drives neuronal firing and concurrent broadband high-frequency activity (BHFA; >70 Hz), or whether they merely modulate sound processing is still debatable. Here, we presented auditory, visual, and audiovisual stimuli to 16 participants (7 women, 9 men) with stereo-EEG depth electrodes implanted near ACs for presurgical monitoring. Anatomically normalized group analyses were facilitated by inverse modeling of intracranial source currents. Analyses of intracranial event-related potentials (iERPs) suggested cross-sensory responses to visual stimuli in ACs, which lagged the earliest auditory responses by several tens of milliseconds. Visual stimuli also modulated the phase of intrinsic low-frequency oscillations and triggered 15-30 Hz event-related desynchronization in ACs. However, BHFA, a putative correlate of neuronal firing, was not significantly increased in ACs after visual stimuli, not even when they coincided with auditory stimuli. Intracranial recordings demonstrate cross-sensory modulations, but no indication of active visual processing in human ACs.

Neural mechanisms of expert persuasion on willingness to pay for sugar.

Introduction: Sugar consumption is associated with many negative health consequences. It is, therefore, important to understand what can effectively influence individuals to consume less sugar. We recently showed that a healthy eating call by a health expert can significantly decrease the willingness to pay (WTP) for sugar-containing food. Here, we investigate which aspects of neural responses to the same healthy eating call can predict the efficacy of expert persuasion. Methods: Forty-five healthy participants performed two blocks of a bidding task, in which they had to bid on sugar-containing, sugar-free and non-edible products, while their electroencephalography (EEG) was recorded. In between the two blocks, they listened to a healthy eating call by a nutritionist emphasizing the risks of sugar consumption. Results: We found that after listening to the healthy eating call, participants significantly decreased their WTP for sugar-containing products. Moreover, a higher intersubject correlation of EEG (a measure of engagement) during listening to the healthy eating call resulted in a larger decrease in WTP for sugar-containing food. Whether or not a participant's valuation of a product was highly influenced by the healthy eating call could also be predicted by spatiotemporal patterns of EEG responses to the healthy eating call, using a machine learning classification model. Finally, the healthy eating call increased the amplitude of the P300 component of the visual event-related potential in response to sugar-containing food. Disussion: Overall, our results shed light on the neural basis of expert persuasion and demonstrate that EEG is a powerful tool to design and assess health-related advertisements before they are released to the public.

Perspective taking in the human brain: complementary evidence from neuroimaging studies with media-based naturalistic stimuli and artificial controlled paradigms.

Perception and interpretation of various types of events and information in life crucially depend on one's perspective. A specific perspective can be explicitly adopted, for example, via instructing an experimental subject, implicitly via a priori information given to subjects, and by subjects' personality traits or cultural background. The neural basis of perspective taking has been addressed in a number of recent neuroimaging studies, some of which have used movies and narratives as media-based stimuli to pursue a holistic understanding of the phenomenon under ecologically valid conditions. Results across these studies suggest that the human brain flexibly adapts to support the information-processing needs of different perspectives, however, also that inferior temporal-occipital areas and posterior-medial parietal areas are engaged across different perspectives. These findings are complemented by studies that have investigated specific aspects of perspective taking with highly controlled experimental designs. They have disclosed involvement of the temporoparietal junction in visual perspective taking and the importance of the affective component of the pain matrix when empathizing with others' pain. Identification with the protagonists also seems to matter, as dorsomedial vs. ventromedial prefrontal areas are recruited when the protagonist is dissimilar vs. similar to self. Finally, as a translational aspect, perspective taking can, under certain conditions, serve as an effective emotion regulation technique, wherein lateral and medial regions of the prefrontal cortex seem to support reappraisal processes. Together, findings from studies with media-based stimuli and more traditional paradigms complement each other to gain a comprehensive understanding of the neural basis of perspective taking.

Similar Cognitive Skill Impairment in Children with Upper Limb Motor Disorders Due to Arthrogryposis Multiplex Congenita and Obstetrical Brachial Plexus Palsy.

Arthrogryposis multiplex congenita (AMC) and obstetrical brachial plexus palsy (OBPP) are motor disorders with similar symptoms (contractures and the disturbance of upper limb function). Both conditions present as flaccid paresis but differ from each other in the pathogenesis: AMC is a congenital condition, while OBPP results from trauma during childbirth. Despite this difference, these diseases are identical in terms of their manifestations and treatment programmes. We compared the cognitive skills of children with AMC and OBPP diagnoses with those of healthy children; we also compared the motor skills of impaired children with those of healthy ones. The patients in both groups significantly differed from the healthy children with regard to psychological parameters, such as 'visual memory capacity' and 'thinking'. Moreover, the two groups with children with AMC and OBPP significantly differed from each other in motor skill parameters, such as 'delayed motor development', 'general motor development', and the 'level of paresis'. Upper limb motor function in the OBPP children was less impaired compared to that of the AMC children. However, we did not find any significant differences in cognitive deficits between the AMC children and the OBPP children. This may indicate that motor impairment is more significant than the underlying cause for the development of cognitive impairment; however, the factors causing this phenomenon require further study (e.g., social environment, treatment, and rehabilitation programme).

