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1.
Clin Otolaryngol ; 48(4): 563-575, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37118939

RESUMO

OBJECTIVES: Needle electromyography (EMG) may be used to characterise the severity of the injury in acute peripheral facial nerve palsy (FNP) to predict recovery and guide management, but its prognostic value and clinical utility remain controversial. The aim of this systematic review was to evaluate the role of EMG to prognosticate the recovery of facial motor function in patients with acute peripheral FNP. DESIGN: A comprehensive search strategy was applied in PubMed, Embase, and Web of Science based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The main outcome measure was the accuracy of EMG in predicting long-term facial function at least 6 months following symptom onset. RESULTS: Eleven studies were included comprising 3837 participants, with 91.6% of these diagnosed with Bell's palsy (BP). In BP patients, the positive predictive value and negative predictive value for a good outcome based on EMG findings ranged from 82.1% to 100% and 66.7% to 80.5%, respectively, with two out of three studies finding that EMG remained a significant predictor of the outcome on multivariate analysis. Three studies addressed the role of EMG in non-idiopathic FNP with two of these studies supporting EMG to predict prognosis. CONCLUSIONS: EMG is a useful tool to gain insight into the likely outcome to guide management decisions and counsel patients on their expectations, particularly in BP. However, given inconsistencies in its application and lack of evidence around non-idiopathic FNP, it should not currently be relied on to predict recovery. Ultimately, its prognostic value and widespread adoption are dependent on the implementation of a clear and standardised protocol in future high-quality studies and routine clinical settings.


Assuntos
Paralisia de Bell , Paralisia Facial , Humanos , Eletromiografia/métodos , Nervo Facial , Paralisia Facial/diagnóstico , Paralisia de Bell/diagnóstico , Face
5.
J Multidiscip Healthc ; 8: 139-46, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25834455

RESUMO

BACKGROUND: The Theoretical Domains Framework (TDF) is an integrative framework developed from a synthesis of psychological theories as a vehicle to help apply theoretical approaches to interventions aimed at behavior change. PURPOSE: This study explores experiences of TDF use by professionals from multiple disciplines across diverse clinical settings. METHODS: Mixed methods were used to examine experiences, attitudes, and perspectives of health professionals in using the TDF in health care implementation projects. Individual interviews were conducted with ten health care professionals from six disciplines who used the TDF in implementation projects. Deductive content and thematic analysis were used. RESULTS: Three main themes and associated subthemes were identified including: 1) reasons for use of the TDF (increased confidence, broader perspective, and theoretical underpinnings); 2) challenges using the TDF (time and resources, operationalization of the TDF) and; 3) future use of the TDF. CONCLUSION: The TDF provided a useful, flexible framework for a diverse group of health professionals working across different clinical settings for the assessment of barriers and targeting resources to influence behavior change for implementation projects. The development of practical tools and training or support is likely to aid the utility of TDF.

6.
Neuropsychiatr Dis Treat ; 9: 1371-80, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24072972

RESUMO

Tardive dyskinesia (TDK) includes orobuccolingual movements and "piano-playing" movements of the limbs. It is a movement disorder of delayed onset that can occur in the setting of neuroleptic treatment as well as in other diseases and following treatment with other drugs. The specific pathophysiology resulting in TDK is still not completely understood but possible mechanisms include postsynaptic dopamine receptor hypersensitivity, abnormalities of striatal gamma-aminobutyric acid (GABA) neurons, and degeneration of striatal cholinergic interneurons. More recently, the theory of synaptic plasticity has been proposed. Considering these proposed mechanisms of disease, therapeutic interventions have attempted to manipulate dopamine, GABA, acetylcholine, norepinephrine and serotonin pathways and receptors. The data for the effectiveness of each class of drugs and the side effects were considered in turn.

7.
Drug Alcohol Rev ; 32(3): 333-4, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23419101

RESUMO

Amyl nitrite 'poppers' are recreational drugs, which are a potent source of nitric oxide. The use of 'poppers' can cause psychoactive stimulation, reduced blood pressure, tachycardia and involuntary muscle relaxation. Their use is becoming increasingly common around the world, including approximately 60% of Australia's male homosexual community. We report the first case of 'popper'-induced vision loss in Australasia.


