RESUMO
In order to clarify the chemical constituents in Qiliqiangxin capsule, a rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry (UPLC-Q-TOF/MS(E)) method was established. Forty peaks were identified on line using this method. The herbal sources of these peaks were assigned. The results implied that triterpenoid saponins, flavonoid glycosides, C21-steroids and phenolic acids were included in the main components of Qiliqiangxin capsule. The method is simple and rapid for elucidation of the constituents of Qiliqiangxin capsule and the results are useful for the quality control of Qiliqiangxin capsule.
Assuntos
Medicamentos de Ervas Chinesas/química , Saponinas/análise , Triterpenos/análise , Cápsulas , Cromatografia Líquida de Alta Pressão , Flavonas/análise , Ginsenosídeos/análise , Glicosídeos/análise , Hidroxibenzoatos/análise , Plantas Medicinais/química , Controle de Qualidade , Espectrometria de Massas por Ionização por Electrospray , Esteroides/análise , Espectrometria de Massas em TandemRESUMO
Two novel 18, 19-secoursane triterpenoids, kakisaponin B (1) and kakisaponin C (2), an ursane type 28-nortriterpene, kakidiol (3) and one known triterpenoid rosamultin (4), were isolated from the leaves of Diospyros kaki. The structures of compounds 1 and 2 were determined as 28-O-beta-D-glucopyranosyl-3alpha,19,24-trihydoxy-18,19-secours-11,13(18)-dien-28-oic acid (1) and 28-O-beta-D-glucopyranosyl-2alpha,3alpha,19-trihydoxy-18,19-secours-11,13(18)-dien-28-oic acid (2) by chemical methods and spectra experiments. Kakidiol (3) was characterized as a C(29)-triterpene with an aromatic E-ring in structure. This is the first report of 18,19-secoursane triterpenoids and 28-nortriterpene from family Ebenaceae.
Assuntos
Diospyros/química , Extratos Vegetais/química , Folhas de Planta/química , Triterpenos/química , Espectroscopia de Ressonância Magnética , Medicina Tradicional Chinesa , Estrutura Molecular , Triterpenos/isolamento & purificaçãoRESUMO
Ginsenoside Rb1 is a representative component of panaxadiol saponins, which belongs to dammarane-type tritepenoid saponins and mainly exists in family araliaceae. It has been reported that ginsenoside Rb1 has diverse biological activities. In this paper, the research development in recent decade on its pharmacological effects of cardiovascular system, anti-senility, reversing multidrug resistance of tumor cells, adjuvant anti-cancer chemotherapy, promoting peripheral nerve regeneration, et al, are reviewed.