Lipreading a naturalistic narrative in a female population: Neural characteristics shared with listening and reading.

INTRODUCTION: Few of us are skilled lipreaders while most struggle with the task. Neural substrates that enable comprehension of connected natural speech via lipreading are not yet well understood. METHODS: We used a data-driven approach to identify brain areas underlying the lipreading of an 8-min narrative with participants whose lipreading skills varied extensively (range 6-100%, mean = 50.7%). The participants also listened to and read the same narrative. The similarity between individual participants' brain activity during the whole narrative, within and between conditions, was estimated by a voxel-wise comparison of the Blood Oxygenation Level Dependent (BOLD) signal time courses. RESULTS: Inter-subject correlation (ISC) of the time courses revealed that lipreading, listening to, and reading the narrative were largely supported by the same brain areas in the temporal, parietal and frontal cortices, precuneus, and cerebellum. Additionally, listening to and reading connected naturalistic speech particularly activated higher-level linguistic processing in the parietal and frontal cortices more consistently than lipreading, probably paralleling the limited understanding obtained via lip-reading. Importantly, higher lipreading test score and subjective estimate of comprehension of the lipread narrative was associated with activity in the superior and middle temporal cortex. CONCLUSIONS: Our new data illustrates that findings from prior studies using well-controlled repetitive speech stimuli and stimulus-driven data analyses are also valid for naturalistic connected speech. Our results might suggest an efficient use of brain areas dealing with phonological processing in skilled lipreaders.

Altered evoked responses for motor-related words in children with upper limb motor impairments.

OBJECTIVE: Obstetric brachial plexus palsy (OBPP) and amyoplasia, the classical type of arthrogryposis multiplex congenita, manifest themselves as highly limited mobility of the upper limb. At the same time, according to the embodiment cognition theories, the motor impairments might lead to the alteration of cognitive functions in OBPP/amyoplasia patients. In the current study, we examined whether OBPP/amyoplasia children exhibit altered processing of motor-related verbs. METHODS: We conducted a case-control study using clinical population and control children. Oddball series were used to elicit mismatch negativity (MMN) EEG responses. The series consisted of limb-related verbs (deviant stimuli) and matched pseudowords (standard stimuli). 27 patients and 32 control children were included in the analysis. RESULTS: We showed that MMN waveforms differed between OBPP/amyoplasia children and their control peers in the frontal and temporal electrodes when the stimuli contained hand-related verbs. In particular, the MMN peak latency in the OBPP/amyoplasia children was significantly delayed as compared with the healthy controls. At the same time, neither series with leg-related verbs nor series of pseudowords resulted in statistically significant differences. CONCLUSIONS: Our findings suggest altered processing of hand-related verbs in OBPP/amyoplasia children with hand-related disabilities. SIGNIFICANCE: Our results contribute to the growing evidence in support of the theory of embodied cognition, which proposes that various domains of cognition are shaped by bodily interactions with the environment.

Altered Cerebral Processing of Videos in Children with Motor Dysfunction Suggests Broad Embodiment of Perceptual Cognitive Functions.

Embodied cognition theory suggests that motor dysfunctions affect cognition. We examined this hypothesis by inspecting whether cerebral processing of movies, featuring both goal-directed movements and content without humans, differ between children with congenital motor dysfunction and healthy controls. Electroencephalography was recorded from 23 healthy children and 23 children with limited or absent arm movement due to either arthrogryposis multiplex congenita or obstetric brachial plexus palsy. Each individual patient exhibited divergent neural responses, disclosed by significantly lower inter-subject correlation (ISC) of brain activity, during the videos compared to the healthy children. We failed to observe associations between this finding and the motor-related content of the various video scenes, suggesting that differences between the patients and controls reflect modulation of perceptual-cognitive processing of videos by upper-limb motor dysfunctions not limited to the watching-mirroring of motor actions. Thus, perceptual-cognitive processes in the brain seem to be more robustly embodied than has previously been thought.

Do sparse brain activity patterns underlie human cognition?

Accumulating multivariate pattern analysis (MVPA) results from fMRI studies suggest that information is represented in fingerprint patterns of activations and deactivations during perception, emotions, and cognition. We postulate that these fingerprint patterns might reflect neuronal-population level sparse code documented in two-photon calcium imaging studies in animal models, i.e., information represented in specific and reproducible ensembles of a few percent of active neurons amidst widespread inhibition in neural populations. We suggest that such representations constitute a fundamental organizational principle via interacting across multiple levels of brain hierarchy, thus giving rise to perception, emotions, and cognition.

