RESUMO
The functionalization of sp3 carbons is deemed challenging in synthetic organic chemistry yet has tremendous potential in producing potent organic compounds. A facile synthesis of 2,4,5-trisubstituted oxazoles through an oxidative, copper-catalyzed, and solvent-free annulation is described. Various arylated oxazoles were efficaciously synthesized at a mild temperature from readily available substrates under a molecular oxygen atmosphere. Preliminary mechanistic studies suggested that the reaction proceeds via an anionic-type mechanism and indicated the formation of a keto-imine intermediate. The reaction is notable for the abstraction of six hydrogen atoms, the functionalization of one sp2 carbon and two sp3 carbons, and the formation of C-O and C-N bonds.
RESUMO
In this study, we investigated a series of triarylimidazoles, in an effort to elucidate critical SAR information pertaining to their anti-plasmodial and ß-hematin inhibitory activity. Our results showed that in addition to the positional effects of ring substitution, subtle changes to lipophilicity and imidazole ionisability were important factors in SAR interpretation. Finally, in silico adsorption analysis indicated that these compounds exert their effect by inhibiting ß-hematin crystal growth at the fast growing 001 face.
RESUMO
A sequential one-pot approach to 2,4,5-trisubstituted imidazoles has been developed from α-methylene ketones and aldehydes. This methodology employs air-moisture stable reaction conditions and an inexpensive iodine/DMSO system affording a diverse range of known and novel (substrate scope) 2,4,5-trisubstituted imidazoles in moderate to excellent yields. The iodine/DMSO system was extended to the domino convergent synthesis of two functionalized intermediates, benzil and benzaldehyde, to produce the final product.
RESUMO
In 1985, Robert Ireland and co-worker were devising synthetic routes to polyether ionophore antibiotics and during this process several highly reactive aldehydes were encountered, which made their isolation and subsequent elaboration difficult. To circumvent this problem, the synthetic route commenced from the alcohol which was oxidized to the aldehyde and, to the crude mixture, was added the nucleophile. This procedure, dubbed the 'Ireland' oxidative process was found to be highly successful and adapted by many research groups the world over. As we celebrate 30 years since this landmark discovery, the following review will take a journey of the most innovative and wonderful applications of this process.
RESUMO
A mechanistic investigation into the photooxidation of alcohols using dye sensitised titanium dioxide and dye sensitised zinc oxide is described. The varying yields using the two photocatalysts have been explained using electron paramagnetic resonance (EPR) spectroscopy, which indicated that electron injection occurs in the dye sensitised ZnO system but is sluggish in the dye sensitised TiO(2) system. Due to the failure of the electron injection step, a 'break' in the photooxidative system occurs resulting in a decrease in the conversion of benzyl alcohol to benzaldehyde for the dye sensitised TiO(2) system.
RESUMO
A novel photooxidative system using dye sensitised zinc oxide in combination with silver nitrate and 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) in an aqueous solution is described. Under visible light irradiation the selective oxidation of alcohols to their corresponding aldehydes and ketones was effected in good to excellent yields.
RESUMO
The application of titanium dioxide as an oxidant in tandem oxidation type processes is described. Under microwave irradiation, quinoxalines have been synthesized in good yields from the corresponding alpha-hydroxyketones.