1.
Org Biomol Chem
; 13(11): 3446-56, 2015 Mar 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25666467
RESUMO
A series of pentahydroxylated pyrrolidines, displaying five contiguous stereogenic centres and epimeric to α-glucosidase inhibitor homoDMDP, have been synthesized. The key step involves a γ-aminoalcohol rearrangement applied to polyhydroxylated azepanes. These five-membered iminosugars demonstrate micromolar inhibition of glycosidases.