"Expert persuasion" can decrease willingness to pay for sugar-containing food.

Recent studies have revealed types of eating nudges that can steer consumers toward choosing healthier options. However, most of the previously studied interventions target individual decisions and are not directed to changing consumers' underlying perception of unhealthy food. Here, we investigate how a healthy eating call-first-person narrative by a health expert-affects individuals' willingness to pay (WTP) for sugar-free and sugar-containing food products. Participants performed two blocks of a bidding task, in which they had to bid on sweets labeled either as "sugar- free" or as "sugar-containing." In-between the two blocks, half of the participants listened to a narrative by a dietary specialist emphasizing the health risks of sugar consumption, whereas the remaining participants listened to a control narrative irrelevant to food choices. We demonstrate that the health expert's narrative decreased individuals' WTP for sugar-containing food, but did not modulate their WTP for sugar- free food. Overall, our findings confirm that consumers may conform to healthy eating calls by rather devaluating unhealthy food products than by increasing the value of healthy ones. This paves the way for an avenue of innovative marketing strategies to support individuals in their food choices.

Processing of an Audiobook in the Human Brain Is Shaped by Cultural Family Background.

Perception of the same narrative can vary between individuals depending on a listener's previous experiences. We studied whether and how cultural family background may shape the processing of an audiobook in the human brain. During functional magnetic resonance imaging (fMRI), 48 healthy volunteers from two different cultural family backgrounds listened to an audiobook depicting the intercultural social life of young adults with the respective cultural backgrounds. Shared cultural family background increased inter-subject correlation of hemodynamic activity in the left-hemispheric Heschl's gyrus, insula, superior temporal gyrus, lingual gyrus and middle temporal gyrus, in the right-hemispheric lateral occipital and posterior cingulate cortices as well as in the bilateral middle temporal gyrus, middle occipital gyrus and precuneus. Thus, cultural family background is reflected in multiple areas of speech processing in the brain and may also modulate visual imagery. After neuroimaging, the participants listened to the narrative again and, after each passage, produced a list of words that had been on their minds when they heard the audiobook during neuroimaging. Cultural family background was reflected as semantic differences in these word lists as quantified by a word2vec-generated semantic model. Our findings may depict enhanced mutual understanding between persons who share similar cultural family backgrounds.

Behavioral Experience-Sampling Methods in Neuroimaging Studies With Movie and Narrative Stimuli.

Movies and narratives are increasingly utilized as stimuli in functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and electroencephalography (EEG) studies. Emotional reactions of subjects, what they pay attention to, what they memorize, and their cognitive interpretations are all examples of inner experiences that can differ between subjects during watching of movies and listening to narratives inside the scanner. Here, we review literature indicating that behavioral measures of inner experiences play an integral role in this new research paradigm via guiding neuroimaging analysis. We review behavioral methods that have been developed to sample inner experiences during watching of movies and listening to narratives. We also review approaches that allow for joint analyses of the behaviorally sampled inner experiences and neuroimaging data. We suggest that building neurophenomenological frameworks holds potential for solving the interrelationships between inner experiences and their neural underpinnings. Finally, we tentatively suggest that recent developments in machine learning approaches may pave way for inferring different classes of inner experiences directly from the neuroimaging data, thus potentially complementing the behavioral self-reports.

Classification of emotion categories based on functional connectivity patterns of the human brain.

Neurophysiological and psychological models posit that emotions depend on connections across wide-spread corticolimbic circuits. While previous studies using pattern recognition on neuroimaging data have shown differences between various discrete emotions in brain activity patterns, less is known about the differences in functional connectivity. Thus, we employed multivariate pattern analysis on functional magnetic resonance imaging data (i) to develop a pipeline for applying pattern recognition in functional connectivity data, and (ii) to test whether connectivity patterns differ across emotion categories. Six emotions (anger, fear, disgust, happiness, sadness, and surprise) and a neutral state were induced in 16 participants using one-minute-long emotional narratives with natural prosody while brain activity was measured with functional magnetic resonance imaging (fMRI). We computed emotion-wise connectivity matrices both for whole-brain connections and for 10 previously defined functionally connected brain subnetworks and trained an across-participant classifier to categorize the emotional states based on whole-brain data and for each subnetwork separately. The whole-brain classifier performed above chance level with all emotions except sadness, suggesting that different emotions are characterized by differences in large-scale connectivity patterns. When focusing on the connectivity within the 10 subnetworks, classification was successful within the default mode system and for all emotions. We thus show preliminary evidence for consistently different sustained functional connectivity patterns for instances of emotion categories particularly within the default mode system.

Developmental differences in the perception of naturalistic human movements.

