ELOVL2-AS1 suppresses tamoxifen resistance by sponging miR-1233-3p in breast cancer.

Tamoxifen (Tam) has long been a top treatment option for breast cancer patients, but the challenge of eliminating cancer recurrence remains. Here, we identify a signalling pathway involving ELOVL2, ELOVL2-AS1, and miR-1233-3p, which contributes to drug resistance in Tam-resistant (TamR) breast cancer. ELOVL2-AS1, a long noncoding RNA, was significantly upregulated by its antisense gene, ELOVL2, which is known to be downregulated in TamR cells. Additionally, ELOVL2-AS1 underwent the most hypermethylation in MCF-7/TamR cells. Furthermore, patients with breast cancer who developed TamR during chemotherapy had significantly lower expression of ELOVL2-AS1 compared to those who responded to Tam. Ectopic downregulation of ELOVL2-AS1 by siRNA both stimulated cancer cell growth and deteriorated TamR. We also found that ELOVL2-AS1 sponges miR-1233-3p, which has pro-proliferative activity and elevates TamR, leading to the activation of potential target genes, such as MYEF2, NDST1, and PIK3R1. These findings suggest that ELOVL2-AS1, in association with ELOVL2, may contribute to the suppression of drug resistance by sponging miR-1233-3p in breast cancer.

A Hierarchically Tailored Wrinkled Three-Dimensional Foam for Enhanced Elastic Supercapacitor Electrodes.

Recently, three-dimensional (3D) porous foams have been studied, but further improvement in nanoscale surface area and stretchability is required for electronic and energy applications. Herein, a general strategy is reported to form a tailored wrinkling structure on strut surfaces inside a 3D polydimethylsiloxane (PDMS) polymeric foam. Controlled wrinkles are created on the struts of 3D foam through an oxygen plasma treatment to form a bilayer surface of PDMS on uniaxially prestretched 3D PDMS foam, followed by relaxation. After plasma treatment for 1 h and prestretching of 40%, the wrinkled 3D foam greatly improves specific surface area and stretchability by over 60% and 75%, respectively, compared with the pristine 3D PDMS foam. To prove its applicability with improved performances, supercapacitors are prepared by coating a conductive material on the wrinkled 3D foam. The resulting supercapacitors exhibit an increased storage capacity (8.3 times larger), maintaining storage capacity well under stretching up to 50%.

Bioinspired Microsphere-Embedded Adhesive Architectures for an Electrothermally Actuating Transport Device of Dry/Wet Pliable Surfaces.

For highly conformable and universal transport devices, bioinspired dry adhesion systems with reversible molecular attractions (e.g., van der Waals forces, capillarity, or suction stress) between the engaged surfaces have recently become favorable for various dry/wet processes in flexible devices and medical applications. In addition, many efforts have been made for switchable attachments of such adhesives by employing costly sophisticated systems such as mechanically deformable chucks, UV-radiating components, or fluidic channels. In this work, we propose a simple electrothermally actuating transport device based on an octopus-inspired microsphere-embedded sucker (OMS). The adhesive with microsphere-embedded suckers offers enhanced adhesion on dry/wet surfaces, in accordance with investigation of the geometric and materials parameters of the novel suction architecture for maximizing adhesion interactions. Inspired by muscle actuation of octopus tentacles, we laminate the electrothermally reactive poly(3,4-ethylenedioxy thiophene):poly(styrenesulfonic acid) (PEDOT:PSS) layer on the backside of the OMS adhesive patch. By controlling inputs of electrical energy, our assembled actuator may actively expand and contract reversibly to induce switchable attachments and detachments. Our bioinspired device can be integrated onto a robotic arm to attach and release against dry/wet flexible thin objects.

Highly Air/Water-Permeable Hierarchical Mesh Architectures for Stretchable Underwater Electronic Skin Patches.

The development of an electronic skin patch that can be used in underwater environments can be considered essential for fabricating long-term wearable devices and biomedical applications. Herein, we report a stretchable conductive polymer composite (CPC) patch on which an octopus sucker-inspired structure is formed to conformally contact with biological skin that may be rough and wet. The patch is patterned with a hexagonal mesh structure for water and air permeability. The patch films are suited for a strain sensor or a stretchable electrode as their piezoresistive responses can be controlled by changing the concentration of conductive fillers to polymeric polyurethane. The CPC patch with a hexagonal mesh pattern (HMP) can be easily stretched for a strain sensor and is insensitive to tensile strain, making the patch suitable as a stretchable electrode. Furthermore, the octopus-like structures formed on the skeleton of the HMP allow the patch to maintain strong adhesion underwater by easily draining excess water trapped between the patch and skin. The sensor patch (<50 wt % carbon nanotubes (CNTs)) can sensitively detect the bending strain of a finger, and the electrode patch (50 wt % CNTs with addition of Ag flakes) can stably measure biosignals (e.g., electrocardiogram signals) under both dry and wet conditions owing to the octopus-like structure and HMP.

Carbon-Based, Ultraelastic, Hierarchically Coated Fiber Strain Sensors with Crack-Controllable Beads.

Fiber-based electronics or textronics are spotlighted as a promising strategy to develop stretchable and wearable devices for conformable machine-human interface and ubiquitous healthcare systems. We have prepared a highly sensitive fiber-type strain sensor (maximum gauge factor (GF) = 863) with a broad range of strain (ε < 400%) by introducing a single active layer onto the fiber. In contrast to other metal-based fiber-type electronics, our hierarchical fiber sensors are based on coating carbon-based nanomaterials with responsive microbeads onto elastic fibers. Utilizing the formation of uniform cracks around the microbeads, the device performance was maximized by adjusting the number of microbeads in the carbon-coating layer. We overcoated the carbon-based coating layer of the elastic fiber with a protective polymeric layer and verified no effects on the GF and the range of strain. Our fiber sensors were repeatedly tested more than 5000 times, exhibiting excellent cyclic responses to on/off switching behaviors. For practical applications, the hierarchical fiber sensors were sewed into electrical fabric bands, which are integrable to a wireless transmitter to monitor waveforms of pulsations, respirations, and various postures of level of bending a spinal cord.