RESUMO
The qualitative and quantitative effects of the (+)-S and (-)-R enantiomers and of the racemic mixture of the Ca2+ channel antagonist, nicardipine, were compared on the isolated porcine coronary artery with intact and removed endothelium. All three forms of nicardipine inhibited the contractions induced by KCl (5-90 mM) in both vessel preparations. The potency (IC50) of the (+)-S and (-)-R enantiomers and of the racemic mixture was 6.6, 31.8 and 10.9 nM in the vessel with endothelium and 6.4, 41.9 and 9.8 nM in the vessel without endothelium. The parameters of the concentration-response curves for each form of nicardipine at a submaximal KCl (60 mM) concentration and the potency ratios between the two enantiomers ((+)-S/(-)-R) were not statistically significantly different (P>0.05) in the two vessel preparations. In conclusion, qualitatively, all three forms of nicardipine showed only Ca2+ channel antagonistic effects in both vessel preparations. Quantitatively, the inhibition of contraction was stereoselective, the (+)-S enantiomer being the most potent, and was endothelium-independent.
Assuntos
Bloqueadores dos Canais de Cálcio/farmacologia , Endotélio Vascular/fisiologia , Nicardipino/farmacologia , Animais , Vasos Coronários/efeitos dos fármacos , Vasos Coronários/fisiologia , Relação Dose-Resposta a Droga , Técnicas In Vitro , Contração Muscular/efeitos dos fármacos , Nicardipino/química , Cloreto de Potássio/farmacologia , Estereoisomerismo , Suínos , Vasoconstrição/efeitos dos fármacosRESUMO
The value of ultrasound (US) is analysed by means of ROC-curves (receiver operating curves) taking into consideration both the sensitivity and specificity of the method, as well as the prevalence of particular tumours in the examined group. US diagnosis is compared with clinical and surgical findings. The authors have found that the degree of reliability achieved by either the clinical or the US method of diagnosing myomas is almost the same. In the diagnosis of benign cysts and carcinomas, however, US has more advantages.
Assuntos
Neoplasias dos Genitais Femininos/diagnóstico , Ultrassonografia , Carcinoma/diagnóstico , Cistos/diagnóstico , Diagnóstico Diferencial , Feminino , Doenças dos Genitais Femininos/diagnóstico , Humanos , Mioma/diagnósticoRESUMO
For tocolysis in pregnancy and labour the authors have used Dilatol (Bufenin) since 1970 and Partusisten since 1976. In 1977 tocolysis was applied in 354 pregnant women (10.6%) : 63 (17.8%) were give tocolytics for premature pain, 18 (5.1%) for the premature rupture of the fetal membranes, and 273 (77.1%) for prophylactic reasons, mostly following cerclage and in cases of multiple pregnancy. In the therapeutic use of tocolysis in 63 women, pain disappeared in 46 of them and they continued to be treated in the out-patient unit; 17 women continued being treated with tocolytics until the beginning of premature labour.20