Assuntos
Nitrito de Amila/efeitos adversos , Cegueira/induzido quimicamente , Cegueira/diagnóstico , Drogas Ilícitas/efeitos adversos , Adulto , Humanos , Masculino
8.
J Neurol Neurosurg Psychiatry ; 84(7): 806-12, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23418209

RESUMO

OBJECTIVE: Hereditary liability to pressure palsies (HNPP) is an autosomal dominant disorder of myelination resulting in susceptibility to pressure palsies from compression or stretching of peripheral nerves. PATIENTS AND METHODS: This study examined axonal excitability at two sites (one distal and one proximal) in five patients with biopsy and genetically proven HNPP to understand the pathophysiology of the disease. Comparisons were made with age-matched control subjects as well as five Charcot-Marie-Tooth type 1A patients to contrast the findings and explain the different phenotypes of diseases affecting the same gene. RESULTS: Changes in axonal excitability were found in HNPP subjects, but these were not uniform along the nerve: at the wrist there were prominent alterations in threshold electrotonus, whereas at the elbow there were only subtle alterations in the recovery cycle and the response to strong long-lasting hyperpolarisation. Threshold was raised at both sites, but the nerves were probably not hyperpolarised. Not unexpectedly, changes in CMT1A subjects were more marked than those in HNPP subjects and were uniform along the nerve. CONCLUSIONS: Structural abnormalities at the node of Ranvier are sufficient to explain the changes in axonal excitability in HNPP, and these abnormalities would predispose the nerves to conduction block when subjected to pressure or stretch.


Assuntos
Artrogripose/genética , Artrogripose/fisiopatologia , Axônios , Neuropatia Hereditária Motora e Sensorial/genética , Neuropatia Hereditária Motora e Sensorial/fisiopatologia , Adulto , Biópsia , Plexo Braquial/lesões , Doença de Charcot-Marie-Tooth/genética , Doença de Charcot-Marie-Tooth/fisiopatologia , Interpretação Estatística de Dados , Doenças Desmielinizantes/patologia , Cotovelo/inervação , Estimulação Elétrica , Feminino , Humanos , Estudos Longitudinais , Masculino , Nervo Mediano/fisiopatologia , Pessoa de Meia-Idade , Modelos Estatísticos , Neurônios Motores , Tono Muscular , Bainha de Mielina/patologia , Canais de Potássio/metabolismo , Pressão , Reprodutibilidade dos Testes , Nervo Sural/patologia , Punho/inervação
9.
Muscle Nerve ; 45(1): 43-7, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22190305

RESUMO

BACKGROUND: Axonal excitability is altered in common medical conditions such as stroke, multiple sclerosis, and spinal cord injury. Given the motor neuron changes in the presence of rigidity and tremor in Parkinson disease, we examine whether there are also changes in motor axon excitability. METHODS: Axonal excitability studies were performed in 15 Parkinson subjects and 12 age-matched control subjects. RESULTS: There was no significant difference in excitability indices between Parkinson subjects and control subjects. CONCLUSIONS: It is unlikely that the lack of change in the excitability indices reflects a balance between the effects of bradykinesia ("underactivity") and the effects of rigidity and tremor ("overactivity") on the motoneuron and its axon. It is more likely that plastic changes in motoneuron properties do not occur symmetrically with decreases and increases in activity, being more profound when activity levels are interrupted and less obvious when they are enhanced.


Assuntos
Neurônios Motores/fisiologia , Músculo Esquelético/patologia , Doença de Parkinson/patologia , Doença de Parkinson/fisiopatologia , Potenciais de Ação/fisiologia , Idoso , Idoso de 80 Anos ou mais , Biofísica , Estudos de Casos e Controles , Estimulação Elétrica/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Força Muscular/fisiologia , Músculo Esquelético/fisiopatologia , Índice de Gravidade de Doença
12.
J Clin Neurosci ; 16(12): 1639-41, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19766007

RESUMO

This report documents changes to axonal excitability in motor nerves in acute camphor toxicity. Although there were no changes to indicate an alteration in resting membrane potential, there was an exaggerated response to hyperpolarising currents in both threshold electrotonus and the current-threshold relationship. These findings suggest a transient decrease in the hyperpolarisation-activated conductance (I(H)). This report demonstrates that recently developed techniques for measuring axonal excitability are readily applied in the acute care setting and can document subclinical abnormalities that could be relevant to the underlying pathophysiology.


