1.
Chem Commun (Camb)
; 52(32): 5637-40, 2016 Apr 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27034247
RESUMO
A simple peptide based prodrug of camptothecin (CPT) has been synthesised in which the CPT is conjugated to a tripeptide (KCK) via a disulfide linkage (KCK-CPT) and self-assembled into well-defined nanostructures in water depending on the concentration. The hyaluronic acid (HA) complex of KCK-CPT exhibited target specific toxicity with excellent antitumour efficiency.
Assuntos
Antineoplásicos/administração & dosagem , Ácido Hialurônico/química , Nanoestruturas , Peptídeos/administração & dosagem , Microscopia Confocal
2.
Chem Commun (Camb)
; 50(90): 14006-9, 2014 Nov 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25266767
RESUMO
ABA-type amphiphiles bearing a triazole-based aromatic block were easily synthesized using click chemistry, which act as fluorescent turn-off Hg(2+)-chemoprobes in an aqueous solution. Interestingly, the metal-binding process of amphiphiles induced nanoassemblies even below the CMCs, and the binding stoichiometry affected the morphologies of the resultant nanostructures.