RESUMO
Multiple magnet ingestion is an unexpected health hazard in children that can lead to significant gastrointestinal morbidity. The magnets are attracted to each other across the bowel wall and this may lead to pressure necrosis, resulting in perforation, fistula formation, and/or intestinal obstruction. We report herein a case of small bowel obstruction following ingestion of two magnets. The public and clinicians should be aware of the health hazard of such devices.
Assuntos
Deglutição , Corpos Estranhos/complicações , Gastroenterite/etiologia , Magnetismo , Pré-Escolar , Corpos Estranhos/diagnóstico por imagem , Humanos , Masculino , RadiografiaRESUMO
Glutathione (GSH) is an ubiquitous thiol-containing tripeptide that plays a key role in cell biology. It modulates cell response to redox changes associated with the reactive oxygen species, detoxifies the metabolites of drugs; regulates gene expression and apoptosis, and is involved in the transmembrane transport of organic solutes. Polymorphism has been observed in key enzymes of GSH metabolism and some alleles have been associated with an impaired redox buffer system downsteam diseases, and susceptibility to ischaemia. These varied activities make GSH an attractive target for a more reductionist approach to the prevention and management of many conditions of interest to surgeons.
Assuntos
Glutationa , Glutationa/química , Glutationa/fisiologia , Glutationa Peroxidase/fisiologia , Glutationa Transferase/fisiologia , Humanos , Doenças Inflamatórias Intestinais/metabolismo , Neoplasias/metabolismo , Oxirredução , Traumatismo por Reperfusão/metabolismo , Sepse/metabolismoRESUMO
Glutathione plays an important cytoprotective role in the gut. Animal studies have demonstrated that the provisions of glutathione precursors are protective for different types of free-radical-mediated cellular injury. There is a need to clarify the potential role of glutathione supplementation in ischemia-reperfusion injury and inflammatory bowel disease. More speculative is whether treatment with glutathione precursors can modify the progress of colorectal cancer.
