Convenient semihydrogenation of azoarenes to hydrazoarenes using H2.

The high atom-economical and eco-benign nature of hydrogenation reactions make them much more superior to conventional reduction and transfer hydrogenation. Herein, a convenient and highly selective hydrogenation reaction of azoarenes using molecular hydrogen to access diverse hydrazoarenes is reported. The present catalytic method is general and operationally simple, and it operates under exceedingly mild conditions (room temperature and 1 atm of hydrogen pressure). The reusability of catalysts used in this method is also successfully demonstrated.

Preparation, Spectroscopic Characterization, Theoretical Investigations, and In Vitro Anticancer Activity of Cd(II), Ni(II), Zn(II), and Cu(II) Complexes of 4(3H)-Quinazolinone-Derived Schiff Base.

Herein, we report the synthesis and characterization of a new Schiff base ligand 3-[[(E)-(3-hydroxyphenyl)-methylidene]amino]-2-methyl-quinazolin-4(3H)-one (HAMQ) and its Cd(II), Ni(II), Zn(II), and Cu(II) complexes (C1-C4). The ligand HAMQ was synthesized by reacting 3-hydroxybenzaldehyde and 3-amino-2-methyl-4(3H)-quinazolinone in a 1:1 molar ratio. The structure of the ligand and its complexes (C1-C4) were evaluated using ultraviolet (UV)-visible (Vis) light spectroscopy, 1H-NMR, Fourier-transform infrared (FT-IR) spectroscopy, MS, elemental analysis, conductance data, and thermogravimetric analysis (TGA). The characterization results suggested that the bidentate ligand, HAMQ, coordinated to the metal center through the lactum oxygen and the azomethine nitrogen. Moreover, all the metal complexes were analyzed using powder X-ray diffraction studies, which revealed that all of them belong to a triclinic crystal system. The research was supplemented by density functional theory (DFT) studies on the IR and UV-Vis spectra, as well as the chemical reactivity of the HAMQ and its four metallic derivatives making use of conceptual density functional theory (CDFT) by means of KID (Koopmans in DFT) methodology. The synthesized complexes displayed significant in vitro anticancer activity against human cancer cell lines (HeLa and HCT-115).

Morphometric study of the lumbar pedicle in the Indian population as related to pedicular screw fixation.

STUDY DESIGN: A morphometric study of lumbar vertebral pedicular parameters in cadavers and comparison with previous studies in the literature was conducted. OBJECTIVES: To suggest dimensions for pedicular implants in the Indian population, and to improve the pedicular screw placement technique. SUMMARY OF BACKGROUND DATA: Detailed knowledge of pedicle morphometry is critical for proper placement of a transpedicular screw. The size and shape of the vertebral pedicle vary between different races. Morphometric studies have been conducted in white and nonwhite populations (e.g., Chinese, Koreans). METHODS: The vertebral pedicles at L1-L5 were studied in 20 cadavers by direct roentgenographic and computerized tomographic scan methods. The following parameters were studied: transverse diameter, transverse angle, sagittal diameter, sagittal angle, chord length, interpedicular distance, medial and lateral cortical thickness. RESULTS: Transverse diameter was largest at L5 (16.19 mm) and smallest at L1 (7.05 mm). The transverse angle was largest at L5 (29 degrees) and smallest at L1 (9 degrees). The pedicles were directed cranially in the sagittal plane at all lumber levels except L5. The sagittal angle was largest at L5 (29 degrees) and smallest at L1 (9 degrees). Chord length was largest at L2 (47.5 mm) and smallest at L1 (46.01 mm). The values of linear measurements were smaller in females at all levels. CONCLUSIONS: On the basis of this limited study in a subset of the Indian population, it appears that the transverse diameter and pedicle entrance point differ from those in the white population. The results suggest that a 5-mm screw would be safer in the upper lumbar levels (L1, L2), and 6-mm screw in the lower lumbar levels (L3-L5). The pedicle entrance point migrates laterally for lower lumbar levels, especially at L5. The medial pedicle cortex can be safely sounded while the pedicle is probed.