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Hum Immunol ; 73(8): 811-7, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22651916

RESUMO

HLA-G is a nonclassical, class I major histocompatibility complex (MHC) gene that exhibits immunomodulatory properties and likely plays a role in the maintenance of successful pregnancy. In this study, we investigated the role of HLA-G polymorphisms on risk for recurrent pregnancy loss (RPL) and on circulating levels of soluble (s)HLA-G in Iraqi women. DNA and plasma were obtained from blood samples collected at 9-12 weeks gestation from 50 women with RPL and 50 healthy pregnant women in Basrah province, Iraq. As measured by ELISA, median sHLA-G levels were significantly lower in the RPL cases compared to healthy controls (21.4 vs. 38.8 U/ml, respectively; P=0.025), and decreased with increasing maternal age (P=0.0051). However, HLA-G allele and haplotype frequencies did not differ significantly between cases and controls (P values ≥0.12 for all tests). In contrast, homozygosity for the C allele (CC) at a tri-allelic promoter polymorphism, -725C/G/T, was associated with lower concentrations of sHLA-G compared to the CG or CT genotypes (median levels 21.1 vs. 40.1 vs. 42.6 U/ml, respectively; P=0.0089). These results demonstrate that HLA-G genotype influences circulating sHLA-G levels during pregnancy but is not significantly associated with risk of RPL.


Assuntos
Aborto Habitual/genética , Antígenos HLA-G/genética , Polimorfismo Genético , Aborto Habitual/imunologia , Adulto , Alelos , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Feminino , Frequência do Gene , Genótipo , Antígenos HLA-G/imunologia , Haplótipos , Humanos , Iraque , Idade Materna , Gravidez , Primeiro Trimestre da Gravidez , Fatores de Risco , Solubilidade
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