Analysis of clinical application effects and challenges of early warning system for the high-risk obstetric women of China: A scoping review.

BACKGROUND: Obstetric critical illness is an important factor that leads to an increase in maternal mortality. Early warning assessment can effectively reduce maternal and neonatal mortality and morbidity. However, there are multiple early warning systems, and the effect and applicability of each system in China still need to be explored. OBJECTIVES: To elaborate on the application, effectiveness and challenges of the existing early warning systems for high-risk obstetric women in China and to provide a reference for clinical practice. DESIGN: A scoping review guided by the Arksey and O'Malley framework and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for scoping review (PRISMA-ScR) guidelines. ELIGIBILITY CRITERIA: We included original studies related to early warning and excluded those that were guidelines, consensus and reviews. The included studies were published in Chinese or English by Chinese scholars as of June 2021. DATA SOURCES: CNKI, Wanfang, VIP, Cochrane, CINAHL, Embase, PubMed and Web of Science databases were searched systematically, and the reference sections of the included papers were snowballed. RESULTS: In total, 598 articles were identified. These articles were further refined using keyword searches and exclusion criteria, and 17 articles met the inclusion criteria. We extracted data related to each study's population, methods and results. Early warning tools, outcome indices, effects and challenges are discussed. CONCLUSIONS: Although all studies have shown that early warning systems have good application effects, the use of early warning systems in China is still limited, with poor regional management and poor sensitivity for specific obstetric women. Future research needs to develop more targeted early warning tools for high-risk obstetric women and address the current challenges in clinical applications.

Career adaptability of newly graduated nurses at an obstetrics and gynaecology hospital in China: A qualitative study.

AIM: The aim of this study was to gain insight into factors affecting career adaptability of newly graduated nurses and ways to improve them. BACKGROUND: Newly graduated nurses face an important transition from student to professional. Unfortunately, the nurse turnover rate is high due to maladaptation. Factors influencing career adaptability and improvement methods have not been clearly addressed. METHODS: Using a descriptive qualitative study with thematic analysis, 15 newly graduated nurses from a tertiary obstetrics and gynaecology teaching hospital in China were interviewed. RESULTS: Six themes affecting career adaptability were found: personality, self-confidence, occupational care focus, work-related stress, basic professional competency and gap between reality and expectations. Four themes improving career adaptability were identified: strong social support, self-adjustment, self-development and career preparation. Eight subthemes were also identified. CONCLUSIONS: Individual, family and work factors were among those affecting career adaptability among newly graduated nurses. Newly graduated nurses would improve their career adaptability through self-adjustment and social support. Helping them to promote these factors and measures is conducive to improving their career adaptability and reducing staff turnover. IMPLICATIONS FOR NURSING MANAGEMENT: Nurse managers should be aware of the key factors affecting career adaptability among newly graduated nurses and design targeted improvement programmes.

Spectrum of ß-Thalassemia Mutations in Some Areas of Guangxi Zhuang Autonomous Region of Southern China: A Study on a Pediatric Population Aged 0-15 Years.

ß-Thalassemia (ß-thal), one of the most common form of single-gene inheritable blood diseases in the world, is highly prevalent in southern China, especially in the Guangxi Zhuang Autonomous Region. To update the ß-thal mutation spectrum in this region, we performed hematological and genetic analyses on 888 ß-thal major (ß-TM), ß-thal intermedia (ß-TI) and ß-thal carrier patients, aged 0-15 years old, from different parts of Guangxi Province. We identified 55 genotypes and 18 ß-thal mutations. The codons 41/42 (-TTCT) (HBB: c.126_129delCTTT) (43.97%), codon 17 (A>T) (HBB: c.52A>T) (25.43%), -28(A>G) (HBB: c.-78A>G) (8.18%), IVS-II-654 (C>T) (HBB: c.316-197C>T) (7.85%) and codon 26 (G>A) (HBB: c.79G>A) (5.02%) were the five most common, accounting for more than 90.0%. The results of our study are providing an up-to-date ß-thal mutation spectrum in the 0-15-year-old pediatric population, which will help genetic counseling and prevention of ß-TM in mainland China's most endemic region, Guangxi Zhuang Autonomous Region.

