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1.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 34(6): 654-658, 2023 Jan 05.
Artigo em Chinês | MEDLINE | ID: mdl-36642909

RESUMO

As a global zoonotic disease, fascioliasis is a serious threat to human and animal health and animal husbandry development. The complexity of the classification and identification of Lymnaeidae, the intermediate host of Fasciola, notably the emergence of its sibling species, leads to misunderstanding of geographical distribution and transmission potential of Fasciola. This review introduces the classification of flukes of the family Fasciolidae, describes the geographical distribution of F. hepatica and F. gigantic, and discusses the co-evolution of Fasciola and Lymnaeidae host snails, and the effects of human activities and ruminant migration on global spread and transmission of Fasciola. In addition, we revisit the intermediate host snails of Fasciola in Africa based on the latest molecular biological evidence.


Assuntos
Fasciola hepatica , Fasciola , Fasciolíase , Animais , Humanos , Fasciolíase/epidemiologia , Fasciolíase/veterinária , Caramujos , África/epidemiologia
2.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 34(4): 420-428, 2022 Aug 18.
Artigo em Chinês | MEDLINE | ID: mdl-36116936

RESUMO

Biological category is effective to indicate the evolution of organism populations between past and present. Conventional taxonomy of human parasites mainly depends on important morphological features, which suffers from a problem of categorizing related-genera species with similar morphological characteristics. With recent advances in molecular biological technologies, the effective applications of mitochondrial and ribosomal biomarkers and sequencing greatly improve the development of the taxonomic rank of human parasites. Worldwide, the classification of human parasites have been continuously revised and improved. Hereby, we re-categorize parasitic Protozoa, Trematoda, Cestoda and Nematoda, so as to provide insights into the researches on molecular systematics and genetic evolution of human parasites.


Assuntos
Nematoides , Parasitos , Trematódeos , Animais , Evolução Molecular , Humanos , Parasitos/genética , Trematódeos/genética
3.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 34(3): 300-306, 2022 Jun 23.
Artigo em Chinês | MEDLINE | ID: mdl-35896494

RESUMO

OBJECTIVE: To evaluate the diagnostic efficacy of indirect haemagglutination assay (IHA) for detection of Schistosoma japonicum infections among boatmen and fishermen in Dongting Lake region, so as to provide insights into improving the schistosomiasis surveillance program among boatmen and fishermen. METHODS: The boatmen and fishermen were detected for S. japonicum infections using IHA and Kato-Katz technique or miracidium hatching test nylon gauze simultaneously at schistosomiasis testing sites in the anchor sites for boatmen and fishermen in the Dongting Lake region during the period from 2014 to 2016, and using IHA for serological screening followed by parasitological testing of seropositives during the period from 2017 to 2019. The sensitivity and specificity of IHA were evaluated for detection of S. japonicum infections among boatmen and fishermen, with the 2014-2016 parasitological testing results as a gold standard. In addition, the seroprevalence of S. japonicum infections was compared among boatmen and fishermen with different characteristics and among years. RESULTS: A total of 306 schistosomiasis testing sites were assigned for boatmen and fishermen, and a total of 143 360 person-time boatmen and fishermen were tested for S. japonicum infections in the Dongting Lake region from 2014 to 2019. The sensitivity and specificity of IHA were 69.9%, 97.3% and 96.1% (χ2 = 74.6, P < 0.05), and 70.9%, 74.5% and 71.9% for detection of S. japonicum infections from 2014 to 2016 (χ2 = 29.4, P < 0.05), respectively. The seroprevalence of S. japonicum infections reduced from 30.3% in 2014 to 1.8% in 2019 among boatmen and fishermen, appearing an overall tendency towards a decline (Z = 1 552.4, P < 0.05). In addition, male, individuals at ages of 45 to 60 years, full-time boatmen and fishermen were more likely to be seropositive for S. japonicum infections (all P values < 0.05). CONCLUSIONS: The seroprevalence of S. japonicum infections appeared a tendency towards a decline among boatmen and fishermen in the Dongting Lake region year by year from 2014 to 2019. IHA presented a high efficacy for screening of S. japonicum infections among boatmen and fishermen in the Dongting Lake region.


Assuntos
Schistosoma japonicum , Esquistossomose Japônica , Esquistossomose , Animais , China/epidemiologia , Hemaglutinação , Humanos , Lagos , Masculino , Pessoa de Meia-Idade , Prevalência , Esquistossomose/diagnóstico , Esquistossomose/epidemiologia , Esquistossomose Japônica/diagnóstico , Esquistossomose Japônica/epidemiologia , Esquistossomose Japônica/prevenção & controle , Estudos Soroepidemiológicos
4.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 33(3): 311-316, 2021 Apr 14.
Artigo em Chinês | MEDLINE | ID: mdl-34286537

RESUMO

Due to the relative shortage of health resources, rational allocation and utilization of health resources is critical to achieving the maximum economic benefits in developing countries, which requires a health economic assessment to meet the needs to balance the competitive requirements of cost reduction and effectiveness enhancement. This review describes the advances in applications of health economic assessment techniques in four major infectious diseases, including AIDS, tuberculosis, hepatitis B and schistosomiasis. Currently, there is no standard economic assessment in the prevention and control of infectious diseases, and notably, the transparency of cost research is limited, which may affect the popularization of the study conclusions. Further health economic assessments of infectious diseases are required to improve the quality, standard and transparency of the economic evaluation through formulating strategies, to improve the standardization of studies, to improve the popularization of the study conclusions and to improve the applicability of the economic evaluation for policies.


