Expression of e-cadherin with correlation to clinicopathologic parameters in oral squamous cell carcinoma

It becomes more concerned that the cell adhesion molecule plays an important role in the process of malignant transformation and tumor behaviors including invasive growth and metastasis. It is postulated if the expression of adhesion molecule is reduced in tumor tissue, the tumor cell will be undifferentiated and lose their cell adhesion ability and polarity. So the tumor cells lost the adhesion of cell to cell and to basement membrane that they became more aggressive. Reduced cadherin expression enhances invasiveness through infiltrative growth and metastasis of tumor cells is well known and mostly accepted in many epithelia tumors. We explored the expression of E-cadherin by immunohistochemical staining in 50 oral squamous cell carcinomas and investigated the correlation between the expression of E-cadherin and clinicopathologic parameters and prognosis. The expression of E-cadherin was reduced in 40/50(80%) of primary tumors, and 21/22(95.5%) of lymph nodes. The reduced expression of the E-cadherin was associated with lymph node metastasis(P=0.029), invasive mode(P=0.030) and marginal status(P=0.038). Survival analysis showed that predictive period of E-cadherin reduced group(37 months) was lower than that of E-cadherin preserved group(60 months), but there was no statistical significant difference.

Cemented Fixation Method of Glenoid Prosthesis in Total Shoulder Arthroplasty in a Pig Model / 대한정형외과학회잡지

PURPOSE: To observe the amount and distribution of overflown cement on the backsurface of the glenoid prosthesis and to determine the amount of cement required for ideal fixation of the glenoid prosthesis. MATERIALS AND METHODS: 48 keeled type glenoid prostheses (Global total shoulder, Depuy Co., U.S.A.) were fixed with four different volumes of cement (fully filled in the slots, and cement removed to depths of 4, 7 and 10 mm) to the scapulae of mature pigs, in which 46 scapulae that could be freed from the prostheses were investigated in terms of the amount and distribution of the leaked cement by gross inspection and evaluation using Arc view GIS 8.1. RESULTS: The cement overflowed in an irregular fashion. The average ratio of the area covered by leaked cement to glenoid surface was 30.7% (12.9-52.2) in 27 cases, in which the slots were completely filled by cement; 19% (13.4-29.9) in 6 cases in which a 4 mm depth of cement was removed from the slots; 1.8% (-7.5~16.8) in 8 cases in which a 7 mm depth of cement was removed from the slots; -10.2% (-15.8~-5.2) in 5 cases in which a 10 mm depth of cement was removed from the slots. CONCLUSION: It is impossible to prevent leakage of cement behind the backsurface of the glenoid prosthesis with the conventional cemented fixation method. This can be prevented by removing the equivalent amount of cement before inserting the prosthesis.

Analysis of 1,000 Cases of Total Knee Arthroplasty: Preliminary Report / 대한정형외과학회잡지

PURPOSE: To analyze the results and complications arising from 1,000 cases of primary total knee arthroplasty (TKRA), as performed by one surgeon. MATERIALS AND METHODS: From February, 1992 to June, 2000, 1,000 cases of primary TKRA were performed by a single surgeon. Among the 1,000 cases, 573 cases followed up for more than one year (average 2.9 years) were evaluated try allocating special surgery (HSS) scores and by determining the range of motion (ROM), and presence of complications retrospectively. RESULTS: There were 872 cases of primary osteoarthritis, 70 cases of rheumatoid arthritis, 32 cases of osteonecrosis, and 26 cases of miscellaneous diseases. The HSS score increased from 57.8 preoperatively to 90.4 postoperatively, ROM increased from 111degrees to 113degrees and flexion contracture decreased from 9degrees to 2degrees, but no statistical differences in results were observed between diseases. Common causes of complications were superficial infection (3.6%), deep infection (2.4%) and deep vein thrombosis (1.8%). Two patients died, one due to myocardial infarct and the other due to an unknown etiology. Revision arthroplasties were performed in 19 cases. CONCLUSION: After primary TKRA, ROM and functional score improved satisfactorily. No statistical differences were apparent between diseases. Infection was the most common complication.