Bulk dentine replacement versus incrementally placed resin composite: A randomised controlled clinical trial.

OBJECTIVE: This randomized controlled clinical trial compared two techniques and materials for restoring carious teeth-Bulk dentine replacement versus incremental placement of a hybrid posterior resin composite material in terms of patient comfort (post operative sensitivity and tenderness on biting). MATERIAL AND METHODS: Seventy-two carious teeth were randomized to one of two treatment groups: Group A-were restored with a bulk dentine replacement material or Group B-restored with incrementally placed hybrid composite. Patients were followed up by way of a structured phone call at day 2 and day 7 post-operatively. Patients reporting discomfort at day 7 were subsequently followed up on days 14, and 30. RESULTS: All patients were followed up. At day 2, 18/72 restored teeth had post-operative sensitivity; this figure fell to 10/72 at day 7. A Chi squared test revealed that at day 2 a greater level of sensitivity was reported by patients in Group A (P=0.029). However, at day 7 there was no statistically significant difference between the two groups in terms of sensitivity (P=0.453). 8/72 and 6 /72 teeth had tenderness to biting at days 2 and 7 respectively. A Chi squared test revealed no statistically significant difference between the two groups in terms of tenderness on biting at any time period (P=0.722). Interestingly, Class I cavities were found to be more tender on biting than Class II cavities. At day 30 2/72 teeth exhibited sensitivity and none of the teeth exhibiting tenderness on biting. CONCLUSION: At day 7 there was no significant difference between the two groups in terms of postoperative sensitivity and tenderness on biting.

Bilineal transmission in Tourette syndrome.

OBJECTIVE: To investigate the frequency and pattern of bilineal transmission in families of patients with Tourette syndrome (TS) compared with normal control subjects. METHODS: The study population consisted of two groups: 1) consecutive patients with TS with both parents (51 family sets; 153 individuals), and 2) normal control subjects randomly selected from public schools (20 family sets; 60 individuals). All patients with TS, normal control subjects, and their parents were evaluated for evidence of TS and associated features. Structured interviews and detailed questionnaires designed to assess tics, obsessive-compulsive behavior (OCB), and attention deficit disorder (ADD) were administered to all people in both groups. RESULTS: In addition to tics, 43 (84.3%) patients with TS had ADD, 33 (64.7%) had OCB, and 31 (60.8%) had both ADD and OCB. In 42 (82.4%) of the 51 patients, at least one parent exhibited features of TS; unilineal transmission (only one parent with tics, OCB, or ADD) was present in 29 (56.9%) TS families and an additional 13 (25.5%) TS families manifested evidence of bilineal transmission (both parents affected). More fathers than mothers of patients with TS had tics (31.4% versus 15.7%), whereas more mothers had OCB than did fathers (33.3% versus 15.7%). Features of ADD were equally distributed among fathers (35.3%) and mothers (33.3%) of patients with TS. Eight of 1,142 (0.7%) children in the general school population had some evidence of TS. One of 40 parents of the normal control subjects (2.5%) had symptoms of ADD, but none of the parents of normal control subjects manifested any features of TS or OCB. CONCLUSIONS: This study found evidence for bilineal transmission in one fourth of TS families. Features of the TS spectrum were rare in normal control families. Evidence of tics, OCB, and ADD should be investigated in both parents of patients with TS.