1.
Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.
Bioorg Med Chem Lett
; 19(18): 5452-7, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19666223
RESUMO
A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 microM) overall and ring stage in vitro antimalarial activity.