Assuntos
Doenças Transmissíveis , Esquistossomose , Doenças Transmissíveis/epidemiologia , Análise Custo-Benefício , Humanos , Esquistossomose/prevenção & controle
5.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 33(2): 138-147, 2021 Apr 20.
Artigo em Chinês | MEDLINE | ID: mdl-34008360

RESUMO

OBJECTIVE: To evaluate the conversion of serum antibodies against Schistosoma japonicum in humans and livestock detected by immunological tests following treatment with praziquantel. METHODS: The studies pertaining to serological tests of schistosomiasis japonica published from 1991 to 2020 were retrieved in electronic databases, including Chinese National Knowledge Infrastructure, WanFang Data, PubMed and ScienceDirect. Data were extracted from included studies. The publication bias was assessed with funnel plots using the software RevMan version 5.3, and the conversion of antibodies against S. japonicum was evaluated through meta-analysis. RESULTS: A total of 40 publications were included in the final meta-analysis, consisting of 33 Chinese publications and 7 English publications, and all immunological tests were performed with indirect hemagglutination test (IHA) and enzyme-linked immunosorbent assay (ELISA). Pooled analysis showed that the negative rates of serum anti-S. japonicum antibody were 45.36% [95% confidential interval (CI): (43.96%, 46.76%)] and 20.83% [95% CI: (19.69%, 21.97%)] detected by ELISA and IHA within 6 months post praziquantel treatment, 62.95% [95% CI: (61.59%, 64.31%)] and 55.61% [95% CI: (54.21%, 57.01%)] within 6 to 12 months after treatment and 85.92% [95% CI: (84.94%, 86.90%)] and 86.90% [95% CI: (85.95%, 87.85%)] over 12 months after treatment, respectively. CONCLUSIONS: The negative rate of the serum anti-S. japonicum antibody by IHA and ELISA increased with the time of post-treatment with praziquantel. The overall negative rates of anti-S. japonicum antibody detected by IHA and ELISA are low within 12 months post praziquantel treatment. However, a high negative rate of anti-S. japonicum antibody is detected if there is no new contact with infested water after 12 months of praziquantel treatment.


Assuntos
Schistosoma japonicum , Esquistossomose Japônica , Animais , Ensaio de Imunoadsorção Enzimática , Testes de Hemaglutinação , Humanos , Praziquantel/uso terapêutico , Esquistossomose Japônica/tratamento farmacológico
6.
Adv Parasitol ; 92: 341-83, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27137452

RESUMO

Schistosomiasis remains a public health problem in many developing countries around the world. After the founding of The People's Republic of China, from 1949 till date, all levels of government, from central to local, have been attaching great importance to schistosomiasis control in The People's Republic of China. With considerable policy support and resources mobilization, the national schistosomiasis control programmes have been implemented during the past 65years. Here, we summarize the successful experience of schistosomiasis control during the process. Recommendations for the future management of the Chinese national schistosomiasis elimination programme are put forward after considering the remaining challenges, shortcomings and lessons learnt from 65years of schistosomiasis control drives in The People's Republic of China. They will help to sustain past achievements, foster the attainment of the ultimate goal of schistosomiasis elimination for the country and provide reference for schistosomiasis control programme in other countries.


Assuntos
Saúde Pública/legislação & jurisprudência , Schistosoma/fisiologia , Esquistossomose/prevenção & controle , Animais , China/epidemiologia , Erradicação de Doenças , Humanos , Esquistossomose/epidemiologia , Esquistossomose/parasitologia
7.
Nutrition ; 13(7-8): 652-5, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9263258

RESUMO

Exogenous epidermal growth factor (EGF) markedly increases the in vivo uptake of glutamine by small intestine during total parenteral nutrition (TPN). Since glutamine is the major oxidative fuel for the small intestine and is synthesized mainly in skeletal muscle, we investigated whether EGF would induce changes in the activity of the enzymes that mediate glutamine degradation (glutaminase) and synthesis (glutamine synthetase) in the two tissues. Male Sprague Dawley rats were randomized into three groups: group I (chow) were fed rat chow and water and libitum, group II (TPN) received a standard formula of TPN, and group III (TPN-EGF) received the same TPN as group II and injections of EGF (0.1 microgram/ gm body weight (bw)) subcutaneously twice daily. TPN was given for 2 wk; when EGF was administered along with TPN, the glutaminase activity of intestinal mucosa and the glutamine synthetase activity of skeletal muscle were increased, respectively, by 25% and 24% (P < 0.05, versus TPN group). These data suggest a mechanism whereby EGF enhances the intestinal utilization of glutamine by changing the activities of glutamine metabolic enzymes in the small intestine and skeletal muscle during TPN.


Assuntos
Fator de Crescimento Epidérmico/farmacologia , Glutamato-Amônia Ligase/metabolismo , Glutaminase/metabolismo , Intestino Delgado/enzimologia , Músculo Esquelético/enzimologia , Nutrição Parenteral Total/métodos , Animais , Peso Corporal , Estudos de Coortes , Inibidores Enzimáticos/metabolismo , Fator de Crescimento Epidérmico/administração & dosagem , Glutamato-Amônia Ligase/efeitos dos fármacos , Glutamatos/metabolismo , Glutaminase/efeitos dos fármacos , Glutamina/efeitos dos fármacos , Glutamina/metabolismo , Ácidos Hidroxâmicos/metabolismo , Intestino Delgado/efeitos dos fármacos , Intestino Delgado/metabolismo , Masculino , Mucosa/efeitos dos fármacos , Mucosa/enzimologia , Mucosa/metabolismo , Músculo Esquelético/efeitos dos fármacos , Músculo Esquelético/metabolismo , NAD/metabolismo , Ratos , Ratos Sprague-Dawley
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