Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
2.
J Cutan Med Surg ; 23(5): 519-527, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31167568

RESUMO

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder. A genetic component in the pathogenesis is highly likely considering that ~30% to 40% of patients with HS report a family history of the disease. The genetic mutations related to HS that have been reported to date suggest HS can be inherited as a monogenic trait because of a defect in either the Notch signaling pathway or inflammasome function, or as a polygenic disorder resulting from defects in genes regulating epidermal proliferation, ceramide production, or in immune system function. This review provides a summary of genetic mutations reported in patients diagnosed with HS and discusses the mechanisms by which these genes are involved in its pathogenesis.


Assuntos
Secretases da Proteína Precursora do Amiloide/genética , Hidradenite Supurativa/genética , Inflamação/genética , Receptores Notch/genética , Humanos , Inflamassomos/genética , Mutação , Transdução de Sinais/genética , Fenômenos Fisiológicos da Pele/genética
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...