RESUMO
BACKGROUND: Moderate alcohol consumers have lower rates of cardiovascular disease than abstainers. One proposed mechanism is a beneficial effect on hemostatic parameters, but previous studies have provided conflicting results. METHODS AND RESULTS: We measured levels of fibrinogen, plasma viscosity, von Willebrand factor, factor VII, plasminogen activator inhibitor antigen-1, and tissue plasminogen activator antigen in a cross-sectional analysis of 3223 adults free of cardiovascular disease enrolled in the Framingham Offspring Study. We assessed their alcohol consumption with a standardized questionnaire. Light-to-moderate alcohol consumption was associated with lower levels of fibrinogen, plasma viscosity, von Willebrand factor, and factor VII. This association was most pronounced for consumers of 3 to 7 drinks weekly for viscosity and 7 to 21 drinks weekly for the other hemostatic measures. Alcohol intake of 7 to 21 drinks weekly or more was associated with impaired fibrinolytic potential, reflected by higher levels of plasminogen activator inhibitor antigen-1 and tissue plasminogen activator antigen. Wine drinkers had lower plasminogen activator inhibitor antigen-1 levels than other drinkers, particularly at 3 to 21 drinks weekly, but beverage type did not otherwise consistently affect the results. CONCLUSIONS: Light-to-moderate alcohol consumption is associated with lower levels of coagulatory factors, but higher intake is associated with impaired fibrinolytic potential. These findings are consistent with the hypothesis that a balance between hemostatic and fibrinolytic activity may contribute to the complex relation of alcohol use with coronary heart disease.
Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Consumo de Bebidas Alcoólicas/metabolismo , Hemostasia/fisiologia , Bebidas Alcoólicas/classificação , Viscosidade Sanguínea/fisiologia , Estudos de Coortes , Estudos Transversais , Demografia , Fator VII/análise , Feminino , Fibrinogênio/análise , Fibrinólise/fisiologia , Humanos , Masculino , Massachusetts/epidemiologia , Pessoa de Meia-Idade , Inibidor 1 de Ativador de Plasminogênio/sangue , Inquéritos e Questionários , Ativador de Plasminogênio Tecidual/sangue , Fator de von Willebrand/análiseRESUMO
Lipid profile of sixty survivors of myocardial infarction was studied and these results were compared with hundred age and sex matched controls. Seventy one percent had normal cholesterol (Ch). However, 80% of them had elevated serum Triglyceride (Tg) values. A decreased apolipoprotein A1 (apo A1) with an increased apolipoprotein B (apo B) values were observed in these patients. Ratio of apo A1 to apo B remained significantly low in survivors of myocardial infarction. It was seen that more abnormalities in patients were observed in apolipoprotein concentrations rather than lipoprotein or lipid concentration.
