Perspectives on Gender in Science, Technology, and Innovation: A Review of Sub-Saharan Africa's Science Granting Councils and Achieving the Sustainable Development Goals.

Africa's focus on science, technology, and innovation (STI) has grown over the last decade, with emerging examples of good practice. There are however numerous challenges to sustainable development in Africa; for example, inequalities within and among African countries are rising and enormous disparities of opportunity, wealth, and power persist. While policy makers and organizations have put increasing emphasis on integrating gender into STI policies and initiatives as a means to achieve gender equality for all women and girls, inequality remains a key challenge to continental sustainable development. STI funders such as the Science Granting Councils (SGCs) in Africa are key players in national innovation systems. They advise and facilitate policy and program development, disburse funds, build research capacity, set and monitor research agendas, manage bilateral and multilateral STI agreements, and assess the communication, uptake, and impact of research. They, therefore, have a major role to play in enabling countries to achieve SDG5. This study assessed the current actions in gender mainstreaming across the SGCs and the status of gender research and collaboration in participating countries. Our findings provide evidence of uneven progress in promoting gender equality in the operations of the SGCs, including funding research and promoting the integration of gender dimensions in research content and curricula. All SGCs emphasized national commitments to gender, and the importance of gender in STI, but acknowledged that at the structural and institutional levels there was a misalignment between policy and practice. As expected, more men than women were employed across most levels at the SGCs and held positions of seniority and decision making. Most of the SGCs had very limited or no gender-related funding programs to promote gender and STI or to eliminate the barriers that women scholars face. This resulted in persistent inequalities in who received funding, the size of the grants they received, and in the knowledge production, collaboration, and the impact on their country's gender-related research. These findings suggest that SGCs need to strengthen their actions to mainstream gender if they are to achieve success with SDG5.

Physicochemical and biochemical characterization of transgenic papaya modified for protection against Papaya ringspot virus.

BACKGROUND: Papaya, a nutritious tropical fruit, is consumed both in its fresh form and as a processed product worldwide. Major quality indices which include firmness, acidity, pH, colour and size, are cultivar dependent. Transgenic papayas engineered for resistance to Papaya ringspot virus were evaluated over the ripening period to address physicochemical quality attributes and food safety concerns. RESULTS: With the exception of one transgenic line, no significant differences (P > 0.05) were observed in firmness, acidity and pH. Lightness (L*) and redness (a*) of the pulps of non-transgenic and transgenic papaya were similar but varied over the ripening period (P < 0.05). Fruit mass, though non-uniform (P < 0.05) for some lines, was within the range reported for similar papaya cultivars, as were shape indices of female fruits. Transgene proteins, CP and NPTII, were not detected in fruit pulp at the table-ready stage. CONCLUSION: The findings suggest that transformation did not produce any major unintended alterations in the physicochemical attributes of the transgenic papayas. Transgene proteins in the edible fruit pulp were low or undetectable.

Adolescent obesity prevention in Botswana: beliefs and recommendations of school personnel.

The study's objectives were to gain school personnel's (1) perceptions on diet, physical activity, body size, and obesity, (2) description of school food and physical activity practices, and (3) recommendations for programs to prevent adolescent obesity. The study took place in six junior secondary schools of varying socioeconomic status in Gaborone, Botswana. Using a qualitative descriptive design, semistructured interviews were conducted with key school personnel. Directed content analysis was used to summarize the findings. School personnel believed that obesity was an important problem. They felt that school food was unhealthy and that physical activity was provided insufficiently. Participants shared enthusiasm for a school-based health-promoting intervention that must be fun and include active engagement and education on healthy lifestyles for all students. Participants supported on-site food shop inventory changes and physical activity programs. Potential barriers listed were schools' financial resources, interest of students, and time limitations of all involved.

Socio-economic status and urbanization are linked to snacks and obesity in adolescents in Botswana.

OBJECTIVE: To describe patterns of food consumption associated with overweight/obesity (OW/OB) and their links to socio-economic status (SES) and urbanization. DESIGN: A nationwide cross-sectional survey. SETTING: Secondary schools in cities, towns and villages in Botswana, Africa. SUBJECTS: A total of 746 adolescent schoolchildren. RESULTS: OW/OB is associated with greater SES, city residence and a snack-food diet pattern. Students belonging to higher SES compared with those from a lower SES background reported significantly (P < 0·01) more daily servings of snack foods (1·55 v. 0·76) and fewer servings of traditional diet foods (0·99 v. 1·68) and also reported that they ate meals outside the home more often (90% v. 72%). Students in cities ate significantly (P < 0·01) more servings of snacks (1·69 v. 1·05 v. 0·51) and fewer servings of traditional foods (0·67 v. 1·52 v. 1·61) compared with those in urban and rural villages. The odds of OW/OB were increased 1·16-fold with a snack-food diet, a result that was diminished when controlled for SES. CONCLUSIONS: These data suggest that nutritional transition occurs at different rates across urbanization and SES levels in Botswana. In cities, increasing the availability of fruit while reducing access to or portion sizes of snack items is important. Emphasis on continued intake of traditional foods may also be helpful as rural areas undergo economic and infrastructural development.

Tylosema esculentum (Marama) Tuber and Bean Extracts Are Strong Antiviral Agents against Rotavirus Infection.

