RESUMO
We studied 29 patients with major depression before treatment and then followed these patients prospectively with monthly electroencephalographic (EEG) sleep assessments after successful treatment. Most EEG sleep measures demonstrated no change from the episode throughout a prolonged period of clinical remission. When there was evidence of a change in EEG sleep measures, the effect was modest and due to only a small subset of patients. These findings contribute to the accumulating evidence that selected EEG sleep measures appear to be trait-like and may be useful in identifying individuals at risk for major depression.
Assuntos
Antidepressivos Tricíclicos/uso terapêutico , Terapia Cognitivo-Comportamental , Transtorno Depressivo/terapia , Eletroencefalografia , Polissonografia , Adulto , Amitriptilina/uso terapêutico , Córtex Cerebral/efeitos dos fármacos , Córtex Cerebral/fisiopatologia , Terapia Combinada , Transtorno Depressivo/fisiopatologia , Transtorno Depressivo/psicologia , Desipramina/uso terapêutico , Método Duplo-Cego , Eletroencefalografia/efeitos dos fármacos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Fases do Sono/efeitos dos fármacos , Fases do Sono/fisiologiaRESUMO
In 1988, the MacArthur Foundation Research Network on the Psychobiology of Depression convened a task force to examine the ways in which change points in the course of depressive illness had been described and the extent to which inconsistency in these descriptions might be impeding research on this disorder. We found considerable inconsistency across and even within research reports and concluded that research on depressive illness would be well served by greater consistency in the definition change points in the course of illness. We propose an internally consistent, empirically defined conceptual scheme for the terms remission, recovery, relapse, and recurrence. In addition, we propose tentative operational criteria for each term. Finally, we discuss ways to assess the usefulness of such operational criteria through reanalysis of existing data and the design and conduct of new experiments.
Assuntos
Transtorno Depressivo/diagnóstico , Projetos de Pesquisa , Terminologia como Assunto , Transtorno Depressivo/psicologia , Transtorno Depressivo/terapia , Humanos , Inventário de Personalidade , Escalas de Graduação Psiquiátrica , Recidiva , Reprodutibilidade dos Testes , Projetos de Pesquisa/normas , Projetos de Pesquisa/estatística & dados numéricos , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
In this longitudinal study of 25 successfully treated depressed patients, rapid eye movement (REM) latency during an episode of depression was evaluated as a predictor of recurrence. Patients with reduced REM latency prior to treatment were more likely to develop another episode of depression during the follow-up period.