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BACKGROUND AND OBJECTIVE: The coronavirus disease 2019 Living OVerview of Evidence (COVID-19 L·OVE) is a public repository and classification platform for COVID-19 articles. The repository contains more than 430,000 articles as of September 20, 2021 and intends to provide a one-stop shop for COVID-19 evidence. Considering that systematic reviews conduct high-quality searches, this study assesses the comprehensiveness and currency of the repository against the total number of studies in a representative sample of COVID-19 systematic reviews. METHODS: Our sample was generated from all the studies included in the systematic reviews of COVID-19 published during April 2021. We estimated the comprehensiveness of COVID-19 L·OVE repository by determining how many of the individual studies in the sample were included in the COVID-19 L·OVE repository. We estimated the currency as the percentage of studies that was available in the COVID-19 L·OVE repository at the time the systematic reviews conducted their own search. RESULTS: We identified 83 eligible systematic reviews that included 2,132 studies. COVID-19 L·OVE had an overall comprehensiveness of 99.67% (2,125/2,132). The overall currency of the repository, that is, the proportion of articles that would have been obtained if the search of the reviews was conducted in COVID-19 L·OVE instead of searching the original sources, was 96.48% (2,057/2,132). Both the comprehensiveness and the currency were 100% for randomized trials (82/82). CONCLUSION: The COVID-19 L·OVE repository is highly comprehensive and current. Using this repository instead of traditional manual searches in multiple databases can save a great amount of work to people conducting systematic reviews and would improve the comprehensiveness and timeliness of evidence syntheses. This tool is particularly important for supporting living evidence synthesis processes.
Assuntos
COVID-19 , Humanos , COVID-19/epidemiologia , PublicaçõesRESUMO
The solvothermal synthesis of metal-organic frameworks (MOFs) often proceeds through competing crystallization pathways, and only partial control over the crystal nucleation and growth rates is possible. It challenges the use of MOFs as functional devices in free-space optics, where bulk single crystals of millimeter dimensions and high optical quality are needed. We develop a synthetic protocol to control the solvothermal growth of the MOF [Zn(3-ptz)2] n (MIRO-101), to obtain large single crystals with projected surface areas of up to 25 mm2 in 24 h, in a single reaction with in situ ligand formation. No additional cooling and growth steps are necessary. We propose a viable reaction mechanism for the formation of MIRO-101 crystals under acidic conditions, by isolating intermediate crystal structures that directly connect with the target MOF and reversibly interconverting between them. We also study the nucleation and growth kinetics of MIRO-101 using ex situ crystal image analysis. The synthesis parameters that control the size and morphology of our target MOF crystal are discussed. Our work deepens our understanding of MOF growth processes in solution and demonstrates the possibility of building MOF-based devices for future applications in optics.
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El soporte tecnológico a través de equipos y aplicaciones médicas especializadas se ha convertido en una necesidad en el área de la neurocirugía. Frecuentemente, el neurocirujano utiliza sistemas asistidos por computador y neuronavegadores como herramientas auxiliares durante las fases pre-operatoria e intra-operatoria de la cirugía. Estas herramientas tecnológicas permiten planificar el abordaje quirúrgico de una forma rápida, eficiente e interactiva, facilitando también el uso de técnicas quirúrgicas de mínima invasión, como la cirugía estereotáxica. En este trabajo se presenta la utilización del software para neuronavegación que desarrollamos, en la planificación pre-operatoria de una intervención con marco estereotáxico para remover una lesión de aracnoidocele. El software soporta el manejo de imágenes e información conforme con el estándar DICOM, la visualización directa de datos volumétricos con mapeo de texturas 2D y 3D, el despliegue de imágenes multimodales y la segmentación de estructuras anatómicas, permitiendo al neurocirujano definir la trayectoria y el protocolo del abordaje quirúrgico mientras efectúa la navegación simulada sobre la anatomía del paciente.
In the neurosurgery field, the technological support through specialized equipment and medical applications has become a need. Neurosurgeons often make use of computer assisted systems and neuronavigators as auxiliary tools during the preoperative and intraoperative phases of the surgery. These technological resources allow them to plan the surgical approach in a fast, efficient and interactive way; also, making minimally invasive surgical techniques, such as stereotactic surgery, easier to use. In this work, we present the use of a neuronavigation medical application we developed in the preoperative planning of a frame-based stereotactic procedure to remove an arachnoidocele lesion. This software features support for handling images and information in conformance with the DICOM standard, direct rendering of volumetric data through 2D and 3D texture mapping, displaying of multimodal images and the segmentation of anatomical structures. By using the planning software, neurosurgeons can define the surgical approach protocol and trajectory, while doing the simulated navigation through the patient anatomy.
