[Ancillary chemotherapy with trofosfamid, methotrexate and fluoro-uracil in cancer of the breast (author's transl)]. / Adjuvante Chemotherapie mit Trofosfamid, Methotrexat und Fluoro-uracil beim Mammakarzinom.

The results of adjuvant chemotherapy in the treatment of primary cancer of the breast is reported. During 44 months 401 patients were admitted to the prospective study. All patients with a cancer of the breast T1a-3a, N0-1b, M0 were operated by modification of the Patey procedure. N+ patients were treated for one year postoperatively with TMF chemotherapy (trofosfamid, methotrexate and Fluoro-uracil). Patients without lymph node metastases were not treated. After 44 months the recurrence rate in the TMF group was 16.2%, in the group without chemotherapy 9.8%. The recurrence rate in the treated group was 18.8% for post-menopausal patients and 13.8% in pre-menopausal patients. The number of distant metastases was higher than that of local recurrences. In the group without post-operative chemotherapy a higher number of recurrences occurred in the pre-menopausal patients (13.8%) than in the post-menopausal patients (7.5%). The proportion of local recurrences and distant metastases was the same in these patient groups. The experiences regarding the treatment plan and the side effects are the same as in comparable other studies of adjuvant chemotherapy. Several treatment plans are discussed which can lead to a reduction of the recurrence rate and to an improvement of the survival rates.

Paleocene hyracothere from polecat bench formation, wyoming.

A lower jaw of an eohippus (Hyracotherium cf. H. angustidens) from late Paleocene strata in Wyoming has extended the geological record of fossil horses into pre-Eocene time and suggests that the order Perissodactyla had an origin earlier than that heretofore conjectured. This specimen, together with equid teeth also possibly of late Paleocene age from Baja California, indicates that early perissodactyls were widespread on the North American continent before the Eocene epoch. Late Paleocene and early Eocene deposits of northwestern Wyoming have yielded many vertebrate rarities and "first or earliest occurrences" which require reappraisals of inter-and intracontinental dispersal patterns of the vertebrate grolups involved.

Early eocene bat from wyoming.

A fossil skeleton of an early Eocene bat, the oldest known flying mammal, was found in southwest Wyoming. The bat is assigned to the new species Icaronycteris index of the suborder Microchiroptera. It was apparently of a young male whose body was buried in varved marls of the Green River Formation, on the bottom of Fossil Lake, about 50 million years ago. The bones, some as slender as a human hair, show a few "primitive" characteristics such as a clawed index finger and a complete phalangeal formula, but the bat was fully developed -an anatomically precocious contemporary of the dog-sized polydactylous horse.