[Simultaneous Immobilization of Cadmium and Arsenic in Paddy Soils with Novel Fe-Mn Combined Graphene Oxide].

Novel Fe-Mn combined graphene oxide （GO-FM） material was produced and tested for its efficacy in remediating agricultural soil co-contaminated by Cd and As. In a 60-day soil incubation experiment， the remediation mechanism and immobilization effects of GO and GO-FM at different addition ratios （0.1%， 0.2%， and 0.3%） were investigated in Shangyu and Foshan soils， which had varying physicochemical properties and contamination degrees. The dynamic changes in pH， DOC concentration， bioavailable Cd and As content， and morphology of Cd and As were explored to determine the remediation efficacy of the materials. The results demonstrated that compared with that in the blank control， GO-FM increased the pH in Shangyu soil but decreased the pH in Foshan soil. After culture， both GO and GO-FM increased the soil DOC content. GO-FM decreased the soluble Cd concentration by 5.08%-19.19% and the bioavailability of Cd by 36.57%-42.8% in Foshan soil， and the main immobilization mechanism was electrostatic adsorption， complexation， and hydroxylated metal ion formation. The immobilization ability of GO-FM on Cd was lower than that of Foshan soil due to the influence of electrostatic repulsion in Shangyu acidic soil. However， with the increase in the amount of GO-FM， the trend of increasing the bioavailability of Cd by graphene oxide was inhibited. The addition of 0.2% and 0.3% GO-FM decreased the bioavailability of Cd by 6.45%-13.56% in Shangyu soil. Additionally， GO-FM decreased the bioavailability of As in Shangyu soil and Foshan soil by 4.34%-9.15% and 0.87%-5.71%， respectively. This was due to the immobilization mechanism of oxidation of As by manganese oxides and inner surface chelate between As and the surface hydroxyl group of iron oxides. In summary， the immobilization effect of GO-FM on Cd in Foshan soil was better than that in Shangyu soil， and the immobilization effect of GO-FM on As in Shangyu soil was better than that in Foshan soil， which can provide a theoretical basis and reference for the prevention and control of Cd and As co-contamination in different types of soil.

[Using Biochar and Iron-calcium Material to Remediate Paddy Soil Contaminated by Cadmium and Arsenic].

In this study, iron-calcium material (FC) and hickory-cattail biochar (BC) were applied to prepare composite material (BF), which was used to repair the combined pollution of cadmium and arsenic in paddy soil to reduce the content of cadmium (Cd) and arsenic (As) in rice grain. Soil pore water, rhizosphere soil, bulk soil, rice plants, and root iron plaque samples were collected during the growth period of rice in a pot experiment to explore the effects and mechanism of FC, BC, and BF on the bioavailability of Cd and As in paddy soil and their contents in plants. The results showed that biochar could significantly (P < 0.05) increase the pH value of bulk soil (0.55-0.66 units) and rhizosphere soil (0.28-0.36 units) and elevate the soil dissolved organic carbon (DOC) content. FC material could significantly (P < 0.05) reduce the pH of bulk soil (0.14-0.27 units) and rhizosphere soil (0.38-0.41 units), as well as the soil DOC content. Iron-calcium materials and composite could simultaneously reduce the contents of available Cd and As in soil pore water, rhizosphere soil, and bulk soil, whereas biochar could reduce the content of Cd but increase the content of As. Among them, a 1% addition of composite had the best effect. The available Cd and As in soil decreased by 41.8%-48.2% and 6.1%-10.1%, respectively. Biochar, iron-calcium materials, and composites improved plant biomass (dry weight of root, stem, leaf, and grain). For example, the dry weights of rice grains under these treatments were higher (48.5%-184.0%) than that of CK, as was the root iron plaque content (7.5%-13.6%). Compared with that in the CK, biochar could effectively reduce the Cd content in rice grain by 21.0%-26.1%. Iron-calcium material and composite could simultaneously reduce the Cd and As contents in rice grain. Among them, the BF treatment had the best effect on the reduction of Cd and As in rice grain, with a decrease of 36.9%-42.0% and 40.4%-44.4%, respectively. The Cd and As contents in rice grain were lower than the national standard values (GB 2762-2017).

Neoadjuvant Savolitinib targeted therapy stage IIIA-N2 primary lung adenocarcinoma harboring MET Exon 14 skipping mutation: A case report.