Assuntos
Axônios/fisiologia , Cânfora/intoxicação , Síndromes Neurotóxicas/patologia , Adulto , Axônios/efeitos dos fármacos , Cânfora/farmacologia , Feminino , Humanos , Potenciais da Membrana/efeitos dos fármacos , Potenciais da Membrana/fisiologia , Condução Nervosa/efeitos dos fármacos , Síndromes Neurotóxicas/etiologia , Síndromes Neurotóxicas/fisiopatologia , Tempo de Reação/efeitos dos fármacos , Limiar Sensorial
14.
J Physiol ; 587(2): 491-504, 2009 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-19047204

RESUMO

The present study explores the threshold behaviour of human axons and the mechanisms contributing to this behaviour. The changes in excitability of cutaneous afferents in the median nerve at the wrist were recorded to a long-lasting subthreshold conditioning stimulus, with a waveform designed to maximize the contribution of currents active in the just-subthreshold region. The conditioning stimulus produced a decrease in threshold that developed over 3-5 ms following the end of the depolarization and then decayed slowly, in a pattern similar to the recovery of axonal excitability following a discharge. To ensure that the conditioning stimulus did not activate low-threshold axons, similar recordings were then made from single motor axons in the ulnar nerve at the elbow. The findings were comparable, and behaviour with the same pattern and time course could be reproduced by subthreshold stimuli in a model of the human axon. In motor axons, subthreshold depolarizing stimuli, 1 ms long, produced a similar increase in excitability, but the late hyperpolarizing deflection was less prominent. This behaviour was again reproduced by the model axon and could be explained by the passive properties of the nodal membrane and conventional Na+ and K+ currents. The modelling studies emphasized the importance of leak current through the Barrett-Barrett resistance, even in the subthreshold region, and suggested a significant contribution of K+ currents to the threshold behaviour of axons. While the gating of slow K+ channels is slow, the resultant current may not be slow if there are substantial changes in membrane potential. By extrapolation, we suggest that, when human axons discharge, nodal slow K+ currents will be activated sufficiently early to contribute to the early changes in excitability following the action potential.


Assuntos
Axônios/fisiologia , Modelos Neurológicos , Nervo Ulnar/fisiologia , Potenciais de Ação/fisiologia , Adulto , Estimulação Elétrica , Feminino , Humanos , Ativação do Canal Iônico/fisiologia , Masculino , Nervo Mediano/fisiologia , Potenciais da Membrana/fisiologia , Pessoa de Meia-Idade , Neurônios Motores/fisiologia , Neurônios Aferentes/fisiologia , Canais de Potássio/fisiologia , Células Receptoras Sensoriais/fisiologia , Limiar Sensorial , Canais de Sódio/fisiologia
15.
J Neurophysiol ; 100(6): 3275-84, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18922951

RESUMO

The interpretation of changes in the soleus H reflex is problematic in the face of reflex gain changes, a nonlinear input/output relationship for the motoneuron pool, and a nonhomogeneous response of different motoneurons to afferent inputs. By altering the stimulus intensity to maintain a constant reflex output, threshold tracking allows a relatively constant population of alpha-motoneurons to be studied. This approach was used to examine postactivation ("homosynaptic") depression of the H reflex (HD) in 23 neurologically healthy subjects. The H reflex was elicited by tibial nerve stimulation at 0.05, 0.1, 0.3, 1, and 2 Hz at rest and during voluntary plantar flexion at 2.5, 5, and 10% of maximum. A computerized threshold tracking procedure was used to set the current needed to generate a target H reflex 10% of M(max). The current needed to produce the target reflex increased with stimulus rate but not significantly beyond 1 Hz. In three subjects, the current needed to produce H reflexes of 5, 10, 15, and 20% M(max) at 0.3, 1, and 2 Hz increased with rate and with the size of the test H reflex. HD was significantly reduced during voluntary contractions. Using threshold tracking, HD was maximal at lower frequencies than previously emphasized, probably because HD is greater the larger the test H reflex. This would reinforce the greater sensitivity of small motoneurons to reflex inputs.


