The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival.

PARP family members can be found spread across all domains and continue to be essential molecules from lower to higher eukaryotes. Poly (ADP-ribose) polymerase 1 (PARP-1), newly termed ADP-ribosyltransferase D-type 1 (ARTD1), is a ubiquitously expressed ADP-ribosyltransferase (ART) enzyme involved in key cellular processes such as DNA repair and cell death. This review assesses current developments in PARP-1 biology and activation signals for PARP-1, other than conventional DNA damage activation. Moreover, many essential functions of PARP-1 still remain elusive. PARP-1 is found to be involved in a myriad of cellular events via conservation of genomic integrity, chromatin dynamics and transcriptional regulation. This article briefly focuses on its other equally important overlooked functions during growth, metabolic regulation, spermatogenesis, embryogenesis, epigenetics and differentiation. Understanding the role of PARP-1, its multidimensional regulatory mechanisms in the cell and its dysregulation resulting in diseased states, will help in harnessing its true therapeutic potential.

PP172. Indian scenario of preeclampsia and its consequences and early prophylaxis.

INTRODUCTION: Preeclampsia remains one of the major obstetrical problems in less-developed countries. The causes of this condition are still unknown, we have designed a prevention protocol with new concept to describe the etiology and cause of preeclampsia. OBJECTIVES: To study the effectiveness of the Jariwala's therapy and etiological causes of preeclapsia. we want to establish the new version of efficient prophylactic management to prevent the concequences of preeclampsia. METHODS: We have selected 800 cases who have developed preeclampsia during any phase of pregnancy and tried to prevent the developing preeclampsia (predicted with roll over test, color doppler and weight gain and or edema) by Jariwala's protocol. our aim is to reduce the severity of disease process by early prediction and treatment. we have not included the cases who may have completely treated after the inclusion criteria to predict the preclampsia and treated. the inclusion criteris is strictly followed by a protocol designed. RESULTS: Jariwala's therapy is effective in mild to moderate cases of preeclampsia. Till date we have successfully treated 800 cases of mild to moderate preeclapsia with 98% neonates delivered with birth weight of 2kg and more, 92% neonates sent directly to home without any complication; and developed well at home. CONCLUSION: If we try to treat the blood pressure (during pregnancy) by anti hypertensive we have noticedà IUGR and rebound increase of blood pressure, means decrease maternal blood pressure à decrease placental supplyà deficient nutrientà rebound increase in toxin secretion (by fetus and placenta) à increase in blood pressure to supply more nutrient). So that it is my suggestion that the antihypertensive should be avoided if possible 2: increase permeability of placental membranes due to toxins secreted by fetus to supply more nutrient leads to increase permeability of placental membranes means increase protein loss from kidneys (due to toxins secreted from the fetus and placenta) increase third space leakage of fluid as nutrient leads to serum protein deficiency and increase permeability of endovascularities of all organs multi system disorder. so instead of treating the developing preeclampsia with routine treatment either terminate the pregnancy if it is severe and developing intensely or treat with the Jariwala's protocol.

Sensory deficit in the hands of children with cerebral palsy: a new look at assessment and prevalence.

The sensory function of the hand was assessed in 55 children with cerebral palsy (CP) and 15 control children with lower-limb involvement after poliomyelitis by testing stereognosis and two-point discrimination. A 0 to 10 per cent error in the post-polio group defined normal limits, according to which 51 per cent of the CP group showed impairment on one or both of the tests. These results confirm those of studies carried out 30 to 40 years ago, and draw attention to a neglected aspect of CP in which the possibility of therapeutic intervention has yet to be adequately explored.