MET exon 14 skipping mutation (METex14m) is rare and occurs in approximately 1-4% of all non-small cell lung cancer (NSCLC) patients and approximately 2.8% of resected stage I-III NSCLC patients. Savolitinib is an oral, potent and highly selective type Ib MET inhibitor, which has been shown to be promising activity and acceptable safety profile in patients with advanced NSCLC harboring METex14m. Most recently, many studies have been probing into the feasibility and efficacy of target therapy for perioperative application in NSCLC. Interestingly, there are very few recorded cases of such treatments. Here, we presented that systemic treatment with the MET inhibitor savolitinib before surgery could provide the potential to prolong overall survival (OS) of patients with locally advanced potentially resectable NSCLC. A 49-year-old woman was diagnosed with stage IIIA (T2bN2M0) primary lung adenocarcinoma exhibiting a METex14m by real-time quantitative polymerase chain reaction (RT-qPCR). Given that the tumor load and the size of lymph nodes experienced a significant downstaging after the neoadjuvant treatment of savolitinib with 600mg once a day for 5 weeks, left lower lobectomy and systemic lymphadenectomy were successfully performed. The pathological response was 50% and the final postoperative pathological staging was pT1cN0M0, IA3 (AJCC, 8th edition). The case provides empirical basis for the neoadjuvant treatment with savolitinib in METex14m-positive locally advanced primary lung adenocarcinoma, which will offer some innovative insights and clinical evidence for more effective clinical treatment of neoadjuvant targeted therapy for METex14m-positive NSCLC.

The performance of detecting Mycobacterium tuberculosis complex in lung biopsy tissue by metagenomic next-generation sequencing.

BACKGROUND: Tuberculosis (TB) is a chronic infectious disease caused by the Mycobacterium tuberculosis complex (MTBC), which is the leading cause of death from infectious diseases. The rapid and accurate microbiological detection of the MTBC is crucial for the diagnosis and treatment of TB. Metagenomic next-generation sequencing (mNGS) has been shown to be a promising and satisfying application of detection in infectious diseases. However, relevant research about the difference in MTBC detection by mNGS between bronchoalveolar lavage fluid (BALF) and lung biopsy tissue specimens remains scarce. METHODS: We used mNGS to detect pathogens in BALF and lung biopsy tissue obtained by CT-guide percutaneous lung puncture (CPLP) or radial endobronchial ultrasound transbronchial lung biopsy (R-EBUS-TBLB) from 443 hospitalized patients in mainland China suspected of pulmonary infections between May 1, 2019 and October 31, 2021. Aim to evaluate the diagnostic performance of mNGS for detecting MTBC and explore differences in the microbial composition in the 2 specimen types. RESULTS: Among the 443 patients, 46 patients finally were diagnosed with TB, of which 36 patients were detected as MTBC positive by mNGS (8.93%). Striking differences were noticed in the higher detection efficiency of lung biopsy tissue compared with BALF (P = 0.004). There were no significant differences between the 2 specimen types in the relative abundance among the 27 pathogens detected by mNGS from the 36 patients. CONCLUSIONS: This study demonstrates that mNGS could offer an effective detection method of MTBC in BALF or lung tissue biopsy samples in patients suspected of TB infections. When it comes to the situations that BALF samples have limited value to catch pathogens for special lesion sites or the patients have contraindications to bronchoalveolar lavage (BAL) procedures, lung biopsy tissue is an optional specimen for MTBC detection by mNGS. However, whether lung tissue-mNGS is superior to BALF-mNGS in patients with MTBC infection requires further prospective multicenter randomized controlled studies with more cases.

Acute Respiratory Distress Syndrome Caused by Occupational Exposure to Waterproofing Spray: A Case Report and Literature Review.