Introduction: It is widely believed that we are more attentive towards moving versus static stimuli. However, the neural correlates underlying the perception of human movements have not been extensively investigated in ecologically valid settings, nor has the developmental aspect of this phenomenon. Here, we set forth to investigate how human limb movements displayed in naturalistic videos influence the attentional engagement of children and young adults. Methods: Thirty-nine healthy participants (4-26 years old) were presented with naturalistic videos featuring human goal-directed movements, while neural activity was recorded using electroencephalography (EEG). Video scenes were automatically annotated as containing arm, leg or no movement, using a machine learning algorithm. The viewers' attentional engagement was quantified by the intersubject correlation of EEG responses evoked by the videos. Results: Our results demonstrate that scenes featuring limb movements, especially simultaneous arm and leg movements, elicit higher attentional engagement than scenes with no limb movement. Interestingly, this effect was found to diminish with age. Discussion: Overall, our findings extend previous work on the perception of human motion by implementing naturalistic stimuli in the experimental design and extend the list of factors influencing the viewer's engagement exerted by naturalistic videos.

Aberrant Auditory and Visual Memory Development of Children with Upper Limb Motor Disorders.

The current study aimed to compare differences in the cognitive development of children with and without upper limb motor disorders. The study involved 89 children from 3 to 15 years old; 57 children with similar upper limb motor disorders and 32 healthy children. Our results showed that motor disorders could impair cognitive functions, especially memory. In particular, we found that children between 8 and 11 years old with upper limb disorders differed significantly from their healthy peers in both auditory and visual memory scales. These results can be explained by the fact that the development of cognitive functions depends on the normal development of motor skills, and the developmental delay of motor skills affects cognitive functions. Correlation analysis did not reveal any significant relationship between other cognitive functions (attention, thinking, intelligence) and motor function. Altogether, these findings point to the need to adapt general habilitation programs for children with motor disorders, considering the cognitive impairment during their development. The evaluation of children with motor impairment is often limited to their motor dysfunction, leaving their cognitive development neglected. The current study showed the importance of cognitive issues for these children. Moreover, early intervention, particularly focused on memory, can prevent some of the accompanying difficulties in learning and daily life functioning of children with movement disorders.

The Paradox of Fiction Revisited-Improvised Fictional and Real-Life Social Rejections Evoke Associated and Relatively Similar Psychophysiological Responses.

Theatre-based practices, such as improvisation, are frequently applied to simulate everyday social interactions. Although the improvisational context is acknowledged as fictional, realistic emotions may emerge, a phenomenon labelled the 'paradox of fiction'. This study investigated how manipulating the context (real-life versus fictional) modulates psychophysiological reactivity to social rejection during dyadic interactions. We measured psychophysiological responses elicited during real-life (interview) and fictional (improvisation exercises) social rejections. We analysed the heart rate (HR), skin conductance, facial muscle activity, and electrocortical activity (electroencephalographic (EEG) alpha asymmetry) of student teachers (N = 39) during various social rejections (devaluing, interrupting, nonverbal rejection). All social rejections evoked negative EEG alpha asymmetry, a measure reflecting behavioural withdrawal motivation. Psychophysiological responses during real-life and fictional rejections correlated, and rejection type modified the responses. When comparing responses across all rejection types, facial muscle activity and EEG alpha asymmetry did not differ between real-life and fictional rejections, whereas HR decelerated and skin conductance increased during fictional rejections. These findings demonstrate that regardless of cognitive awareness of fictionality, relatively subtle social rejections elicited psychophysiological reactivity indicating emotional arousal and negative valence. These findings provide novel, biological evidence for the application of theatre-based improvisation to studying experientially everyday social encounters.

Neural basis of in-group bias and prejudices: A systematic meta-analysis.

In-group favoritism and prejudices relate to discriminatory behaviors but, despite decades of research, understanding of their neural correlates has been limited. A systematic coordinate-based meta-analysis of functional magnetic resonance imaging (fMRI) studies (altogether 87 original datasets, n = 2328) was conducted to investigate neural inter-group biases, i.e., responses toward in-group vs. out-group in different contexts. We found inter-group biases in some previously identified brain regions (e.g., the medial prefrontal cortex, insula) but also in many previously non-identified brain regions (e.g., the cerebellum, precentral gyrus). Sub-group analyses indicated that neural correlates of inter-group biases may be mostly context-specific. Regarding different types of group memberships, inter-group bias toward trivial groups was evident only in the cingulate cortex, while inter-group biases toward "real" groups (ethnic, national, or political groups) involved broader sets of brain regions. Additionally, there were heightened neural threat responses toward out-groups' faces and stronger neural empathic responses toward in-groups' suffering. We did not obtain significant publication bias. Overall, the findings provide novel implications for theory and prejudice-reduction interventions.