[Efficacy and tolerability of dapoxetine in the treatment of premature ejaculation].

OBJECTIVE: To investigate the efficacy and adverse effects of dapoxetine in the treatment of premature ejaculation. METHODS: We randomly assigned outpatients with premature ejaculation in the proportion of 2:1 to receive 30 mg dapoxetine on demand (n =78) or 50 mg sertraline qd for one month (n = 39). Follow-up was accomplished in 95 cases, 63 in the dapoxetine group and 32 in the sertraline group. We recorded the intravaginal ejaculatory latency time (IELT), clinical global impression of change (CGIC) score, and adverse reactions of the patients and compared them between the two groups. RESULTS: IELT was significantly increased in both the dapoxetine (from [0.87 ± 0.31] to [2.84 ± 0.68] min, P < 0.05) and the sertraline group (from [0.84 ± 0.28] to [2.71 ± 0.92] min, P < 0.05) after medication. Based on the CGIC scores in premature ejaculation, the rate of excellence or effectiveness was 36.5% in the dapoxetine and 37. 5% in the sertraline group, and the rate of improvement was 63.5% in the former and 71.9% in the latter. The incidence rates of dizziness, nausea, headache, and diarrhea were slightly higher (P > 0.05) while those of fatigue, somnolence, and dry mouth significantly higher (P < 0.05) in the sertraline than in the dapoxetine group. CONCLUSION: On-demand oral medication of dapoxetine is effective and well-tolerated for the treatment of premature ejaculation.

[Expression of IGF-IR and COX-2 in renal cell carcinoma and their relationship with cell proliferation].

AIM: To investigate the expression of IGF-IR and COX-2 in renal cell carcinoma(RCC). To explore the correlation among IGF-IR, COX-2 and PCNA expression. METHODS: Immunohistochemical staining was performed to detect the expression of IGF-IR, COX-2 and PCNA in 64 cases of RCC. RESULTS: The positive rates of IGF-IR expression and COX-2 expression were 60.9%(39/64) and 51.6%(33/64) in RCC respectively. The expressions of IGF-IR and COX-2 in RCC tissues were not related to the histological type of RCC (P>0.05), but they were related to and increased with the size and clinical stages of RCC (P<0.05). The expression of IGF-IR was related to pathological grades, but COX-2 was not. The expression of IGF-IR was positively related with the expression of COX-2 and PCNA respectively, but there was negative correlation between COX-2 and PCNA. CONCLUSION: The experiment suggests that IGF-IR and COX-2 may produce a synergetic effect in oncogenesis and progression of RCC. Detection of these genes has positive effects on early diagnosis, malignancy determination, prognosis and treatment of RCC.