Background: Acute respiratory distress syndrome (ARDS) is a serious respiratory disease, caused by severe infection, trauma, shock, inhalation of harmful gases and poisons and presented with acute-onset and high mortality. Timely and accurate identification will be helpful to the treatment and prognosis of ARDS cases. Herein, we report a case of ARDS caused by occupational exposure to waterproofing spray. To our knowledge, inhalation of waterproofing spray is an uncommon cause of ARDS, and what makes our case special is that we ruled out concurrent infections with some pathogens by using metagenomic next-generation sequencing (mNGS) as an auxiliary diagnosis, which presents the most comprehensive etiological examination of similar reports. Case Presentation: A previously healthy 25 years old delivery man developed hyperpyrexia, chest tightness, cough and expectoration. The symptoms occurred and gradually exacerbated after exposure to a waterproofing spray. The chest computed tomography (CT) finding showed diffuse ground glass and infiltrative shadows in both lungs. The diagnosis of ARDS related to waterproofing spray was established on the basis of comprehensive differential diagnosis and etiological examination. The patient achieved good curative effect after proper systemic glucocorticoid therapy. Conclusions: The diagnosis and differential diagnosis of acute respiratory failure for outdoor workers, such as delivery drivers or hikers, should be considered whether toxic aerosol exposure exists from daily contacts. The case can educate the public that more attention should be paid to avoid exposure to these chemicals by aerosols/ingestion mode and some preventive strategies should be taken in occupational environment. The treatment effect of glucocorticoids is significant in ARDS patients with general chemical damage caused by inhaling toxic gases and substances.

[Novel Insight into the Adsorption Mechanism of Fe-Mn Oxide-Microbe Combined Biochar for Cd(â ¡) and As(â ¢)].

A Fe-Mn oxide-microbe combined biochar (FM-DB) was prepared to simultaneously remove Cd(Ⅱ) and As(Ⅲ) contamination in an aqueous system. In the FM-DB, the best ratio of Fe-Mn oxide (FMBO) and carya cathayensis shell biochar (CCSB) was 3%+3%. The material had good acid resistance, mechanical strength, and mass transfer performance, and the maximum removal rates for Cd(Ⅱ) and As(Ⅲ) in the binary system were 77.29% and 99.94%, respectively. Characterization confirmed that the FM-DB was successfully prepared and had a rich functional group structure. The single-factor adsorption test results for Cd(Ⅱ) and As(Ⅲ) showed that the composite material had a certain adsorption capacity affected by initial pH, equilibration time, and initial concentration for Cd(Ⅱ) and As(Ⅲ) under different conditions. The adsorption isotherm and kinetic data indicated the adsorption equilibrium time for Cd(Ⅱ) and As(Ⅲ) was 3.5 h and 8 h, and the maximum capacity was 59.27 mg·g-1and 84.73 mg·g-1, respectively. The adsorption of Cd(Ⅱ) and As(Ⅲ) was mainly affected by the electron exchange, electron sharing, and complexation on the surface of the material. The whole adsorption process was a combination of single-layer adsorption and multi-layer adsorption on an uneven surface. The adsorption process was a multi-step process, including outer surface diffusion and inner particle diffusion. In addition, comparing the removal rate of composite materials in the single-component system and the binary system, a mutual promotion of adsorption between Cd(Ⅱ) and As(Ⅲ) was found under the binary system. In conclusion, oxide-microbe combined biochar could be an efficient adsorption material and was suitable for the remediation of aqueous system pollution caused by Cd(Ⅱ) and As(Ⅲ).

Organic photoredox catalytic amino-heteroarylation of unactivated olefins to access distal amino ketones.

Here we describe a metal-free amino-heteroarylation of unactivated olefins via organic photoredox catalysis, providing a concise and efficient approach for the rapid synthesis of various δ (ß, ε)-amino ketones under mild conditions. This protocol demonstrates that the new photocatalyst Cz-NI developed by our group has an excellent photoredox catalytic performance. Finally, a series of mechanistic experiments and DFT calculations indicate that this transformation undergoes a photoredox catalytic sequential radical addition/functional group migration process.

[Simultaneous Immobilization of Arsenic, Lead, and Cadmium in Paddy Soils Using Two Iron-based Materials].