Tylosema esculentum (marama) beans and tubers are used as food, and traditional medicine against diarrhoea in Southern Africa. Rotaviruses (RVs) are a major cause of diarrhoea among infants, young children, immunocompromised people, and domesticated animals. Our work is first to determine anti-RV activity of marama bean and tuber ethanol and water extracts; in this case on intestinal enterocyte cells of human infant (H4), adult pig (CLAB) and adult bovine (CIEB) origin. Marama cotyledon ethanolic extract (MCE) and cotyledon water extract (MCW) without RV were not cytotoxic to all cells tested, while seed coat and tuber extracts showed variable levels of cytotoxicity. Marama cotyledon ethanolic and water extracts (MCE and MCW, resp.) (≥0.1 mg/mL), seed coat extract (MSCE) and seed coat water extract (MSCW) (0.01 to 0.001 mg/mL), especially ethanolic, significantly increased cell survival and enhanced survival to cytopathic effects of RV by at least 100% after in vitro co- and pre-incubation treatments. All marama extracts used significantly enhanced nitric oxide release from H4 cells and enhanced TER (Ω/cm(2)) of enterocyte barriers after coincubation with RV. Marama cotyledon and seed coat extracts inhibited virion infectivity possibly through interference with replication due to accumulation of nitric oxide. Marama extracts are therefore promising microbicides against RV.

The morama bean (Tylosema esculentum): a potential crop for southern Africa.

The morama bean is an underutilized leguminous oilseed native to the Kalahari Desert and neighboring sandy regions of Botswana, Namibia, and South Africa (Limpopo, North-West, Gauteng, and Northern Cape provinces), and forms part of the diet of the indigenous population in these countries. It is also known as gemsbok bean, moramaboontjie, elandboontjie, braaiboonjie, marama, marumana, tsi, tsin, gami, and ombanui. It is reported as an excellent source of good quality protein (29-39%); its oil (24-48%) is rich in mono- and di-unsaturated fatty acids and contains no cholesterol. Morama is a good source of micronutrients such as calcium, iron, zinc, phosphate, magnesium, and B vitamins including folate. It is also reported to be a potential source of phytonutrients including phenolic compounds (e.g., tannins), trypsin inhibitors, phytates, and oligosaccharides, components which have been shown in other foods to contribute to health in particular, prevention of noncommunicable diseases such as cardiovascular diseases, diabetes, and some cancers. From a nutritional and health perspective, the morama bean has potential commercial value as a cash crop and value-added products, particularly in the communities where it is found.

Ackee (Blighia sapida) hypoglycin A toxicity: dose response assessment in laboratory rats.

Hypoglycin A, the toxin found in the ackee fruit, has been reported in the literature as the causative agent in incidences of acute toxicity termed Jamaican vomiting sickness or toxic hypoglycemic syndrome. Hypoglycin A toxicity in this study was determined by feeding male and female Sprague-Dawley rats a control diet and ackee diets that contained 4-3840 ppm of hypoglycin. The fixed dose method was used to quantify the acute toxic dose of hypoglycin A and was determined by feeding a diet consisting of the lowest hypoglycin A concentration; this was increased to the next highest dose after 24h until toxicity was observed. The maximum tolerated dose (MTD) of hypoglycin A was determined by feeding rats the ackee and control diets over a 30-day period. The acute toxic dose for male and female rats was 231.19+/-62.5 5mg hypoglycinA/kgBW and 215.99+/-63.33 mg hypoglycinA/kgBW, respectively. This was considerably greater than the dose of 100 mg hypoglycin/kgBW reported in a previous study when aqueous hypoglycin was administered orally. The MTD of hypoglycin A in both male and female rats was 1.50+/-0.07 mg hypoglycinA/kgBW/day. These findings suggest that the form in which hypoglycin in ackee is administered could affect the toxicological properties it exhibits. Therefore, for the purpose of a hazard assessment, it may be best administered within the matrix of the fruit, which is the form that humans consume it.

Household food safety awareness of selected urban consumers in Jamaica.

Home interviews of 110 randomly selected householders representing three distinct socio-economic groups in North Central St Andrew, an urban community in Jamaica, were conducted during January-March 1999. Respondents were interviewed about their awareness of safe food handling, risk perception, food handling practices and attitude to food safety issues. The majority of respondents reported a fairly high knowledge of safe food handling practices; however, more than one-half were unfamiliar with the correct procedure for freezing and thawing of foods. Householders were very concerned about the food they purchased for preparation at home, displayed strong concerns about sanitation of food handling establishments, food handlers practices, and the appearance of foods purchased. The majority of respondents had never contacted their local Health Department or the Ministry of Health regarding food safety concerns. Diarrhea, stomach pain, vomiting and nausea were reported as the major symptoms of food-borne illness, while animal foods including dairy, beef, chicken, pork and fish/shellfish were implicated as the main source of food borne illnesses. There were no significant differences (P<0.5) observed between gender and socio-economic groups in the study, except for concern of the appearance of food and shopping options, respectively. These findings raise concerns about consumer food safety knowledge and practices in Jamaica. It is suggested that a national knowledge, awareness and practices survey should be conducted, followed by a properly designed food safety public education campaign, to enhance household food safety awareness in Jamaica.