Assuntos
Adaptação Fisiológica/fisiologia , Reflexo H/fisiologia , Músculo Esquelético/fisiologia , Inibição Neural/fisiologia , Limiar Sensorial/fisiologia , Adulto , Biofísica , Estimulação Elétrica/métodos , Eletromiografia/métodos , Potencial Evocado Motor , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Contração Muscular/fisiologia , Adulto Jovem
16.
J Physiol ; 581(Pt 3): 927-40, 2007 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-17363389

RESUMO

This study investigated whether there are changes in the excitability of motor axons in peripheral nerves of patients with corticospinal lesions, reflecting plasticity of the motoneuron due to altered descending drives and/or changes in afferent feedback. The excitability of motor and sensory axons in peripheral nerves of the affected limb of 11 patients with unilateral hemiparesis due to stroke was compared with that for the unaffected limbs and with data for 12 age-matched controls. There was significantly less accommodation to hyperpolarizing currents in motor axons on the affected side. There were small differences between the data for the unaffected side and that of the control subjects but these were not statistically significant. Other findings indicate that there was no change in resting membrane potential. There was no comparable alteration in the excitability of sensory axons. The changes in response of motor axons to hyperpolarizing currents could be reproduced in a computer model of the human motor axon by reducing the hyperpolarization-activated conductance, IH, by 30% and the quantitatively small leak conductance by 77%. The data for the uninvolved side matched the data for control subjects best when IH was increased. These findings are consistent with modulation of IH by activity. They demonstrate a change in the biophysical properties of motor axons not directly affected by the pathology and synaptically remote from the lesion, and have implications for 'trans-synaptic' changes in central nervous system pathways. In human subjects studies of motor axon properties may allow insight into processes affecting the motoneuron.


Assuntos
Nervo Mediano/fisiopatologia , Condução Nervosa , Plasticidade Neuronal , Tratos Piramidais/fisiopatologia , Traumatismos da Medula Espinal/fisiopatologia , Acidente Vascular Cerebral/complicações , Potenciais de Ação , Adulto , Idoso , Axônios/patologia , Isquemia Encefálica/complicações , Isquemia Encefálica/fisiopatologia , Estudos de Casos e Controles , Simulação por Computador , Estimulação Elétrica , Feminino , Humanos , Masculino , Nervo Mediano/patologia , Pessoa de Meia-Idade , Modelos Neurológicos , Neurônios Motores/patologia , Contração Muscular , Músculo Esquelético/inervação , Músculo Esquelético/fisiopatologia , Neurônios Aferentes/patologia , Tratos Piramidais/patologia , Tempo de Reação , Índice de Gravidade de Doença , Traumatismos da Medula Espinal/etiologia , Traumatismos da Medula Espinal/patologia , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/fisiopatologia , Punho
17.
Muscle Nerve ; 33(3): 384-92, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16435342

RESUMO

We investigated the influence of the history of activity on the contractile properties of abductor pollicis brevis (APB) to define how the forces produced by individual stimuli change within a stimulus train, with a view to clarifying the optimal discharge frequency for force production in brief trains. Supramaximal electrical stimuli were delivered to the median nerve at the wrist singly or in trains of 2-5 at various interstimulus intervals (ISIs). The force and electromyographic (EMG) responses to trains of n stimuli were defined by online subtraction of the responses to n - 1 stimuli. The force attributable to the nth stimulus was normalized to that produced by a single stimulus. The contraction force produced by 2 stimuli exceeded the force expected with linear summation of 2 single twitches by 30-40% at ISIs of 2-100 ms. Increasing the number of stimuli resulted in less augmentation of the force produced by the last stimulus in the train for ISIs up to 20 ms, but greater augmentation for ISIs of 50-100 ms. At ISIs of less than 10 ms, the time to peak force produced by the last stimulus in a 5-pulse train was delayed by approximately 100 ms, the peak force produced by that stimulus was less than that produced by a single stimulus, and it occurred on the falling phase of the overall contraction. These properties are best explained by the catchlike property of muscle. This implies that the augmentation of contraction force due to this property can increase throughout a stimulus train, and is not restricted to the doublet discharges that have conventionally been studied. We conclude that, with brief discharge trains, maximal forces occur at ISIs of 56-75 ms, intervals that are longer than those conventionally associated with the catchlike property. Discharge rates of 15-20 HZ appear to be optimal for force generation by APB during steady contractions.