Two iron-based materials, Fe-Ca composite (FeCa) and Fe-Mn binary oxide (FMBO), were applied to immobilize As, Pb, and Cd in heavy metal contaminated paddy soils. Seven kinds of paddy soil (tidal soil) contaminated by arsenic, lead and cadmium were collected from Shangyu, Shaoxing (SY), Foshan, Guangdong (FS), Shaoguan, Guangdong (SG), LiuYang, Hunan (LY), Ganzhou, Jiangxi (GZ), Dushan, Guizhou (DS), and Ma'anshan, Anhui (MAS). The effects of iron-based materials on the dynamic changes of As, Pb, and Cd concentration in soil solution, the stabilization efficacy of available As, Pb, and Cd in soil, and the effects of soil types and properties on stabilization efficacy were studied through soil incubation experiment. The results showed that the content of soil dissolved As, Pb, and Cd were lower in iron-based material treatments than in control throughout the incubation. The addition of two iron-based materials significantly reduced the availability of Cd, Pb, and As. Moreover, the stabilization efficiency of FeCa for As was higher than FMBO, but no significant difference was found in the stabilization efficiency of Pb and Cd between two materials. The stabilization efficiency of As, Pb, and Cd in FeCa treatments could be ordered as GZ > SG > DS and MAS; FS>SY, LY, and SG>MAS; SY, GZ, and DS>MAS, respectively. While the stabilization efficiency for As, Pb, and Cd in FMBO could be ordered as SY, LY, and GZ > DS > FS; FS > GZ > SY; DS > LY > MAS, respectively. In addition, the statistical results showed that the stabilization efficiencies of various soils under the treatment of iron-based materials were significantly correlated with sand content (negatively correlated for As), soil pH (positively correlated for Pb), and clay content (negatively correlated for Cd). In conclusion, the two iron-based materials evaluated in this study may be effective stabilization agents for remediating different types of arsenic-, lead-, and cadmium-contaminated soils.

Cumplimiento de los indicadores de calidad en la atención a pacientes con neumonía adquirida en la comunidad y su influencia sobre la evolución clínica / Compliance with quality indicators in the care of patients with community-acquired pneumonia and its influence on clinical evolution

INTRODUCCIÓN: La neumonía adquirida en la comunidad (NAC) es una infección frecuente. Genera numerosos ingresos hospitalarios y supone un gasto sanitario importante. Existen indicadores de calidad en el manejo de esta enfermedad. El objetivo del estudio fue evaluar en qué medida se cumplen estos indicadores y qué influencia tiene su cumplimiento sobre la evolución de la enfermedad. PACIENTES Y MÉTODOS: Estudio observacional retrospectivo de una muestra aleatoria de 300 pacientes ingresados por NAC en nuestro hospital. Se excluyeron neumonía nosocomial, pacientes pediátricos y los que habían requerido ingreso en unidad de críticos. Se analizó el grado de cumplimiento de los indicadores definidos en la Guía de Indicadores de Calidad de Neumomadrid y su influencia sobre la mortalidad y la necesidad de nueva atención médica. RESULTADOS: El cumplimiento de algunos indicadores fue deficiente: adecuación de la antibioterapia empírica (50,3%), aplicación de escalas pronósticas (17,0%) e inicio precoz del tratamiento antibiótico (83,0%). El infratratamiento y el inicio tardío de la antibioterapia se identificaron como factores de riesgo de mortalidad y de necesidad de nueva atención médica en los primeros 30 días, sobre todo, en los pacientes con índice de comorbilidad de Charlson ajustado por edad entre 3 y 8. CONCLUSIONES: Existen deficiencias en el cumplimiento de los indicadores de calidad de la NAC en nuestro centro. La mejora de estas deficiencias podría suponer una oportunidad para conseguir una evolución más satisfactoria de estos enfermos, dado que su incumplimiento se asocia a una mayor mortalidad y a la necesidad de nueva atención médica

INTRODUCTION: Community-acquired pneumonia (CAP) is a frequent infection. It generates numerous hospital admissions and supposes an important healthcare cost. There are quality indicators in the management of this disease. The objective of this study was to evaluate to what extent these indicators are met and what influence their compliance has on the evolution of the disease. PATIENTS AND METHODS: A retrospective observational study of a random sample of 300 patients admitted by CAP in our hospital. We excluded nosocomial pneumonia, pediatric patients and those who had required admission to a critical unit. The degree of compliance with the quality indicators defined in the Neumomadrid Quality Indicators Guideline and its influence on mortality and the need for new medical care was analyzed. RESULTS: The compliance with some indicators was deficient: adequacy of empirical antibiotic therapy (50.3%), application of prognostic scales (17.0%) and early initiation of antibiotic treatment (83.0%). The undertreatment and the late initiation of antibiotic therapy were identified as risk factors for mortality and the need for new medical care in the first 30 days, especially in patients with Charlson comorbidity index adjusted for age between 3 and 8. CONCLUSIONS: There are deficiencies in the compliance with the quality indicators in our hospital. The improvement of these deficiencies could represent an opportunity to achieve a more satisfactory evolution of these patients, since their non-compliance is associated with higher mortality and greater need for new medical attention

