RESUMO
THz-TDS techniques are applied to investigate selected pharmaceutical samples. Investigations were performed on selected pharmaceutical samples with active pharmaceutical ingredients (API)--famotidine, ranitidine, fenofibrate, lovastatin, simvastatin, aspirin, ketoconazole, acyclovir (hydrated and non-hydrated), on excipients--lactose, glucose (hydrated and non-hydrated), Pluronic 127, and on mixtures of selected compounds. Pseudo-polymorphism effects are considered as well. Examples of the terahertz imaging technique are also given. APIs and excipients can be easily recognized in the terahertz band by their specific "fingerprints" as individual components and in mixtures. The hydration process as a variety of polymorphism can also be easily monitored using the THz technique. Moreover, terahertz light can be useful for the penetration of tablets, giving clear pictures of possible defects in tablet coatings.
Assuntos
Preparações Farmacêuticas/análise , Espectroscopia Terahertz/métodos , Excipientes/análise , ComprimidosRESUMO
In the paper, Fourier transform has been used for calculations of a refractive index of dielectric samples measured in the terahertz photomixer arrangement. We considered measurement limitations caused by a sampling frequency and a photomixer bandwidth.
