1.
Prenat Diagn
; 33(2): 198-200, 2013 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23192749
Assuntos
Transtornos Cromossômicos/diagnóstico , Síndrome de Down/diagnóstico , Trissomia/diagnóstico , Dissomia Uniparental/diagnóstico , Adulto , Aneuploidia , Cromossomos Humanos Par 22 , Reações Falso-Positivas , Feminino , Humanos , Testes para Triagem do Soro Materno , Mosaicismo , Gravidez , Análise de Sequência de DNA
2.
Int J Clin Pharmacol Ther Toxicol
; 26(3): 118-21, 1988 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2457561
RESUMO
This study investigated the influence of single dose of 200 mg and 400 mg cimetidine on the pharmacokinetics of procainamide (PA) in healthy Chinese. The results show that AUC of PA was significantly raised by 38% and 24% with a significant reduction in renal clearance by 40% and 31%, respectively, when single dose of 400 mg or 200 mg cimetidine was coadministered. Significant changes of AUC and renal clearance of the active metabolite--N-acetylprocainamide (NAPA) were found only following the dose of 400 mg cimetidine. The larger dose of cimetidine produced greater alteration in the PA and NAPA pharmacokinetics. The interaction is mainly associated with their reduced renal clearance.
Assuntos
Cimetidina/farmacologia , Procainamida/farmacocinética , Acecainida/sangue , Adulto , Relação Dose-Resposta a Droga , Interações Medicamentosas , Humanos , Masculino
3.
Shi Yan Sheng Wu Xue Bao
; 20(2): 225-35, 1987 Jun.
Artigo
em Chinês
| MEDLINE
| ID: mdl-3116794