Related factors of prognosis of patients with gestational trophoblastic neoplasia after chemotherapy / 第二军医大学学报

Objective To explore the clinical factors influencing the prognosis of patients with gestational trophoblastic neoplasia (GTN) after chemotherapy. Methods The clinical data of 55 patients with gestational trophoblastic diseases in our hospital from 2009 to 2016 were retrospectively analyzed, including 26 cases with hydatidiform mole and 29 cases with GTN (23 cases of invasive mole and 6 cases of choriocarcinoma). Among them, 23 GTN patients with the follow-up human chorionic gonadotropin (HCG)5 U/L for 3 times after chemotherapy were included in this study. The age, reproductive history, lung metastasis, International Federation of Gynecology and Obstetrics (FIGO) stage and other clinical factors which might affect the cure time of GTN patients were analyzed by Cox regression analysis. The relationship between age and reproductive history and cure time were analyzed by Kaplan-Meier survival analysis. Results Cox regression univariate analysis showed that term delivery and abortion were related to the cure time of GTN patients (both P0.05), and the age was close to statistical significance (P=0.051). Cox multivariate analysis showed that term delivery was an independent factor influencing the cure time of GTN patients (P=0.020). Kaplan-Meier survival analysis showed that age (P=0.043), term delivery (P=0.016) and abortion (P=0.026) were related to the cure time of GTN patients after chemotherapy. Conclusion Older women or women who have histories of term delivery or abortion should be alerted to the occurrence of GTN, which has long cure time and the dynamic changes of blood HCG need to be closely monitored.

[A method for combining Fluoro-Jade B staining and immunofluorescent staining].

OBJECTIVE: To explore a method for combining Fluoro-Jade B (FJB) staining with immunofluorescent staining in rats with focal cortical infarction. METHOD: Permanent distal middle cerebral artery occlusion (dMCAO) was induced in rats by electrocoagulation. The rat models were randomized into two groups, and frozen sections of the brain tissues from each group were stained with FJB followed by immunofluorescent staining or in the reverse order. RESULTS: FJB staining followed by immunofluorescence staining clearly visualized both FJB-positive and immunofluorescence-positive cells in the frozen sections, but the staining protocol in the reverse sequence failed to clearly show the immunofluorescence-positive cells. CONCLUSION: FJB staining prior to immunofluorescence staining does not affect the staining effect of protein immunofluorescent staining and better visualizes the positive cells.

Synthesis and antitumor activity evaluation of lamiridosin A derivatives.

A series of lamiridosin A derivatives were synthesized through simple procedures. Their antitumor activities were evaluated against EC9706, MGC803, and B16 cell lines in vitro. Several compounds showed potent antitumor activity, especially compound 10, with IC50 value of 2.36 µmol/L against MGC803 cell lines, is more potent than marketed positive drug 5-fluorouridine (5-FU).

A method for combining Fluoro-Jade B staining and immunofluorescent staining / 南方医科大学学报

<p><b>OBJECTIVE</b>To explore a method for combining Fluoro-Jade B (FJB) staining with immunofluorescent staining in rats with focal cortical infarction.</p><p><b>METHOD</b>Permanent distal middle cerebral artery occlusion (dMCAO) was induced in rats by electrocoagulation. The rat models were randomized into two groups, and frozen sections of the brain tissues from each group were stained with FJB followed by immunofluorescent staining or in the reverse order.</p><p><b>RESULTS</b>FJB staining followed by immunofluorescence staining clearly visualized both FJB-positive and immunofluorescence-positive cells in the frozen sections, but the staining protocol in the reverse sequence failed to clearly show the immunofluorescence-positive cells.</p><p><b>CONCLUSION</b>FJB staining prior to immunofluorescence staining does not affect the staining effect of protein immunofluorescent staining and better visualizes the positive cells.</p>

[Chemical Constituents from Melissa officinalis Leaves].

