Efecto hipotensor inducido por metoclopramida en sujetos normotensos e hipertensos / Effect of intravenous metoclopramide on blood pressure in normotensive and hypertensives

En el presente estudio evaluamos el efecto de la metoclopramida intravenosa sobre la presión sanguínea en sujetos normotensos (no entrenados, futbolistas, corredores) y en pacientes hipertensos. Hubo una disminución de la presión arterial sólo observado en sujetos femeninos no entrenados y esta fue más grande en sujetos hipertensos. En futbolistas y corredores, la disminución en la presión arterial fue estadísticamente no significativa. Hubo un efecto no significativo sobre la frecuencia cardíaca. El mecanismo probable de este nuevo efecto farmacológico de la metoclopramida es desconocido; sin embargo, actualmente se están realizando investigaciones para definir su mecanismo de acción

Cardiac workload during exercise under metoclopramide treatment / Presión sanguinea del paciente cardiaco durante el ejercicio y bajo un tratamiento con metoclopramida

Cardiac workload was determined in normotensive and hypertensive subjects during submaximal treadmil exercise under metoclopramide treatment at the José Gregorio Hernández Hospital and at the Vargas Hospital, Caracas, Venezuela. Subjects were submitted to treadmil exercise during a 30 min period of 5 por ciento glucose solution administration (before and after metoclopramide) and during a 30 min period of metoclopramide, 7.5 µg/Kg/min administration. Treadmill exercise induced an increase of cardiac Workload in both normotensive and hypertensive subjects. Metoclopramide induced a decrease of cardiac workload in normotensives and less in hypertensives. We conclude that metoclopramide, a known DA2 dopaminergic blocker, reduces cardiac workload during keadmill exercise in normotensive and hypertensive subjects

Metoclopramide-Induced Vascular Hyperreactivity: A Comparative Study Between Normotensive and Hypertensive Subjects.

In the present study, we have evaluated the cardiovascular responses to the cold pressor test (CPT) under intravenous metoclopramide (MTC) treatment (7.5 &mgr;g kg(minus sign1) min(minus sign1)) during a 30-min period and two additional periods, before and after MTC by using 5% glucose solution. There was a vascular hyperreactivity induced by MTC, Delta mm Hg was 21.4/24/1 mm Hg (systolic/diastolic blood pressure [BP]) during MTC versus Delta 17.2/17.9 mm Hg during 5% glucose infusion. In nine hypertensive subjects, Delta mm Hg was 36.8/25.7 during MTC versus Delta 31/24 mm Hg during 5% glucose. Bromocriptine pretreatment (7.5 mg daily for 7 days) antagonized MTC-BP increase during CPT. We conclude the following: (1) MTC induces a greater BP response during CPT which is blocked by using bromocriptine, a known DA(2) dopaminergic agonist. (2) A dopaminergic influence is present during CPT in normotensive and hypertensive subjects.