[Prognostic value of the initial response of serum estradiol levels to stimulation with GnRH analogues in in vitro fertilization]. / Valor pronóstico de la respuesta inicial de los niveles séricos de estradiol al estímulo con análogos de GnRH en fertilización in vitro.

Studying the value prognostic of the answer of the Estradiol (E2) levels to the stimulation with agonists of GnRH (GnRH-a) during early follicular phase. Retrospective, analytic and comparative study. From January 1, 1993 to December 31, 1995 403 IVF cycles were studied. According to E2 levels after stimulation with GnRH-a four Patterns were assembled. Pattern A (n = 115), B (n = 22), C (n = 11), and D (n = 3). Those was included patients managed in short luteal phase in this study, (FLC) (n = 153) and long luteal phase (FLL) (n = 97) were groups control. The rate of oocyte retrieve was greater in the patterns, A, B, FLC and FLL with respect to the patron D (p = 0.001). The pregnancy rate was higher in A, B, FLC and FLL (25%, 19%, 22% and 25% respectively (p = 0.05). The age was old in C and D and luteal phase with an average of 35 +/- 2 (p = 0.001). The patterns had a better answer, represented by the increment of the estradios (E2) levels response to the GnRH-a action of leuprolide acetate during the early follicular phase they went A and B. We conclude that the early E2 response patterns to leuprolide acetate is the best early prognostic indicator of IVF outcome.