OBJECTIVE: To investigate the chemical constituents of Melissa officinalis leaves. METHODS: The chemical constituents were separated by silica gel column chromatography and their structures were determined by spectroscopic experiments. RESULTS: 13 compounds were isolated and identified as protocatechuyl aldehyde(1), serratagenic acid(2), vanillin(3), 2α,3ß-dihydroxy-urs-12-en-28-oic acid(4), ursolic acid(5), oleanolic acid(6), daucosterol(7),2α,3ß,23,29-tetrahydroxyolean-12-en-28-oic acid-29-O-ß-D-gluco- pyranoside(8), luteolin(9) rosmarinic acid(10), luteolin-7-O-ß-D-glucoside (11), ß-stitosterol(12) and palmitic acid(13). CONCLUSION: Compounds 1 ~ 8 are separated from this plant for the first time and compounds 1-4 and 8 are isolated from this genus for the first time.

Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences.

AIM: To evaluate the efficacy of centralized culture and possible influencing factors. METHODS: From January 2010 to July 2012, 66452 patients with suspected Helicobacter pylori (H. pylori) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal endoscopy. Gastric mucosal biopsies were taken from the antrum for culture. These biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time: 5, 24 and 48 h. The culture results were reported after 72 h and the positive culture rates were analyzed by a χ (2) test. An additional 5736 biopsies from H. pylori-positive patients (5646 rapid urease test-positive and 90 (14)C-urease breath test-positive) were also cultured for quality control in the central laboratory setting. RESULTS: The positive culture rate was 31.66% (21036/66452) for the patient samples and 71.72% (4114/5736) for the H. pylori-positive quality control specimens. In the 5 h transport group, the positive culture rate was 30.99% (3865/12471), and 32.84% (14960/45553) in the 24 h transport group. In contrast, the positive culture rate declined significantly in the 48 h transport group (26.25%; P < 0.001). During transportation, the average natural temperature increased from 4.67 to 29.14 °C, while the positive culture rate declined from 36.67% (1462/3987) to 24.12% (1799/7459). When the temperature exceeded 24 °C, the positive culture rate decreased significantly, especially in the 48 h transport group (23.17%). CONCLUSION: Transportation of specimens within 24 h and below 24 °C is reasonable and acceptable for centralized culture of multicenter H. pylori samples.

[Microstructure study on bismuth triborate crystal and its melt at high temperature by Raman spectroscopy].

Temperature dependent Raman spectra of BiB3 O6 crystal and its melt were recorded and the microstructure of BiB3 O6 melt was predicted. Multiple theoretical methods including quantum chemistry ab initio calculation and DFT (Density Function Theory) methods were applied to simulate the BiB3 O6 crystal and melt structure and Raman spectra. It was demonstrated that B-O triangles and Bi lattice in the crystal reveal little affected in structure while B-O tetrahedra shows severe distortion with increasing temperature, especially B-O tetrahedra disappears after being completely melt. The microstructure of BiB3 O6 melt consists of six-member ring, [B6 O12](6-), which varies in bond lengths and angles individually. Cation Bi behaves to balance the charge of anion cluster, and the oxygen coordination number of cation Bi is 3, different from the crystal situation in which cation Bi is coordinated with 6 oxygens.

Investigations on the defect structures and the g factors for the two orthorhombic Ti3+ centers in CaYAlO4.

The defect structures and the g factors for the two orthorhombic Ti(3+) centers (A and B) in CaYAlO(4) are theoretically investigated from the perturbation formulas of the g factors g(xi), g(eta) and g(xi) for a 3d(1) ion in orthorhombically distorted octahedra. The centers may be attributed to Ti(3+) locating on the Al(3+) site associated with one nearest-neighbouring oxygen vacancy (V(O)) along the z (or c) axis and additional next-nearest-neighbouring Ti(4+) replacing the host Al(3+) (Ti(Al), i.e., center A) or Al(3+) vacancy (V(Al), i.e., center B) perpendicular to the c axis, respectively. Due to the electrostatic interactions arising from the local charge mismatch, the central Ti(3+) undergoes a large displacement DeltaZ away from the V(O) in the c axis, while the ligand O(2-) intervening in the Ti(3+) and Ti(Al) (or V(Al)) suffers a small outward (or inward) shift DeltaX in the corresponding c plane related to the center of oxygen octahedron. The theoretical g factors for both centers based on the above displacements are in reasonable agreement with the observed values.