Mutation of p53 Gene and Infection of Human Papillomavirus in Oral and Oropharyngeal Carcinoma / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Oral and oropharyngeal squamous cell carcinomas (SCC) are diseases that are largely attributed to environmental exposure. Tobacco use and alcohol consumption are well-established risk factors. However, small proportions of oral and oropharyngeal SCCs occur also in nonsmokers and nondrinkers, suggesting the presence of other risk factors. We investigated etiologic role of Human papillomavirus (HPV) in patients with oral and oropharyngeal SCCs and the association between infection with HPV and p53 alteration in oral and oropharyngeal SCCs. MATERIALS AND METHOD: Tumor tissues from 46 patients with oral and oropharyngeal SCCs were examined for the presence of HPV type 16 and 18 genome by polymerase chain reaction (PCR), and the p53 status of each tumor was analysed by sequencing and immunohistochemistry. RESULTS: Thirty-six (78.3%) of 46 cases revealed overexpression of p53 protein and 14 (30.4%) had p53 mutation. The rate of p53 overexpression was much higher in smokers than in nonsmokers (p=0.003). HPV was detected in 8 (17.4%) of 46 cases and all were HPV type 16. As compared with HPV-negative carcinomas, HPV-positive cancers were less likely to occur among smokers (p=0.001) and to have p53 mutation and p53 overexpression (p=0.007), and had a moderately and poorly differentiated cancer characteristic. CONCLUSION: The alteration of p53 is related to smoking which is counteractive to the presence of HPV infection, which can be considered as an independent etiologic factor in oral and oropharyngeal SCCs.

A Case of Infraorbital Protrusion of Postoperative Cheek Cyst / 대한이비인후과학회지

The postoperative cheek cyst develops as a delayed complication, usually 10 to 20 years after the Caldwell-Luc operation. The most common symptoms are swelling or pain of the cheek and the mucogingival fold of the maxilla. The pathophysiology of postoperative cheek cyst is under debate. Clinically bony destruction of infraorbital portion of orbit is rare. Recently, we experienced a case of a postoperative cheek cyst which had a infraorbital protrusion, so we report this rare case with the review of literatures.

A Case of Transient Glossopharyngeal and Hypoglossal Nerve Palsy after Laryngomicrosurgery / 대한이비인후과학회지

Laryngomicrosurgery is a common procedure in the otolaryngological fields. Transient glossopharyngeal and hypoglossal nerve palsy after laryngomicrosurgery are very rare. Recently, we experienced a palsy of glossopharyngeal and hypoglossal nerve which occurred after laryngomicrosurgery. We report this rare case with the review of literature.

A Case of Herpes Zoster Oticus Involving Unilateral 9th and 10th Cranial Nerves without Facial Palsy / 대한이비인후과학회지

Herpes zoster oticus is a viral disease associated with otalgia, vesicular eruptions, facial paralysis, hearing disturbance, tinnitus, vertigo and other symptoms. Among cranial nerves, trigeminal and facial nerves are the most commonly affected in patients with herpes zoster oticus, but on rare occasions 8th, 9th, 10th, 11th, 12th cranial nerves are influenced as well. Authors ex-perienced a case of herpes zoster oticus involving glossopharyngeal nerve and vagal nerve without facial palsy in a 58-year-old male. We report this case with a review of literatures.

A Case of Horner's Syndrome with Temporary Compressive Optic Neuropathy after Endoscopic Sinus Surgery / 대한이비인후과학회지

Retrobulbar hematoma is one of the major complications following endoscopic sinus surgery (ESS). Symptoms and physical findings include temporary blindness, ophthalmoplegia, mydriasis, ptosis, proptosis and eyelid ecchymosis. Recently, we experienced a rare case of the left Horner's syndrome with compressive optic neuropathy resulting from bilateral delayed retrobulbar hematoma after ESS. There is no literature about the Horner's syndrome as a complication of ESS at present. We hereby present this case with an emphasis on the importance of prevention, identification and management of retrobulbar hematoma.

A Clinical Analysis of Facial Bone Fractures Excluding Nasal Bone Fractures / 대한이비인후과학회지

BACKGROUND: The number of facial bone fractures are steadily increasing because of increment of traffic volume and expansion of social activity. Also the forms of the fractures show to be more complicated due to increase of traffic vehicles. Facial region has an important role in human aesthetic and functional aspects. Therefore, it it very important to diagnose accurately and treat promptly and appropriately the fracture, to minimize deformity and functional disturbance in the face and enable the patient to socialize normally. OBJECTIVE: Our objective of this study is to elucidate general characteristics of clinical aspect in the facial bone fractures by analyzing the cases with facial bone fractures who diagnosed and treated at Nam Kwang Hospital for recent 2 years. MATERIALS AND METHODS: The authors reviewed retrospectively the medical records of 115 patients among 200 patients with facial bone fractures, excluding 85 patients who had only nasal bone fractures, diagnosed and treated at Nam Kwang Hospital from Jan. 1995 to Dec. 1996. The records of the cases were examined and analyzed according to sex and age distribution, cause of injury, symptoms and signs, associated injuries, frequency and treatment modality in each region, and complications. Results and CONCLUSIONS: The results were as follows; 1) Ninty cases(78.3%) were male and the peak age group was third decade(33.0%). 2) The most common cause of injury was motor vehicle accident(53.0%). 3) The most common symptoms and signs were pain, tenderness and edema(100%). 4) The most common associated injury was soft tissue injury(58.3%). 5) Single facial bone fracture was more common(68.7%) and among them, mandibular fracture was the most common. 6) The incidences of anatomical locations of facial bone fracture were mandible(45.2%), zygoma(39.1%), maxilla(17.4%) and frontal bone(14.8%), in order of frequency. 7) In zygomatic fractures, arch fracture was the most common(46.7%). 8) In maxillary fractures, complete Le Fort fracture type I was the most common(20.0%). 9) In orbital fractures, pure blow-out fracture was the most common(52.9%). 10) In mandibular fractures, symphysis and parasymphysis were the most common anatomical site(48.1%). 11) The cases treated with surgical approach were 70.4%. 12) The most common complication was infraorbital nerve dysfunction(6.1%).

Clinical Analysis of Infectious Mononucleosis / 대한이비인후과학회지

Infectious mononucleosis is most commonly caused by Epstein-Barr virus(EBV) and is a self-limited but occasionally life-threatening. Its peculiar characteristics are sore throat, cervical lymphadenopathy and hepatosplenomegaly. Recently, the age of primary EBV infection is becoming late in Korea due to socioeconomic development. So the authors retrospectively reviewed the cases of infectious mononucleosis. The results of clinical and laboratory findings suggest that infectious mononucleosis should be considered as a cause of pharyngotonsillitis and the assessment of viral capsid antigen(VCA) IgM is necessary for the diagnosis of this disease.

Electron microscopic study of utricular macula in alloxan diabetic rat / 대한이비인후과학회지

No abstract available.