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1.
World J Pediatr Congenit Heart Surg ; 15(1): 130-133, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37661701

RESUMO

Sinus of Valsalva aneurysm (SVA) is an abnormal dilatation of the aortic root located between the aortic valve annulus and the sinotubular junction and is rare in the pediatric population. This case report describes a unique case of a 16-year-old adolescent patient admitted with progressive heart failure symptoms and diagnosed with a ruptured noncoronary SVA. He underwent surgical repair of the SVA with autologous pericardial patches and had an uncomplicated postoperative course. A genetic workup revealed an underlying 22q11.2 deletion that is infrequently associated with SVA.


Assuntos
Aneurisma Aórtico , Ruptura Aórtica , Insuficiência Cardíaca , Seio Aórtico , Adolescente , Humanos , Masculino , Aorta , Aneurisma Aórtico/complicações , Aneurisma Aórtico/diagnóstico por imagem , Aneurisma Aórtico/cirurgia , Ruptura Aórtica/complicações , Ruptura Aórtica/diagnóstico por imagem , Ruptura Aórtica/cirurgia , Insuficiência Cardíaca/cirurgia , Insuficiência Cardíaca/complicações , Seio Aórtico/diagnóstico por imagem , Seio Aórtico/cirurgia
2.
Curr Stem Cell Res Ther ; 14(1): 65-74, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30227823

RESUMO

Islet cell auto-transplantation is a novel strategy for maintaining blood glucose levels and improving the quality of life in patients with chronic pancreatitis (CP). Despite the many recent advances associated with this therapy, obtaining a good yield of islet infusate still remains a pressing challenge. Reprogramming technology, by making use of the pancreatic exocrine compartment, can open the possibility of generating novel insulin-producing cells. Several lineage-tracing studies present evidence that exocrine cells undergo dedifferentiation into a progenitor-like state from which they can be manipulated to form insulin-producing cells. This review will present an overview of recent reports that demonstrate the potential of utilizing pancreatic ductal cells (PDCs) for reprogramming into insulin- producing cells, focusing on the recent advances and the conflicting views. A large pool of ductal cells is released along with islets during the human islet isolation process, but these cells are separated from the pure islets during the purification process. By identifying and improving existing ductal cell culture methods and developing a better understanding of mechanisms by which these cells can be manipulated to form hormone-producing islet-like cells, PDCs could prove to be a strong clinical tool in providing an alternative beta cell source, thus helping CP patients maintain their long-term glucose levels.


Assuntos
Reprogramação Celular , Células Secretoras de Insulina/fisiologia , Transplante das Ilhotas Pancreáticas/métodos , Pancreatite Crônica , Regeneração , Transplante Autólogo , Animais , Glicemia/metabolismo , Humanos , Camundongos , Ductos Pancreáticos/fisiopatologia , Pancreatite Crônica/sangue , Pancreatite Crônica/complicações , Pancreatite Crônica/genética , Pancreatite Crônica/terapia , Ratos , Células-Tronco/fisiologia
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