[Development of ulcerative colitis in a male patient during exacerbation of Reiter's syndrome symptoms]. / Wystapienie wrzodziejacego zapalenia jelita grubego u mezczyzny podczas kolejnego nasilenia objawów zespolu Reitera.

Three years observation of a male patient was presented, who manifested Reiter's syndrome with two relapses of the disease, associated with the typical triad of symptoms (acute arthritis, conjunctivitis, urethritis). Both relapses were accompanied by diarrhoea. In course the first relapse skin lesions were observed on both shanks, diagnosed as erythema nodosum. Complex studies on diarrhoea, performed during the first relapse, failed to doxycyclin and diclofenac. During the second relapse of Reiter's syndrome the diarrhoea was diagnosed to result from co-existing colitis ulcerosa. Serum titers of Chlamydia trachomatis antibodies were low during relapse, increased during patient's recovery and persisted at the high during asymptomatic period. High titers of such antibodies were noted also in the serum of the patient's wife in whom neither anamnesis nor physical examination could demonstrate any pathology.

[Low molecular weight heparin (Fraxiparine) as adjunctive therapy with thrombolysis for acute myocardial infarction: a pilot study with a one year follow up]. / Drobnoczasteczkowa heparyna (Fraksyparyna) jako uzupe-nienie leczenia trombolitycznego swiezego zawalu serca; próba "pilotowa" z roczna obserwacja chorych.

In 53 patients with recent (< 6 hrs) acute myocardial infarction a study was undertaken to evaluate the safety of conjunctive therapy with streptokinase (1.5 mln U), aspirin (150 mg) and low molecular weight heparin (Fraxiparine). Patients were treated with Fraxiparine 250 U anti-Xa IC/kg/24 hrs iv for 2 days (with bolus 12.5 U anti-Xa IC/kg), and 125 U anti-Xa IC/kg twice a day sc for 5 subsequent days. Clinical course in one-year observation was compared regarding the time the therapy was initiated. In the group undergoing therapy 3-6 hrs after the infarct had occurred 4 (7.5%) patients died (2 during hospitalization, 2 after discharge). In 31 patients treated within 3 hrs of the myocardial infarction there were fewer cases of recurrent myocardial infarction, unstable angina or congestive heart failure necessitating rehospitalization their (9.1%) than in 22 patients included in the treatment regimen between 3 rd and 6th h of the infarction (27.3%). Earlier thrombolysis was also connected with higher left ventricular ejection fraction (55 +/- 8% vs 49 +/- 10%) and more frequent peak CK-MB values 12 hrs after thrombolysis (81% and 68% of patients respectively). Neither symptomatic deep vein thrombosis nor pulmonary embolism was detected. The left ventricular thrombosis was diagnosed by echocardiography in 4 of 20 patients (20%) with the first anterior myocardial infarction. There was neither bleeding requiring blood transfusion nor cerebrovascular stroke. The treatment with Fraxiparine did not induce the prolongation of APTT values. Conjunctive thrombolytic therapy with low molecular weight heparin was safe and followed by a favorable outcome of the acute myocardial infarction, especially if instituted within the first 3 hrs after the onset of infarction.