Effect of neuroleptics on ethanol-treated rats.

The subject of the present study is the effect of neuroleptic anaesthetics on sleeping time and some biochemical parameters of ethanol-treated and untreated rats. In one set of experiments involving four groups of animals, we studied how ethanol (12%, v/v) consumption for 10, 20 and 30 days influenced the sleeping time of animals after administration of a single dose of the investigated anaesthetics. In the other set of experiments, we studied the combined effect of 30 day ethanol consumption and each of the anaesthetics administered to the animals in multiple doses for 3 h, by determining the contents of cytochrome P450 and glutathione and the activities of glutathione peroxidase and lipid peroxidation. The results show that statistically significant changes of measured parameters are due to the action of ethanol and not of the neuroleptic anaesthetics.

Effect of fentanyl, ketamine and thalamonal on some biochemical parameters in ethanol-treated and untreated dogs.

The effects of fentanyl, ketamine and thalamonal on some biochemical parameters of ethanol-treated and untreated dogs, were studied. The study was carried out on mongrel dogs. The animals were divided into two main groups: one which had free access to food and to 12% (v/v) ethanol, instead of water, and a control group which had food and water ad libitum. The animals in both groups were exposed to the action of anaesthetics for 3 h. The results show that, under the given experimental conditions, the anaesthetics did not significantly change the investigated parameters of blood and liver, either in ethanol-treated or untreated dogs. However, the action of ethanol caused remarkable changes in almost all the investigated parameters. An increased content of cytochrome P450 caused by the action of ethanol suggests possible changes in the metabolism of anaesthetics, which should be of concern to anaesthetists when dealing with patients potentially intoxicated with ethanol.