Assuntos
Músculo Esquelético/patologia , Adulto , Estimulação Elétrica , Eletromiografia , Eletrofisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Contração Muscular/fisiologia , Punho/inervação , Punho/fisiologia
18.
J Physiol ; 564(Pt 3): 931-40, 2005 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-15746167

RESUMO

Subthreshold electrical stimuli can generate a long-lasting increase in axonal excitability, superficially resembling the phase of superexcitability that follows a conditioning nerve impulse. This phenomenon of 'subthreshold superexcitability' has been investigated in single motor axons in six healthy human subjects, by tracking the excitability changes produced by conditioning stimuli of different amplitudes and waveforms. Near-threshold 1 ms stimuli caused a mean decrease in threshold at 5 ms of 22.1 +/- 6.0% (mean +/-s.d.) if excitation occurred, or 6.9 +/- 2.6% if excitation did not occur. The subthreshold superexcitability was maximal at an interval of about 5 ms, and fell to zero at 30 ms. It appeared to be made up of two components: a passive component linearly related to conditioning stimulus amplitude, and a non-linear active component. The active component appeared when conditioning stimuli exceeded 60% of threshold, and accounted for a maximal threshold decrease of 2.6 +/- 1.3%. The passive component was directly proportional to stimulus charge, when conditioning stimulus duration was varied between 0.2 and 2 ms, and could be eliminated by using triphasic stimuli with zero net charge. This change in stimulus waveform had little effect on the active component of subthreshold superexcitability or on the 'suprathreshold superexcitability' that followed excitation. It is concluded that subthreshold superexcitability in human motor axons is mainly due to the passive electrotonic effects of the stimulating current, but this is supplemented by an active component (about 12% of suprathreshold superexcitability), due to a local response of voltage-dependent sodium channels.


Assuntos
Potenciais de Ação/fisiologia , Axônios/fisiologia , Limiar Diferencial/fisiologia , Estimulação Elétrica/métodos , Neurônios Motores/fisiologia , Plasticidade Neuronal/fisiologia , Adaptação Fisiológica/fisiologia , Humanos
19.
Muscle Nerve ; 30(4): 437-43, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15372538

RESUMO

The present study addressed whether the excitability of motor axons could be documented by tracking a target submaximal contraction force rather than a target submaximal compound muscle action potential (CMAP). In 10 subjects, multiple excitability measures were recorded using the Trond protocol, tracking twitch contraction force and the CMAP in response to stimulation of the median nerve at the wrist and twitch force to stimulation at the motor point. With stimulation at the wrist, the findings were virtually identical with force tracking and CMAP tracking for indices dependent on unconditioned thresholds (stimulus-response curves; strength-duration properties) and when the conditioning stimulus was subthreshold (threshold electrotonus; current-threshold relationship). However, when the conditioning stimulus was supramaximal, as in recovery cycle studies, thresholds for the target force were lower in all subjects than for the target CMAP. There was variability between different subjects in the extent of this offset. However, force tracking can still be used to follow changes in refractoriness and supernormality when membrane potential changes during an experiment. The excitability indices differed with motor point stimulation, but it is argued that this could be due to the geographic dispersion of motor axons at the motor point in addition to or instead of differences in biophysical properties of the stimulated nodes. Thus, tracking twitch contraction force is a potentially valuable alternative to tracking the CMAP, but is more complicated and the results need to be interpreted with caution.


Assuntos
Axônios/fisiologia , Músculo Esquelético/fisiologia , Potenciais de Ação/fisiologia , Adulto , Fenômenos Biofísicos , Biofísica , Estimulação Elétrica , Feminino , Antebraço/inervação , Antebraço/fisiologia , Humanos , Contração Isométrica/fisiologia , Masculino , Potenciais da Membrana/fisiologia , Pessoa de Meia-Idade , Contração Muscular/fisiologia , Músculo Esquelético/inervação , Período Refratário Eletrofisiológico/fisiologia
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