Use of in-bed cycling combined with passive joint activity in acute respiratory failure patients receiving mechanical ventilation.

BACKGROUND: This study aimed to investigate the use of in-bed cycling combined with passive joint movement of upper limbs in patients with acute respiratory failure (ARF) in Department of Intensive Care Unit (ICU). METHODS: One hundred and seven patients receiving mechanical ventilation (MV) for ARF were randomly divided into the intervention group and the control group. Patients in the control group received routine intensive care. In the intervention group, the lower extremity in-bed cycling was combined with the upper extremity passive joint activities. RESULTS: The time of MV, ICU stay, and incidence of ICU-acquired weakness (ICU-AW) were significantly lower, but the Barthel index score was markedly higher in the intervention group than in the control group (P<0.05). CONCLUSIONS: The in-bed cycling combined with passive joint movement of upper limbs is safe and feasible in patients with ARF. It can reduce the duration of MV, ICU stay and incidence of ICU-AW as well as improve their ability to live independently.

The complete mitochondrial genome sequence of Cynoglossus sinicus (Pleuronectiformes: Cynoglossidae).

Cynoglossidae (tongue soles) mitogenomes have been found to be translocated in their control region and a tRNA gene inversed, but no gene rearrangement in Soleidae, the closest family to Cynoglossidae, has been detected. In order to explore whether or not mitogenomes of tongue soles bear other gene-rearrangement types, we determined another tongue sole mitogenome of Cynoglossus sinicus. The total length of this mitogenome is 16,478 bp, and the tRNA-Gln gene is translocated from the light strand (L-strand) to the heavy strand (H-strand), accompanied by shuffling of tRNA-Gln, Ile and Met genes with a 143 bp intergenic spacer between tRNA-Gln and Ile. The control region (CR) might translocate to the position between the ND1 and the tRNA-Gln genes. The order of the rest genes is identical to that of the typical fish.

The complete mitochondrial genome sequence of Heteromycteris japonicus (Pleuronectiformes: Soleidae).

The bamboo sole Heteromycteris japonicus (Pleuronectiformes: Soleidae) is characterized by both eyes on the right side of the body and a rostral hook. In this article, the complete mitochondrial genome sequence of this sole was first determined. The total length is 17,111 bp, including 13 protein-coding genes, 22 tRNA genes and 2 rRNA genes (12 S and 16 S), as well as a putative control region and a putative L-strand replication origin (OL). Gene contents, locations and arrangements are identical to those of typical bony fishes. Overall base composition of the mitogenome is 29.2%, 27.5%, 16.3% and 27.1% for A, C, G and T, with a high A + T content (56.3%). The determination of H. japonicus mitogenome sequence could contribute to understanding the systematic evolution of the genus Heteromycteris and further phylogenetic study on Soleidae and Pleuronectiformes.

The complete mitochondrial genome of a striped sole Zebrias zebrinus (Pleuronectiformes: Soleidae).

Zebrias zebrinus belongs in the family Soleidae of Pleuronectiformes. There are overlaps in the ranges of identification characters between Z. zebrinus and another striped sole Z. fasciatus. In this study, the complete mitochondrial genome of Z. zebrinus was first determined. The total length was 16,758 bp, including 13 protein-coding genes, 22 tRNA genes, and 2 rRNA genes (12S and 16S), as well as a putative control region and a putative L-strand replication origin (O(L)). Gene contents, locations, and arrangements were identical to those of typical bony fishes. The overall base composition of the mitogenome was 28.7%, 30.0%, 15.2%, and 26.1% for A, C, G, and T, respectively, with an A + T content of 54.8%. This result would expect the contribution to the molecular identification of this species and further phylogenetic study of Soleidae and Pleuronectiformes.