[Relation of surgical results and proposed skull base meningioma grading system: analysis of clinical series with 42 patients].

UNLABELLED: Anatomical localisation of skull base meningioma link, their growth and relations with neurovascular structures reduce possibility for radical operation, and offten request additional preoperative or postoperative radiotherapy. We compared personal results of extent surgical resection and skull base meningioma treating outcome with predispose factors scale for surgical radicality and postoperative outcome. We present 42 patients, who were operated in Institute of neurosurgery CCS during the period from 2004 to 2006. RESULTS: Radical resection was possible in 29 cases, and in 13 cases reduction of tumor mass has been performed. Statistical significant predispose factor for radical resection were: absance of preoperative radiotherapy, intact functions of n.III, n.VI, tumor borders inside one skull base fossa and outside of magistral blood vessels. Karnofsky index at the end of following period statistical significant higher in patients with radical resection of skull base meningeioma. Preoperative radiological finding is singificant guide in planning of therapeutic protocol for skull base meningioma. Growth of tumor and relation with neurovascular structures restrict extent of resection and often request additional postoperative radiotherapy or reoperation.

Risk factors from brain tumors in children and adolescents: a case-control study in Belgrade, Serbia.

The objective of the present study was to test the different hypotheses about factors related to the occurrence of brain tumors in children and adolescents. The case-control study of brain tumors was conducted in Belgrade (Serbia) from 1998 through 2000. The study group consisted of 60 newly diagnosed brain tumor patients and the same number of hospital controls. In the analysis conditional univariate and multivariate logistic regression were applied. According to the final model of multivariate analysis the following factors were significantly related to brain tumors: schooling of father <14 years (OR = 11.05, 95% CI 2.41-50.63, P = 0.002), mothers - housewives or workers versus clerks (OR = 2.62, 95% CI 1.06-6.57, P = 0.036), number of brothers and sisters greater than one (OR = 3.02, 95% CI 1.50-7.22, P = 0.001), and more frequent presence of malignant diseases, including brain tumors, in family history (OR = 3.54, 95% CI 1.30-9.60, P = 0.001). This case-control study was made to investigate different factors of possible importance for brain tumors in children and adolescents. Lower family social status, and more frequent occurrence of malignant tumors amongst relatives seem to be the factors that contribute the most to the higher risk of brain tumors.

The electrocorticographic status and the extent of the cortical resection in epileptic patients.

In three patients operated on for focal epilepsy small pathological lesions in the functionally important cortical regions were microsurgically extirpated. The neighbouring areas of cortex were preseved, although they showed epileptic activity on electrocorticography. The patients are seizure-free three years, two years, and nineteen months later, respectively. On the bases of these facts and experience with another 35 patients operated on for focal epilepsy the authors speculate on the relations between the pathological lesion, epileptogenic cortical area, and the relative dependence of the extent of cortical resection on the electrocorticographic status.